Featured Research

from universities, journals, and other organizations

Microwaves make for faster, greener pharma manufacturing

Date:
May 30, 2013
Source:
University of Bradford
Summary:
Microwave radiation could provide a faster, greener way to manufacture drugs, according to researchers.

Microwave radiation could provide a faster, greener way to manufacture drugs, according to researchers at the University of Bradford.

Published in the Royal Society of Chemistry journal, CrystEngComm, the research is the first to show that microwave radiation can be effectively used for co-crystallisation, a process which creates single crystals constructed from two compounds. Drugs manufactured from these 'co-crystals' can have improved properties such as longer shelf-life, improved solubility and easier absorption into a patient's bloodstream.

Using caffeine and maleic acid as example compounds, the researchers achieved 100 percent crystallisation in just one minute using very little solvent, making the process faster and more environmentally friendly than conventional methods.

Professor Paradkar, Director of the University of Bradford's Centre for Pharmaceutical Engineering, explains: "We chose caffeine and maleic acid as these compounds have different levels of solubility which is a common problem in pharmaceutical manufacturing. Conventional methods of co-crystallisation aren't effective when you're working with two compounds that dissolve differently, but we found that by using microwave radiation we could still get excellent results."

The team worked with five different solvents, of which water and methanol produced the best results. These two solvents were able to transmit the heat from microwave radiation more effectively than the others tested: acetone, ethyl acetate and toluene.

The experiments have only, to date, been carried out at laboratory scale, but Professor Paradkar believes that, if the process can be scaled up, it could offer significant benefits to the pharmaceutical industry:

"Other methods of co-crystallisation, such as solvent crystallisation, grinding or ultrasound, all have associated problems, for example increased use of solvents or lack of purity in the resulting co-crystals," he says. "Our research shows that microwave radiation is a very promising alternative for producing pure co-crystals quickly, with limited use of solvents."


Story Source:

The above story is based on materials provided by University of Bradford. Note: Materials may be edited for content and length.


Journal Reference:

  1. Sudhir Pagire, Sachin Korde, Rohan Ambardekar, Shivprasad Deshmukh, Radha Charan Dash, Ravindra Dhumal, Anant Paradkar. Microwave assisted synthesis of caffeine/maleic acid co-crystals: the role of the dielectric and physicochemical properties of the solvent. CrystEngComm, 2013; 15 (18): 3705 DOI: 10.1039/C3CE40292D

Cite This Page:

University of Bradford. "Microwaves make for faster, greener pharma manufacturing." ScienceDaily. ScienceDaily, 30 May 2013. <www.sciencedaily.com/releases/2013/05/130530094629.htm>.
University of Bradford. (2013, May 30). Microwaves make for faster, greener pharma manufacturing. ScienceDaily. Retrieved October 2, 2014 from www.sciencedaily.com/releases/2013/05/130530094629.htm
University of Bradford. "Microwaves make for faster, greener pharma manufacturing." ScienceDaily. www.sciencedaily.com/releases/2013/05/130530094629.htm (accessed October 2, 2014).

Share This



More Matter & Energy News

Thursday, October 2, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Japan Looks To Faster Future As Bullet Train Turns 50

Japan Looks To Faster Future As Bullet Train Turns 50

Newsy (Oct. 1, 2014) Japan's bullet train turns 50 Wednesday. Here's a look at how it's changed over half a century — and the changes it's inspired globally. Video provided by Newsy
Powered by NewsLook.com
US Police Put Body Cameras to the Test

US Police Put Body Cameras to the Test

AFP (Oct. 1, 2014) Police body cameras are gradually being rolled out across the US, with interest surging after the fatal police shooting in August of an unarmed black teenager. Duration: 02:18 Video provided by AFP
Powered by NewsLook.com
Raw: Japan Celebrates 'bullet Train' Anniversary

Raw: Japan Celebrates 'bullet Train' Anniversary

AP (Oct. 1, 2014) A ceremony marking 50 years since Japan launched its Shinkansen bullet train was held on Wednesday in Tokyo. The latest model can travel from Tokyo to Osaka, a distance of 319 miles, in two hours and 25 minutes. (Oct. 1) Video provided by AP
Powered by NewsLook.com
Robotic Hair Restoration

Robotic Hair Restoration

Ivanhoe (Oct. 1, 2014) A new robotic procedure is changing the way we transplant hair. The ARTAS robot leaves no linear scarring and provides more natural results. Video provided by Ivanhoe
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Space & Time

Matter & Energy

Computers & Math

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins