Featured Research

from universities, journals, and other organizations

U-shaped curve revealed for association between fish consumption and atrial fibrillation

Date:
June 24, 2013
Source:
European Society of Cardiology (ESC)
Summary:
Moderation seems to be key when it comes to eating fish to prevent atrial fibrillation (AF) according to a new study.

Moderation seems to be key when it comes to eating fish to prevent atrial fibrillation (AF) according to an observational study presented at the EHRA EUROPACE congress held 23 to 26 June in Athens, Greece.

The study found a U-shaped association between consumption of marine n-3 polyunsaturated fatty acids (n-3 PUFA) and the risk of developing AF, with people who have both low and high intakes found to suffer more from AF than those with median intakes. The lowest risk of AF was found in those who consumed around 0.63 g marine n-3 PUFA per day, which corresponds to around two servings of fatty (oily) fish per week.

Earlier studies have reported that regular consumption of fish can exert beneficial effects in preventing the development of AF. Notably, in the Cardiovascular Health study², which included 4,815 participants, a 28% lower risk of AF was observed among people who consumed fish one to four times per week compared with those who ate fish less than once per month. However, such observed associations have not been confirmed in all cohort studies³?8.

In the current study, Doctor Thomas Rix and colleagues from Aalborg University Hospital in Denmark, set out to examine the hypothesis that a negative association exists between the development of AF and consumption of n-3 PUFA. "Since AF is present in over six million people in Europe and associated with considerable morbidity, mortality and economic costs, preventing AF by achievable dietary changes would be of major public interest," said Dr. Rix.

The investigators made use of the Danish Diet, Cancer and Health cohort 9, which between 1993 and 1997 enrolled a total of 57,053 Danish participants aged 50 to 64 years. The study, funded by the Danish Cancer society, had been initiated with the primary objective of exploring the role of diet in the development of cancer. Baseline data recorded for the study included a semi quantitative food frequency questionnaire with detailed questions about the consumption of fish and food products containing fish that enabled the calculation of average n-3 PUFA intakes. Levels of N-3 PUFA/day were divided into quintiles: with quintile 1 representing 0.00-0.38g marine n-3 PUFA/ day; quintile 2 representing 0.39-0.53g marine n-3 PUFA/day; quintile 3 representing 0.54 to 0.73 g marine n-3 PUFA/day; quintile 4 0.74 to 0.99 g marine n-3 PUFA/day; and quintile 5 1.00-7.22 g marine n-3 PUFA/day.

Follow-up of AF events in the population was undertaken using the Danish National Patient Registry, which recorded discharge diagnoses from hospital admissions, emergency rooms and outpatient clinics. The registry was facilitated by the Danish practice of identifying every citizen with a unique personal identification number that enables cross links to be made between different national registries.

Altogether a total of 3,425 incident cases of AF were registered during 13.6 years of follow-up. When data was analysed in a multivariate Cox regression model, in comparison to the lowest quintile a 9% lower risk of AF was seen for the second quintile (HR 0.91 95% CI 0.81-1.02); a 13 % lower risk of AF was seen for the third quintile (HR 0.87, 95% CI 0.78-0.98, p=0.02); a 4% lower rate was seen for the fourth quintile (HR 0.96, 95% CI 0.86-1.07) and a 3% increased rate was seen for the 5th quintile (HR 1.03, 95% CI 0.92-1.15).

"The 13% observed lower risk of AF seen at moderate intakes of marine n-3 PUFA compared with low intakes may be related to a reduction in ischemic heart disease and anti-inflammatory effects in addition to direct anti arrhythmic effects," said Dr. Rix. He noted that in one study, treatment with 1.8g n-3PUFA/day in patients with low intakes of fish resulted in prolongation of the atrial effective refractory period and less inducible AF, both in subjects with AF8 and subjects without AF10.

The biological mechanisms behind the higher risk of AF observed for high intakes of n-3 PUFA compared to moderate intakes were more difficult to explain," said Dr. Rix. "We can only speculate that the balance between AF inhibiting and AF promoting effects can change according to co morbidities and intakes of marine n-3PUFA. This is the first time that such an association has been shown and it needs to be explored in further studies. However, it may help explain some of the contradictory results obtained in earlier studies."


Story Source:

The above story is based on materials provided by European Society of Cardiology (ESC). Note: Materials may be edited for content and length.


Cite This Page:

European Society of Cardiology (ESC). "U-shaped curve revealed for association between fish consumption and atrial fibrillation." ScienceDaily. ScienceDaily, 24 June 2013. <www.sciencedaily.com/releases/2013/06/130624104210.htm>.
European Society of Cardiology (ESC). (2013, June 24). U-shaped curve revealed for association between fish consumption and atrial fibrillation. ScienceDaily. Retrieved August 28, 2014 from www.sciencedaily.com/releases/2013/06/130624104210.htm
European Society of Cardiology (ESC). "U-shaped curve revealed for association between fish consumption and atrial fibrillation." ScienceDaily. www.sciencedaily.com/releases/2013/06/130624104210.htm (accessed August 28, 2014).

Share This




More Health & Medicine News

Thursday, August 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Killer Amoeba Found in Louisiana Water System

Killer Amoeba Found in Louisiana Water System

AP (Aug. 28, 2014) — State health officials say testing has confirmed the presence of a killer amoeba in a water system serving three St. John the Baptist Parish towns. (Aug. 28) Video provided by AP
Powered by NewsLook.com
Who Could Be Burnt by WHO's E-Cigs Move?

Who Could Be Burnt by WHO's E-Cigs Move?

Reuters - Business Video Online (Aug. 28, 2014) — The World Health Organisation has called for the regulation of electronic cigarettes as both tobacco and medical products. Ciara Lee looks at the impact of the move on the tobacco industry. Video provided by Reuters
Powered by NewsLook.com
CDC Director On Ebola Outbreak: 'It's Worse Than I Feared'

CDC Director On Ebola Outbreak: 'It's Worse Than I Feared'

Newsy (Aug. 28, 2014) — CDC director Tom Frieden says the Ebola outbreak is even worse than he feared. But he also said there's still hope to contain it. Video provided by Newsy
Powered by NewsLook.com
How A 'Rule Of Thumb' Could Slow Down Drinking

How A 'Rule Of Thumb' Could Slow Down Drinking

Newsy (Aug. 28, 2014) — A study suggests people who follow a "rule of thumb" when pouring wine dispense less than those who don't have a particular amount in mind. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins