Featured Research

from universities, journals, and other organizations

New study confirms link between weight loss and blood pressure for individuals with specific genetic polymorphisms

Date:
April 25, 2013
Source:
Robert Wood Johnson Medical School
Summary:
Your genetic makeup can help determine how well your body will respond to weight loss efforts aimed at controlling high blood pressure, a new study confirms.

Your genetic makeup can help determine how well your body will respond to weight loss efforts aimed at controlling high blood pressure, a new study confirms.

Related Articles


The multi-institutional study, led by researchers at The Cardiovascular Institute, part of the University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, may help clarify how hypertension develops and progresses in certain individuals and also identify people for whom weight loss programs are most likely to help reduce blood pressure. Results were published in the current issue of Hypertension 2013;61:857-863.

The Trial of Nonpharmacologic Interventions in the Elderly (TONE) looked at 21 polymorphisms that have been identified as relating to hypertension, obesity, and diabetes mellitus to see what impact weight loss and sodium-reduction programs would have on blood pressure. Polymorphisms are the elements of a person's DNA that make it different from another's and allow for diversity in such varied areas as eye color, hair texture, and even blood type. The TONE study identified several polymorphisms that relate to weight sensitivity with regard to hypertension, according to principal investigator John B. Kostis, MD, John G. Detwiler professor of cardiology, professor of medicine and pharmacology, associate dean for cardiovascular research, and director of The Cardiovascular Institute of Robert Wood Johnson Medical School.

The study sheds some light on an issue that has received little attention in the past, the researchers said.

"There are more than a thousand papers discussing the question of what the impact is on blood pressure of decreasing the amount of salt you consume in your diet -- what is called salt sensitivity. But, there is nobody talking about weight sensitivity, and weight loss is equally or more important in controlling blood pressure," Dr. Kostis said.

"Our work describes the variability of blood pressure drop in response to weight loss, according to a number of genetic polymorphisms," added William J. Kostis, PhD, MD, clinical and research fellow in medicine, Massachusetts General Hospital, Cardiology Division, alumnus of Robert Wood Johnson Medical School, and member of The Cardiovascular Institute, who was the first author of the study.

Participants in the TONE study -- individuals age 60 to 80 who were already taking one or two anti-hypertensive medications -- were randomly assigned to one of four interventions: • Intensive dietary intervention focused on sodium reduction • Weight loss program • Combination of weight loss and sodium-reduction programs • Attention control, in which individuals attended meetings that discussed dentistry, podiatry, or other topics unrelated to hypertension, weight loss, or sodium reduction

Regardless of the intervention, participants' levels of anti-hypertensive medication remained the same throughout, to remove medication changes as a variable.

"The study showed that both weight loss, if individuals are overweight, and decreased sodium intake may each lead to lower blood pressure, and the combination of weight loss and sodium restriction is more effective than either strategy alone," noted Dr. William Kostis.

Physicians can put these findings to use today through a blood test or even saliva test that measures genotype, Dr. John Kostis said. They can compare the patient's genetic background with the polymorphisms that have been identified in the study and counsel patients accordingly, offering advice as to which type of intervention may be more successful in lowering that patient's blood pressure, he said.

"With genomic studies becoming more widespread and less expensive, evaluating weight sensitivity may be one way to identify individuals who may benefit more from weight loss, as compared with other types of lifestyle interventions, like cutting salt from their diet," Dr. William Kostis said.

"Analysis of the polymorphisms also may give an indication of how much of a drop in blood pressure a person should expect, if he or she were to lose a given amount of weight," Dr. John Kostis added.

In addition to Dr. John Kostis and Dr. William Kostis, the research team included Nora M. Cosgrove, RN; Jerry Q. Cheng, PhD; and Yingzi Deng, MD, MS, from The Cardiovascular Institute of New Jersey, part of UMDNJ-Robert Wood Johnson Medical School. Colleagues from Rutgers, The State University of New Jersey; the Centers for Disease Control and Prevention; Tulane University School of Public Health and Tropical Medicine; Wake Forest School of Medicine; The Johns Hopkins University School of Medicine; and Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins Medical Institutions, also contributed to the study.


Story Source:

The above story is based on materials provided by Robert Wood Johnson Medical School. Note: Materials may be edited for content and length.


Cite This Page:

Robert Wood Johnson Medical School. "New study confirms link between weight loss and blood pressure for individuals with specific genetic polymorphisms." ScienceDaily. ScienceDaily, 25 April 2013. <www.sciencedaily.com/releases/2013/04/130425164407.htm>.
Robert Wood Johnson Medical School. (2013, April 25). New study confirms link between weight loss and blood pressure for individuals with specific genetic polymorphisms. ScienceDaily. Retrieved April 1, 2015 from www.sciencedaily.com/releases/2013/04/130425164407.htm
Robert Wood Johnson Medical School. "New study confirms link between weight loss and blood pressure for individuals with specific genetic polymorphisms." ScienceDaily. www.sciencedaily.com/releases/2013/04/130425164407.htm (accessed April 1, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Wednesday, April 1, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

7-Year-Old Girl Gets 3-D Printed 'robohand'

7-Year-Old Girl Gets 3-D Printed 'robohand'

AP (Mar. 31, 2015) — Although she never had much interest in prosthetic limbs before, Faith Lennox couldn&apos;t wait to slip on her new robohand. The 7-year-old, who lost part of her left arm when she was a baby, grabbed it as soon as it came off a 3-D printer. (March 31) Video provided by AP
Powered by NewsLook.com
Solitair Device Aims to Takes Guesswork out of Sun Safety

Solitair Device Aims to Takes Guesswork out of Sun Safety

Reuters - Innovations Video Online (Mar. 31, 2015) — The Solitair device aims to take the confusion out of how much sunlight we should expose our skin to. Small enough to be worn as a tie or hair clip, it monitors the user&apos;s sun exposure by taking into account their skin pigment, location and schedule. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com
Soda, Salt and Sugar: The Next Generation of Taxes

Soda, Salt and Sugar: The Next Generation of Taxes

Washington Post (Mar. 30, 2015) — Denisa Livingston, a health advocate for the Dinι Community Advocacy Alliance, and the Post&apos;s Abby Phillip discuss efforts around the country to make unhealthy food choices hurt your wallet as much as your waistline. Video provided by Washington Post
Powered by NewsLook.com
UnitedHealth Buys Catamaran

UnitedHealth Buys Catamaran

Reuters - Business Video Online (Mar. 30, 2015) — The $12.8 billion merger will combine the U.S.&apos; third and fourth largest pharmacy benefit managers. Analysts say smaller PBMs could also merge. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins