Featured Research

from universities, journals, and other organizations

BPA and chlorine means bad news: Modified forms of bisphenol A found to alter hormone signaling in new, disturbing ways

Date:
July 17, 2013
Source:
University of Texas Medical Branch at Galveston
Summary:
The ubiquity of the endocrine-disrupting chemical bisphenol A led researchers to ask what it might be doing in publicly supplied, chlorinated drinking water. The answer: Chlorinated BPA has different, but no less profound effects on cell-signaling networks than unmodified BPA.

The ubiquity of the endocrine-disrupting chemical bisphenol A led researchers to ask what it might be doing in publicly supplied, chlorinated drinking water. The answer: Chlorinated BPA has different, but no less profound effects on cell-signaling networks than unmodified BPA.
Credit: © Artusius / Fotolia

The ubiquity of the endocrine-disrupting chemical bisphenol A led researchers to ask what it might be doing in publicly supplied, chlorinated drinking water. The answer: Chlorinated BPA has different, but no less profound effects on cell-signaling networks than unmodified BPA.

For years, scientists have been worried about bisphenol A. The chemical is known as an "endocrine disruptor," a substance that interferes with the body's hormone signaling system, and it's found in everything from plastic drink bottles to the linings of food and drink cans to the thermal paper used for cash register receipts -- not to mention the urine of 92.6 percent of Americans over the age of six. BPA has been associated with the development of chronic diseases such as diabetes, asthma and ovarian dysfunction. In 2012, the FDA banned BPA from use in the production of baby bottles and drinking cups.

BPA's ubiquity in the environment led researchers to ask what it might be doing in publicly supplied drinking water, which is contaminated at its source by BPA-laden discarded plastic and later picks up more of the chemical when it passes through PVC plastic pipes. Most public water supplies are chlorinated to kill bacteria, and the BPA in the water also becomes chlorinated, acquiring one or more chlorine atoms from the water around it. The question was, how does this chlorinated BPA behave in the body?

The answer, generated from cell-culture experiments, was that it produced different but no less profound effects. "We found that when you modify the BPA it works just as dramatically but in different ways on the same systems," said University of Texas Medical Branch at Galveston professor Cheryl Watson, senior author of a paper on the study now online in Endocrine Disruptors.

Watson and graduate student René Viñas examined both chlorinated BPA and BPA that had undergone sulfonation and glucuronodation -- two processes the body uses to make a compound easier to excrete. In all three cases the modified forms of BPA worked through membrane estrogen receptors to deactivate key signaling enzymes known as ERK and JNK kinases.

"These kinases are major control centers, gathering all the cell signals, making decisions and then expediting them," Watson said. "If you change the dynamic by inactivating kinases, you can mess up cell signaling."

Very low levels of modified BPA were sufficient to produce the results -- a phenomenon commonly seen with membrane receptors. The responses followed what is known as a non-monotonic pattern, varying irregularly when different concentrations of modified BPA were tested. The large number of experimental procedures this made necessary were facilitated by a BIOMEK-FX robot, which Viñas programmed to considerably increase the efficiency and precision of the process.

"The robot cuts down on the experimenter time required, because it does so much of the mechanical work, and it makes results more replicable, because the robot does things exactly the same every time," Watson said. "It gives us hope that we can make an impact even with the sheer volume of chemicals that we have to study and the detail we have to study them in."


Story Source:

The above story is based on materials provided by University of Texas Medical Branch at Galveston. Note: Materials may be edited for content and length.


Journal Reference:

  1. René Viñas, Randall M. Goldblum, Cheryl S. Watson. Rapid estrogenic signaling activities of the modified (chlorinated, sulfonated, and glucuronidated) endocrine disruptor bisphenol A. Endocrine Disruptors, 2013 [link]

Cite This Page:

University of Texas Medical Branch at Galveston. "BPA and chlorine means bad news: Modified forms of bisphenol A found to alter hormone signaling in new, disturbing ways." ScienceDaily. ScienceDaily, 17 July 2013. <www.sciencedaily.com/releases/2013/07/130717132420.htm>.
University of Texas Medical Branch at Galveston. (2013, July 17). BPA and chlorine means bad news: Modified forms of bisphenol A found to alter hormone signaling in new, disturbing ways. ScienceDaily. Retrieved July 25, 2014 from www.sciencedaily.com/releases/2013/07/130717132420.htm
University of Texas Medical Branch at Galveston. "BPA and chlorine means bad news: Modified forms of bisphenol A found to alter hormone signaling in new, disturbing ways." ScienceDaily. www.sciencedaily.com/releases/2013/07/130717132420.htm (accessed July 25, 2014).

Share This




More Earth & Climate News

Friday, July 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Goma Cheese Brings Whiff of New Hope to DRC

Goma Cheese Brings Whiff of New Hope to DRC

Reuters - Business Video Online (July 24, 2014) — The eastern region of the Democratic Republic of Congo, mainly known for conflict and instability, is an unlikely place for the production of fine cheese. But a farm in the village of Masisi, in North Kivu is slowly transforming perceptions of the area. Known simply as Goma cheese, the Congolese version of Dutch gouda has gained popularity through out the region. Ciara Sutton reports. Video provided by Reuters
Powered by NewsLook.com
Bill Gates: Health, Agriculture Key to Africa's Development

Bill Gates: Health, Agriculture Key to Africa's Development

AFP (July 24, 2014) — Health and agriculture development are key if African countries are to overcome poverty and grow, US software billionaire Bill Gates said Thursday, as he received an honourary degree in Ethiopia. Duration: 00:36 Video provided by AFP
Powered by NewsLook.com
Higgins Breaks Record at Mt. Washington

Higgins Breaks Record at Mt. Washington

Driving Sports (July 24, 2014) — Subaru Rally Team USA drivers David Higgins and Travis Pastrana face off against a global contingent of racers at the annual Mt. Washington Hillclimb in New Hampshire. Includes exclusive in-car footage from Higgins' record attempt. Video provided by Driving Sports
Powered by NewsLook.com
Storm Kills Three, Injures 20 at Virginia Campground

Storm Kills Three, Injures 20 at Virginia Campground

Reuters - US Online Video (July 24, 2014) — A likely tornado tears through an eastern Virginia campground, killing three and injuring at least 20. Linda So reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

    Health News

      Environment News

        Technology News



          Save/Print:
          Share:  

          Free Subscriptions


          Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

          Get Social & Mobile


          Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

          Have Feedback?


          Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
          Mobile iPhone Android Web
          Follow Facebook Twitter Google+
          Subscribe RSS Feeds Email Newsletters
          Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins