Featured Research

from universities, journals, and other organizations

Development of novel therapies for endothelial damage may heal atherosclerotic plaques

Date:
April 21, 2013
Source:
Federation of American Societies for Experimental Biology
Summary:
Heart disease and approximately half of all strokes are the results of advanced atherosclerosis with damaged endothelium, the inner lining of blood vessels. In 2009, the direct and indirect annual cost of heart disease and stroke was approximately $312.6 billion. Projections are for the total cost of heart disease to increase from $523 to $1.126 billion from 2013 to 2030.

Heart disease and approximately half of all strokes are the results of advanced atherosclerosis with damaged endothelium, the inner lining of blood vessels. In 2009, the direct and indirect annual cost of heart disease and stroke was approximately $312.6 billion. Projections are for the total cost of heart disease to increase from $523 to $1.126 billion from 2013 to 2030. And by 2030, it is expected that there will be more than 148 million of the US population would have heart disease. Development of new technologies for assessing and treating endothelium damage will help reduce that financial burden as reduce the human health burden resulting from atherosclerosis.

Related Articles


Dr. Hua Pan, Research Instructor in Medicine at Dr. Samuel Wickline's Laboratory in Washington University School of Medicine, investigated quantitative evaluation and developed novel therapies for endothelial barrier damage. The evolution and severity of endothelium damage in advanced atherosclerotic plaque remain unknown, in part because quantifiable methods are lacking for its in vivo assessment. Her latest study is the first to demonstrate, in a well-established atherosclerosis mouse model, ApoE deficient mice, a multifunctional perfluorocarbon (PFC) nanoparticle (NP) for quantification of endothelial damage as well as targeted anti-inflammatory drug delivery to the endothelium damage site.

The study, conducted in ApoE deficient mice, quantified endothelium damage by using PFC NP retained in mouse aorta as surrogate. It demonstrated the evolution and severity of endothelium damage in correlation to the length of the animal fat-diet consumption. Moreover, the same PFC NP loaded with anti-inflammatory drug, NF-κB inhibitor, down-regulated inflammation. Dr. Wickline noted, this finding provided a new avenue for defining disease stage and for following therapy to heal dangerous atherosclerotic plaques.

Her findings will be presented April 22, 2013 during Experimental Biology 2013 in Boston, MA.


Story Source:

The above story is based on materials provided by Federation of American Societies for Experimental Biology. Note: Materials may be edited for content and length.


Cite This Page:

Federation of American Societies for Experimental Biology. "Development of novel therapies for endothelial damage may heal atherosclerotic plaques." ScienceDaily. ScienceDaily, 21 April 2013. <www.sciencedaily.com/releases/2013/04/130421153833.htm>.
Federation of American Societies for Experimental Biology. (2013, April 21). Development of novel therapies for endothelial damage may heal atherosclerotic plaques. ScienceDaily. Retrieved December 18, 2014 from www.sciencedaily.com/releases/2013/04/130421153833.htm
Federation of American Societies for Experimental Biology. "Development of novel therapies for endothelial damage may heal atherosclerotic plaques." ScienceDaily. www.sciencedaily.com/releases/2013/04/130421153833.htm (accessed December 18, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Thursday, December 18, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Kids Die While Under Protective Services

Kids Die While Under Protective Services

AP (Dec. 18, 2014) As part of a six-month investigation of child maltreatment deaths, the AP found that hundreds of deaths from horrific abuse and neglect could have been prevented. AP's Haven Daley reports. (Dec. 18) Video provided by AP
Powered by NewsLook.com
UN: Up to One Million Facing Hunger in Ebola-Hit Countries

UN: Up to One Million Facing Hunger in Ebola-Hit Countries

AFP (Dec. 17, 2014) Border closures, quarantines and crop losses in West African nations battling the Ebola virus could lead to as many as one million people going hungry, UN food agencies said on Wednesday. Duration: 00:52 Video provided by AFP
Powered by NewsLook.com
When You Lose Weight, This Is Where The Fat Goes

When You Lose Weight, This Is Where The Fat Goes

Newsy (Dec. 17, 2014) Can fat disappear into thin air? New research finds that during weight loss, over 80 percent of a person's fat molecules escape through the lungs. Video provided by Newsy
Powered by NewsLook.com
Why Your Boss Should Let You Sleep In

Why Your Boss Should Let You Sleep In

Newsy (Dec. 17, 2014) According to research out of the University of Pennsylvania, waking up for work is the biggest factor that causes Americans to lose sleep. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins