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Contact killing of Salmonella by human fecal bacteria

Date:
April 23, 2013
Source:
Norwich BioScience Institutes
Summary:
Researchers have recently found a novel mode of interaction between Salmonella, a foodborne pathogen, and the bacteria that live in our guts. Fecal bacteria collected from healthy donors effectively inactivated Salmonella, when they were allowed close contact. Mathematical modelling of this interaction is now being used to find new ways of controlling Salmonella.

Salmonella and faecal bacteria.
Credit: Kathryn Cross, IFR

Our gut is home to trillions of bacteria, numbering more than the cells in the rest of our body, and these bacteria help us to digest our food, absorb nutrients and strengthen our immune system. This complex bacterial ecosystem, called the gut microbiota, also helps to prevent bad bacteria from colonising our bodies and making us ill.

As part of the symbiotic relationship between the gut microbiota and our bodies, the bacteria derive nutrition from our food and convert it into compounds that we can't make ourselves. Some of these compounds are part of the arsenal that combats harmful bacteria. To date, these are the only identified defense mechanisms associated with gut bacteria.

Dr Carmen Pin, and PhD student Gaspar Avendaρo-Perez at the Institute of Food Research, which is strategically funded by the Biotechnology and Biological Sciences Research Council, have recently found a novel mode of interaction between Salmonella, a foodborne pathogen, and the gut bacteria that leads to the inactivation of Salmonella. This interaction relies on Salmonella and the gut bacteria being in close proximity, or through cell to cell contact. This new way of interaction between the "good" and the" bad" bacteria may contribute to prevent intestinal colonization and infection by foodborne pathogens.

The researchers collected faecal samples from several healthy human donors and used the experimental colon model facility of the Institute of Food Research to culture faecal bacteria together with Salmonella under conditions that mimicked those in the human colon. Gut bacteria effectively inactivated Salmonella in mixed culturesbut only when cell contact between both populations was possible. Salmonella inactivation was not observed when a membrane was included into the system to prevent cell contact between populations.


Story Source:

The above story is based on materials provided by Norwich BioScience Institutes. Note: Materials may be edited for content and length.


Journal Reference:

  1. G. Avendano-Perez, C. Pin. Loss of culturability of Salmonella Typhimurium upon cell-cell contact with human faecal bacteria. Applied and Environmental Microbiology, 2013; DOI: 10.1128/%u200BAEM.00092-13

Cite This Page:

Norwich BioScience Institutes. "Contact killing of Salmonella by human fecal bacteria." ScienceDaily. ScienceDaily, 23 April 2013. <www.sciencedaily.com/releases/2013/04/130423110817.htm>.
Norwich BioScience Institutes. (2013, April 23). Contact killing of Salmonella by human fecal bacteria. ScienceDaily. Retrieved September 22, 2014 from www.sciencedaily.com/releases/2013/04/130423110817.htm
Norwich BioScience Institutes. "Contact killing of Salmonella by human fecal bacteria." ScienceDaily. www.sciencedaily.com/releases/2013/04/130423110817.htm (accessed September 22, 2014).

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