Featured Research

from universities, journals, and other organizations

Acid reflux surgery could help prevent rejection in lung transplant patients

Date:
June 28, 2013
Source:
Loyola University Health System
Summary:
A procedure to treat acid reflux could help prevent chronic rejection in lung transplant patients, according to a new study.

A Loyola University Medical Center study suggests that a procedure to treat acid reflux could help prevent chronic rejection in lung transplant patients.

The study also found that certain proteins found in lung fluid can help predict whether a patient's transplanted lung is more likely to fail.

Results are published in the July 2013 issue of the Journal of the American College of Surgeons. Authors are P. Marco Fisichella, MD, FACS (first author), Christopher S. Davis, MD, MPH; Erin Lowery, MD, MS; Luis Ramirez, BS; Richard L. Gamelli, MD, FACS and Elizabeth J. Kovacs, PhD.

Lung transplant patients have the worst survivals of all solid organ transplant recipients. A major reason is bronchiolitis obliterans syndrome (BOS), a condition in which scar tissue forms around small airways in the lungs. BOS results from chronic rejection of the transplanted lung, and affects about half of lung transplant patients within five years.

Following lung transplantation, patients undergo a procedure every few months to inspect the airways. The procedure, called a bronchoscopy, removes fluid from the lung.

Loyola researchers analysed various biomarkers taken from lung fluid during bronchoscopies. Researchers found that, in patients examined 6 to 12 months after transplant, concentrations of certain biomarkers could predict the likelihood of BOS 30 months after transplant. For example, patients with high concentrations of the biomarker myeloperoxidase and low concentrations of the biomarker α-1 antitrypsin were more likely to develop BOS.

The study also found that patients who aspirate (inhale fluid into the lungs) show evidence of a more active immune system. In a condition called acid reflux, gastric contents back up from the stomach into the esophagus and can be inhaled into the lungs. The gastric contents irritate the lungs, triggering the immune system to ramp up and begin rejecting the transplanted lung. As evidence of this, patients who aspirate showed higher levels of neutrophils (a type of immune system white blood cell) and the immune system biomarker interleukin-8 (IL-8).

A minimally invasive procedure called laparoscopic anti-reflux surgery can treat acid reflux. The surgeon reinforces the valve between the esophagus and stomach by wrapping the upper portion of the stomach around the lowest portion of the esophagus. The 90-minute procedure requires five small incisions. Patients typically go home the next day, and take about one week to recover, Fisichella said.

Researchers wrote that their findings "justify the surgical prevention of aspiration and argue for the refinement of antirejection regimens."


Story Source:

The above story is based on materials provided by Loyola University Health System. Note: Materials may be edited for content and length.


Journal Reference:

  1. P. Marco Fisichella, Christopher S. Davis, Erin Lowery, Luis Ramirez, Richard L. Gamelli, Elizabeth J. Kovacs. Aspiration, Localized Pulmonary Inflammation, and Predictors of Early-Onset Bronchiolitis Obliterans Syndrome after Lung Transplantation. Journal of the American College of Surgeons, 2013; 217 (1): 90 DOI: 10.1016/j.jamcollsurg.2013.03.008

Cite This Page:

Loyola University Health System. "Acid reflux surgery could help prevent rejection in lung transplant patients." ScienceDaily. ScienceDaily, 28 June 2013. <www.sciencedaily.com/releases/2013/06/130628103147.htm>.
Loyola University Health System. (2013, June 28). Acid reflux surgery could help prevent rejection in lung transplant patients. ScienceDaily. Retrieved September 22, 2014 from www.sciencedaily.com/releases/2013/06/130628103147.htm
Loyola University Health System. "Acid reflux surgery could help prevent rejection in lung transplant patients." ScienceDaily. www.sciencedaily.com/releases/2013/06/130628103147.htm (accessed September 22, 2014).

Share This



More Health & Medicine News

Monday, September 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Liberia Pleads for Help to Fight Ebola

Liberia Pleads for Help to Fight Ebola

AP (Sep. 22, 2014) Liberia's finance minister is urging the international community to quickly follow through on pledges of cash to battle Ebola. Bodies are piling up in the capital Monrovia as the nation awaits more help. (Sept. 22) Video provided by AP
Powered by NewsLook.com
Global Ebola Aid Increasing But Critics Say It's Late

Global Ebola Aid Increasing But Critics Say It's Late

Newsy (Sep. 21, 2014) More than 100 tons of medical supplies were sent to West Africa on Saturday, but aid workers say the global response is still sluggish. Video provided by Newsy
Powered by NewsLook.com
Sierra Leone in Lockdown to Control Ebola

Sierra Leone in Lockdown to Control Ebola

AP (Sep. 21, 2014) Sierra Leone residents remained in lockdown on Saturday as part of a massive effort to confine millions of people to their homes in a bid to stem the biggest Ebola outbreak in history. (Sept. 20) Video provided by AP
Powered by NewsLook.com
Sierra Leone's Nationwide Ebola Curfew Underway

Sierra Leone's Nationwide Ebola Curfew Underway

Newsy (Sep. 20, 2014) Sierra Leone is locked down as aid workers and volunteers look for new cases of Ebola. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins