Featured Research

from universities, journals, and other organizations

Mathematical models target disease with drugs chosen by your DNA

Date:
July 16, 2013
Source:
Penn State
Summary:
Medicines that are personally tailored to your DNA are becoming a reality, thanks to the work of U.S. and Chinese scientists who developed statistical models to predict which drug is best for a specific individual with a specific disease.

Medicines that are personally tailored to your DNA are becoming a reality, thanks to the work of U.S. and Chinese scientists who developed statistical models to predict which drug is best for a specific individual with a specific disease.

Related Articles


"Traditional medicine doesn't consider mechanistic drug response," said Rongling Wu, director of the Center for Statistical Genetics and professor of public health sciences within the division of biostatistics and bioinformatics at the Penn State College of Medicine. "We want to look at how an individual person responds to an individual drug by deriving and using sophisticated mathematical models, such as differential equations."

The current method of prescribing medication now sometimes includes a pharmacogenomic approach, but researchers recognize the limitation of this approach in predicting a response to a particular drug and dosage combination.

Pharmacogenomics uses a person's genes to explain the difference between how one person responds to a drug compared to another. The team's equations take this field one step further by also including information about how the body processes a drug and how the drug acts in the body.

Wu focused on the big picture by studying drug response and drug reaction. In particular, the team looked at pharmacokinetics, which influences the concentration of a drug reaching its target, and pharmacodynamics, which determines the drug response. Metabolic, environmental and developmental factors also play a role in medication response.

The researchers created a statistical analysis framework of differential equations that they expect will help doctors and pharmacists, by simulating such variables as protein-protein and protein-DNA interactions a drug has in a patient. The framework characterizes a drug's absorption, distribution and elimination properties, yielding information on pharmacological targets, physiological pathways and, ultimately, disease systems in patients, resulting in predictions of treatment effectiveness.

"The results from this framework will facilitate the quantitative prediction of the responses of individual subjects as well as the design of optimal drug treatments," the researchers noted in a recent special issue of Advanced Drug Discovery Reviews.

This framework will expand to shed light on the variability of drug response based on information the medical community continues to gather about how an individual responds to a particular drug and dose combination. The information collected is then combined with information about the patient's genes, proteins and metabolism to help determine what drug and dose might be best for that person.

"If we know how genes control drug response, we can create a statistical model that shows us what will happen before using the drug," said Wu, who is also a member of Penn State's Huck Institutes of the Life Sciences. This means a future with more effective medications, faster healing and fewer side effects. "That is our final goal," Wu said.

Working with Wu were Yaqun Wang and Ningtao Wang, both graduate students in the Center for Statistical Genetics at Penn State; and Jianxin Wang, professor, information science, and Zhong Wang, computer scientist, both at the Center for Computational Biology at Beijing Forestry University.

The National Center for Advancing Translational Sciences of the National Institutes of Health supported this research.


Story Source:

The above story is based on materials provided by Penn State. The original article was written by Victoria M. Indivero. Note: Materials may be edited for content and length.


Journal Reference:

  1. Yaqun Wang, Ningtao Wang, Jianxin Wang, Zhong Wang, Rongling Wu. Delivering systems pharmacogenomics towards precision medicine through mathematics. Advanced Drug Delivery Reviews, 2013; 65 (7): 905 DOI: 10.1016/j.addr.2013.03.002

Cite This Page:

Penn State. "Mathematical models target disease with drugs chosen by your DNA." ScienceDaily. ScienceDaily, 16 July 2013. <www.sciencedaily.com/releases/2013/07/130716120030.htm>.
Penn State. (2013, July 16). Mathematical models target disease with drugs chosen by your DNA. ScienceDaily. Retrieved October 25, 2014 from www.sciencedaily.com/releases/2013/07/130716120030.htm
Penn State. "Mathematical models target disease with drugs chosen by your DNA." ScienceDaily. www.sciencedaily.com/releases/2013/07/130716120030.htm (accessed October 25, 2014).

Share This



More Health & Medicine News

Saturday, October 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Texas Nurse Nina Pham Cured of Ebola

Texas Nurse Nina Pham Cured of Ebola

AFP (Oct. 25, 2014) — An American nurse who contracted Ebola while caring for a Liberian patient in Texas has been declared free of the virus and will leave the hospital. Duration: 01:01 Video provided by AFP
Powered by NewsLook.com
IKEA Desk Converts From Standing to Sitting With One Button

IKEA Desk Converts From Standing to Sitting With One Button

Buzz60 (Oct. 24, 2014) — IKEA is out with a new convertible desk that can convert from a sitting desk to a standing one with just the push of a button. Jen Markham explains. Video provided by Buzz60
Powered by NewsLook.com
Ebola Protective Suits Being Made in China

Ebola Protective Suits Being Made in China

AFP (Oct. 24, 2014) — A factory in China is busy making Ebola protective suits for healthcare workers and others fighting the spread of the virus. Duration: 00:38 Video provided by AFP
Powered by NewsLook.com
WHO: Millions of Ebola Vaccine Doses by 2015

WHO: Millions of Ebola Vaccine Doses by 2015

AP (Oct. 24, 2014) — The World Health Organization said on Friday that millions of doses of two experimental Ebola vaccines could be ready for use in 2015 and five more experimental vaccines would start being tested in March. (Oct. 24) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins