Featured Research

from universities, journals, and other organizations

Females fend off gut diseases -- at least among mice

Date:
June 11, 2013
Source:
Michigan State University
Summary:
At least among mice, females have innate protection from certain digestive conditions, according to a new study. While it's tricky to draw conclusions for human health, the findings could eventually help scientists better understand and treat the millions of people suffering from inflammatory bowel diseases.

A microscopic image shows an inflamed intestine in a male mouse. MSU professor Laura McCabe and colleagues found that something about female mice seems to protect them from inflammatory bowel disease.
Credit: Image courtesy of Michigan State University

At least among mice, females have innate protection from certain digestive conditions, according to a new Michigan State University study.

While it's tricky to draw conclusions for human health, the findings could eventually help scientists better understand and treat the 1.4 million Americans suffering from inflammatory bowel diseases, or IBD.

Crohn's disease and colitis, the two most common forms of IBD, involve abnormal functioning of the immune system that can damage the digestive tract, causing inflammation, diarrhea, constipation, abdominal pain and other symptoms.

For the study, researchers induced colitis by giving mice with weakened immune systems a dose of bacteria that can cause digestive trouble. After six weeks, the males had significantly more severe symptoms than the females and had more of the bacteria left in their guts. The males also showed more deterioration of their bones, which studies have linked to gut inflammation.

"It seems females are protected from bad bacteria-induced bone loss, and it's because they have reduced gut inflammation," said co-author Laura McCabe, a professor in the MSU Departments of Physiology and Radiology. "When we looked at markers of inflammation in the male mice, they were really high, whereas the females didn't have that kind of bad response. They can somehow handle these nasty bacteria."

McCabe said while the new study is a step toward better understanding of IBD, it's not clear if women have the same kind of resistance to the condition as the female mice. Indeed, much is still unknown about IBD, including what causes it. The imbalance of good and bad gut bacteria that the experiment simulated is one possible cause.

"We want to know what it is about female mice allowing them to be protected," she said. "If we can understand that, we might have a potential therapeutic target for people with IBD."

The study was funded by the Crohn's and Colitis Foundation of America and appears in the journal Inflammatory Bowel Diseases.

McCabe's partners on the study from the Department of Physiology were Regina Irwin, research technologist; Tae Hyung Lee, research associate; and Narayanan Parameswaran, associate professor. Vincent Young from the University of Michigan also participated.


Story Source:

The above story is based on materials provided by Michigan State University. Note: Materials may be edited for content and length.


Cite This Page:

Michigan State University. "Females fend off gut diseases -- at least among mice." ScienceDaily. ScienceDaily, 11 June 2013. <www.sciencedaily.com/releases/2013/06/130611122113.htm>.
Michigan State University. (2013, June 11). Females fend off gut diseases -- at least among mice. ScienceDaily. Retrieved October 22, 2014 from www.sciencedaily.com/releases/2013/06/130611122113.htm
Michigan State University. "Females fend off gut diseases -- at least among mice." ScienceDaily. www.sciencedaily.com/releases/2013/06/130611122113.htm (accessed October 22, 2014).

Share This



More Health & Medicine News

Wednesday, October 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Working Mother (Oct. 22, 2014) Is your child ready? Video provided by Working Mother
Powered by NewsLook.com
U.S. Issues Ebola Travel Restrictions, Are Visa Bans Next?

U.S. Issues Ebola Travel Restrictions, Are Visa Bans Next?

Newsy (Oct. 22, 2014) Now that the U.S. is restricting travel from West Africa, some are dropping questions about a travel ban and instead asking about visa bans. Video provided by Newsy
Powered by NewsLook.com
US to Track Everyone Coming from Ebola Nations

US to Track Everyone Coming from Ebola Nations

AP (Oct. 22, 2014) Stepping up their vigilance against Ebola, federal authorities said Wednesday that everyone traveling into the US from Ebola-stricken nations will be monitored for symptoms for 21 days. (Oct. 22) Video provided by AP
Powered by NewsLook.com
Doctors Help Paralysed Man Walk Again, Patient in Disbelief

Doctors Help Paralysed Man Walk Again, Patient in Disbelief

AFP (Oct. 22, 2014) Polish doctors describe how they helped a paralysed man walk again, with the patient in disbelief at the return of sensation to his legs. Duration: 1:04 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins