Featured Research

from universities, journals, and other organizations

Women with HIV shown to have elevated resting energy expenditure

Date:
April 16, 2013
Source:
Elsevier
Summary:
Studies have shown that about 10 percent of men infected with human immunodeficiency virus (HIV) have an elevated resting energy expenditure (REE). Their bodies use more kilocalories for basic functions including circulation, body temperature, and breathing. Most studies have been conducted in men and those with solely women have had small sample sizes.

Studies have shown that about 10 percent of men infected with human immunodeficiency virus (HIV) have an elevated resting energy expenditure (REE). Their bodies use more kilocalories for basic functions including circulation, body temperature, and breathing. Most studies have been conducted in men and those with solely women have had small sample sizes. A team of researchers has sought to rectify this with a matched, prospective, cross-sectional study. The results are featured in a new report published by the Journal of the Academy of Nutrition and Dietetics.

Related Articles


"To our knowledge, no studies have been conducted that dissect the effect of HIV infection versus antiretroviral therapy," says lead investigator Grace McComsey, MD, FIDSA, Chief Pediatric Infectious Diseases, Rheumatology and Global Health at Case Western Reserve University School of Medicine. "The purpose of our study was to compare REE in HIV-infected women who have never been on antiretroviral therapy (ART), those on ART with virologic suppression, those on ART with detectable HIV-1 RNA, and HIV-negative, healthy women." Antiretroviral therapy typically consists of at least three drugs to fight against fatal HIV effects and improve quality of life.

The study team recruited women from the John T. Carey Special Immunology Unit at University Hospitals Case Medical Center, an out-patient HIV clinic in Cleveland, Ohio between 2004 and 2011. The women were matched by age and body mass index (BMI). Healthy women who volunteered to participate in the control group were mostly hospital employees. In total, 87 women participated, 62 with HIV and 25 without.

All participants received a clinical evaluation for weight, height, and waist and hip measurements and responded to questions about their exercise habits and alcohol, tobacco, and drug use. Investigators determined their body composition and measured their oxygen consumption to determine REE. They also consulted medical records for further information about current medications and HIV diagnosis details.

The study produced the following significant findings:

· REE is significantly higher in HIV-infected women who have never been on ART when compared to healthy women.

· REE is significantly higher, when adjusted for body composition changes, in HIV-infected women who are on ART with undetectable HIV-1 RNA compared to healthy controls.

· REE is significantly higher in HIV-infected women on ART with detectable HIV-1 RNA compared to controls.

· REE was not different between the HIV-infected groups.

In addition analysis revealed that REE strongly correlates with two common equations used to predict energy expenditure and with body cell mass, BMI, and fat mass.

The investigators hypothesized that those with increased REE may have a greater absolute production of reactive oxygen species if tissue oxygen concentration also increases, leading to more oxidative stress. This needs to be investigated in future studies.

"We showed that REE is elevated in ART-naοve HIV-infected women and continues to be elevated when on effective ART, regardless of virologic suppression, when compared to age and BMI matched healthy women," says Dr. McComsey. "This suggests an effect of HIV infection itself and not antiretroviral therapy on REE. The exact mechanism by which this occurs is unknown, but could be due to heightened inflammation or immune activation, which occurs in HIV infection."

Dr. McComsey also notes the need for further study of ART initiation to assess the effect of HIV infection on REE and the effect of specific antiretrovirals on REE.


Story Source:

The above story is based on materials provided by Elsevier. Note: Materials may be edited for content and length.


Journal Reference:

  1. Alison L Mittelsteadt et al. The Effects of Human Immunodeficiency Virus and Antiretroviral Therapy on Resting Energy Expenditure in Adult HIV-Infected Women: A Matched, Prospective, Cross-Sectional Study. Journal of the Academy of Nutrition and Dietetics, 2013 DOI: 10.1016/j.jand.2013.02.005

Cite This Page:

Elsevier. "Women with HIV shown to have elevated resting energy expenditure." ScienceDaily. ScienceDaily, 16 April 2013. <www.sciencedaily.com/releases/2013/04/130416085312.htm>.
Elsevier. (2013, April 16). Women with HIV shown to have elevated resting energy expenditure. ScienceDaily. Retrieved December 22, 2014 from www.sciencedaily.com/releases/2013/04/130416085312.htm
Elsevier. "Women with HIV shown to have elevated resting energy expenditure." ScienceDaily. www.sciencedaily.com/releases/2013/04/130416085312.htm (accessed December 22, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, December 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Touch-Free Smart Phone Empowers Mobility-Impaired

Touch-Free Smart Phone Empowers Mobility-Impaired

Reuters - Innovations Video Online (Dec. 21, 2014) — A touch-free phone developed in Israel enables the mobility-impaired to operate smart phones with just a movement of the head. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Earthworms Provide Cancer-Fighting Bacteria

Earthworms Provide Cancer-Fighting Bacteria

Reuters - Innovations Video Online (Dec. 21, 2014) — Polish scientists isolate bacteria from earthworm intestines which they say may be used in antibiotics and cancer treatments. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Existing Chemical Compounds Could Revive Failing Antibiotics, Says Danish Scientist

Existing Chemical Compounds Could Revive Failing Antibiotics, Says Danish Scientist

Reuters - Innovations Video Online (Dec. 21, 2014) — A team of scientists led by Danish chemist Jorn Christensen says they have isolated two chemical compounds within an existing antipsychotic medication that could be used to help a range of failing antibiotics work against killer bacterial infections, such as Tuberculosis. Jim Drury went to meet him. Video provided by Reuters
Powered by NewsLook.com
Hugging It Out Could Help You Ward Off A Cold

Hugging It Out Could Help You Ward Off A Cold

Newsy (Dec. 21, 2014) — Carnegie Mellon researchers found frequent hugs can help people avoid stress-related illnesses. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins