Featured Research

from universities, journals, and other organizations

Mosquito genetic complexity may take a bite out of efforts to control malaria

Date:
April 1, 2013
Source:
Genetics Society of America
Summary:
New research documents how the genetic structure of African malaria mosquitoes is evolving, which could lead to implications for controlling malaria.

A surprising research discovery in mosquitoes could affect future prospects for malaria control. A team of scientists from West Africa, the United States and the United Kingdom found that the mosquito, Anopheles gambiae, which was thought to be splitting into two completely new species, may actually have a more complex range of forms due to frequent inter-mating. The resulting hybrids may have implications for insecticide resistance and malaria parasite infectivity.

The study published in the April 2013 issue of the journal Genetics, documents substantial amounts of hybridization among two separate mosquito types in a large area spanning four countries in sub-Saharan western Africa.

"Our research shows that Anopheles gambiae mosquitoes, which are responsible for most cases of malaria in Africa, are more genetically complex than we thought due to interbreeding," said David J. Conway, Ph.D., one of the researchers from the London School of Hygiene & Tropical Medicine in the United Kingdom, and the Medical Research Council Unit in The Gambia. "Mosquitoes are very good at evolving quickly and this information will help us use existing control methods appropriately and consider possible new tools that will further malaria control efforts in Africa."

The scientists collected mosquitoes from houses located within 100 kilometers of the Atlantic coast in Senegal, Gambia, Guinea Bissau, and Republic of Guinea. They characterized the mosquitoes' DNA to identify the proportions of each major type, "M," "S," and hybrid "M/S" forms. Pools of each of the forms of mosquitoes from representative sites were analyzed for genome-wide genetic profiles revealing that the genomes, which are known to be different between the forms, are not different in these areas. That is, the genetic variation that exists is shared between the forms, as if they were a single species.

"Mosquito-borne illnesses can be a death sentence in developing nations," said Mark Johnston, Editor-in-Chief of the journal Genetics. "It is crucial that we understand the genetic architecture of mosquito populations so we can develop ways to safeguard people from malaria. This research reveals some of the difficulty of eradicating this disease."

The genome-wide SNP array was supported by joint funding from several sources including Burroughs Wellcome Fund Request 1008238, the Broad Institute Director's Fund, Harvard School of Public Health Department of Immunology and Infectious Diseases under direction of D.F. Wirth, Wellcome Trust Programme Grant 077229/Z/05/Z to F.C. Kafatos and G.K. Christophides, and the DeLuca Professorship from Boston College to MATM. This work was enabled by funding from the UK Medical Research Council (MRC) and FNIH/Gates Grand Challenges in Global Health to the MRC Unit in The Gambia.


Story Source:

The above story is based on materials provided by Genetics Society of America. Note: Materials may be edited for content and length.


Journal Reference:

  1. D. C. Nwakanma, D. E. Neafsey, M. Jawara, M. Adiamoh, E. Lund, A. Rodrigues, K. M. Loua, L. Konate, N. Sy, I. Dia, T. S. Awolola, M. A. T. Muskavitch, D. J. Conway. Breakdown in the Process of Incipient Speciation in Anopheles gambiae. Genetics, 2013; DOI: 10.1534/genetics.112.148718

Cite This Page:

Genetics Society of America. "Mosquito genetic complexity may take a bite out of efforts to control malaria." ScienceDaily. ScienceDaily, 1 April 2013. <www.sciencedaily.com/releases/2013/04/130401100704.htm>.
Genetics Society of America. (2013, April 1). Mosquito genetic complexity may take a bite out of efforts to control malaria. ScienceDaily. Retrieved August 27, 2014 from www.sciencedaily.com/releases/2013/04/130401100704.htm
Genetics Society of America. "Mosquito genetic complexity may take a bite out of efforts to control malaria." ScienceDaily. www.sciencedaily.com/releases/2013/04/130401100704.htm (accessed August 27, 2014).

Share This




More Health & Medicine News

Wednesday, August 27, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

WHO Calls for Ban on E-Cigarette Sales to Minors

WHO Calls for Ban on E-Cigarette Sales to Minors

AFP (Aug. 26, 2014) The World Health Organization called Tuesday on governments should ban the sale of e-cigarettes to minors, warning that they pose a "serious threat" to foetuses and young people. Duration: 01:44 Video provided by AFP
Powered by NewsLook.com
Have You Ever Been 'Sleep Drunk?' 1 in 7 Has

Have You Ever Been 'Sleep Drunk?' 1 in 7 Has

Newsy (Aug. 26, 2014) A study published in the journal "Neurology" interviewed more than 19,000 people and found 15 percent suffer from being "sleep drunk." Video provided by Newsy
Powered by NewsLook.com
Does Medical Marijuana Reduce Painkiller Overdose Deaths?

Does Medical Marijuana Reduce Painkiller Overdose Deaths?

Newsy (Aug. 26, 2014) A new study found fewer deaths from prescription drug overdoses in states that have legalized medical marijuana. But experts disagree on the results. Video provided by Newsy
Powered by NewsLook.com
Official: British Ebola Sufferer Receiving Experimental Drug

Official: British Ebola Sufferer Receiving Experimental Drug

AFP (Aug. 26, 2014) A British nurse infected with Ebola while working in Sierra Leone is being given the same experimental drug used on two US missionaries who have recovered for the disease, doctors in London say. Duration: 00:44 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

    Technology News



    Save/Print:
    Share:

    Free Subscriptions


    Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

    Get Social & Mobile


    Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

    Have Feedback?


    Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
    Mobile: iPhone Android Web
    Follow: Facebook Twitter Google+
    Subscribe: RSS Feeds Email Newsletters
    Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins