Featured Research

from universities, journals, and other organizations

Scientists find chemical that causes 'kidney' failure in mosquitoes

Date:
May 29, 2013
Source:
Ohio State University
Summary:
Scientists have discovered a chemical that causes "kidney" failure in mosquitoes, which may pave the way to the development of new insecticides to fight deadly mosquito-transmitted diseases such as malaria and dengue fever.

Scientists have discovered a chemical that causes "kidney" failure in mosquitoes.
Credit: Henrik Larsson / Fotolia

An Ohio State University researcher and his collaborators have discovered a chemical that causes "kidney" failure in mosquitoes, which may pave the way to the development of new insecticides to fight deadly mosquito-transmitted diseases such as malaria and dengue fever.

The discovery is reported in the May 29 issue of the online journal PLOS ONE .

"Our team has found a chemical that interferes with the function of a class of mosquito proteins, called potassium channels, and which compromises the ability of mosquitoes to excrete urine," said Peter Piermarini, an assistant professor of entomology based on the Wooster campus of Ohio State's Ohio Agricultural Research and Development Center (OARDC).

"In addition to blocking their 'kidney' function, the chemical leaves mosquitoes unable to fly and in some cases severely bloated, all of which would lead to a shorter lifespan for the mosquitoes."

The article is the result of a collaborative project between Piermarini's laboratory, Jerod Denton's laboratory at Vanderbilt University, and Klaus Beyenbach's laboratory at Cornell University. Female mosquitoes rely on their "kidneys" (called Malpighian tubules) when consuming a human blood meal. They may ingest the equivalent of their body mass in blood, so they need to immediately get rid of the excess water and salt they consume. They achieve that by urinating on their host while they are still feeding.

As a result, Piermarini said, mosquitoes with impaired "kidney" function would be less likely to escape the human host and survive the ingestion of blood.

"With this important proof-of-concept study completed, our team is now in search of similar chemicals that will show a high potency for perturbing potassium channels in mosquitoes, but not those in humans and other animals," he said.

"If we can accomplish this goal, then we may uncover a new generation of insecticides for controlling 'resistant' mosquitoes and the spread of mosquito-borne diseases."

New methods for mosquito control are urgently needed, Piermarini said. Mosquitoes are becoming resistant to the insecticides currently used to combat the spread of diseases such as malaria, which kills close to 1 million people every year, and dengue, which infects hundreds of millions of people annually.

Piermarini's research is funded by a $1.4 million grant from the Foundation for the National Institutes of Health's "New Insecticides for Malaria Control" program, which is supported by the Bill & Melinda Gates Foundation.


Story Source:

The above story is based on materials provided by Ohio State University. The original article was written by Mauricio Espinoza. Note: Materials may be edited for content and length.


Journal Reference:

  1. Rene Raphemot, Matthew F. Rouhier, Corey R. Hopkins, Rocco D. Gogliotti, Kimberly M. Lovell, Rebecca M. Hine, Dhairyasheel Ghosalkar, Anthony Longo, Klaus W. Beyenbach, Jerod S. Denton, Peter M. Piermarini. Eliciting Renal Failure in Mosquitoes with a Small-Molecule Inhibitor of Inward-Rectifying Potassium Channels. PLoS ONE, 2013; 8 (5): e64905 DOI: 10.1371/journal.pone.0064905

Cite This Page:

Ohio State University. "Scientists find chemical that causes 'kidney' failure in mosquitoes." ScienceDaily. ScienceDaily, 29 May 2013. <www.sciencedaily.com/releases/2013/05/130529190944.htm>.
Ohio State University. (2013, May 29). Scientists find chemical that causes 'kidney' failure in mosquitoes. ScienceDaily. Retrieved September 19, 2014 from www.sciencedaily.com/releases/2013/05/130529190944.htm
Ohio State University. "Scientists find chemical that causes 'kidney' failure in mosquitoes." ScienceDaily. www.sciencedaily.com/releases/2013/05/130529190944.htm (accessed September 19, 2014).

Share This



More Plants & Animals News

Friday, September 19, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Chocolate Museum Opens in Brussels

Chocolate Museum Opens in Brussels

AFP (Sep. 19, 2014) Considered a "national heritage" in Belgium, chocolate now has a new museum in Brussels. In a former chocolate factory, visitors to the permanent exhibition spaces, workshops and tastings can discover derivatives of the cocoa bean. Duration: 01:00 Video provided by AFP
Powered by NewsLook.com
Could Grief Affect The Immune Systems Of Senior Citizens?

Could Grief Affect The Immune Systems Of Senior Citizens?

Newsy (Sep. 19, 2014) The study found elderly people are much more likely to become susceptible to infection than younger adults going though a similar situation. Video provided by Newsy
Powered by NewsLook.com
Jury Delivers Verdict in Salmonella Trial

Jury Delivers Verdict in Salmonella Trial

AP (Sep. 19, 2014) A federal jury has convicted three people in connection with an outbreak of salmonella poisoning five years ago that sickened hundreds of people and was linked to a number of deaths. (Sept. 19) Video provided by AP
Powered by NewsLook.com
Raw: Elephant Undergoes Surgery in Tbilisi Zoo

Raw: Elephant Undergoes Surgery in Tbilisi Zoo

AP (Sep. 18, 2014) Grand the elephant has successfully undergone surgery to remove a portion of infected tusk at Tbilisi Zoo in Georgia. British veterinary surgeons used an electric drill to extract the infected piece. (Sept. 18) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins