Featured Research

from universities, journals, and other organizations

Gene that may stop the spread of breast cancer identified

Date:
July 23, 2013
Source:
Rutgers Robert Wood Johnson Medical School
Summary:
In cancer, the spread of tumor cells from the primary site to other parts of the body is called metastasis and is a major cause of death, especially in patients with breast cancer. A new study shows that metastasis in breast cancer and the risk of death are reduced when the function of the gene HGMA2, is limited.

In cancer, the spread of tumor cells from the primary site to other parts of the body is called metastasis and is a major cause of death, especially in patients with breast cancer. A new study by Kiran Chada, PhD, professor of biochemistry and molecular biology at Robert Wood Johnson Medical School, part of Rutgers, The State University of New Jersey, shows that metastasis in breast cancer and the risk of death are reduced when the function of the gene HGMA2, is limited.

Related Articles


This finding, published in Cancer Research, a journal of the American Association for Cancer Research (AACR), may be used to develop therapeutic treatments for patients.

"Our research has shown that HGMA2 plays a part in regulating the spread of cancer and could be considered a driver of the process," said Dr. Chada, who was principal investigator of the study. "Further studies could result in the development of therapeutic treatments for patients with breast cancer which could prevent HGMA2's function, reduce the spread of cancer and extend a patient's life."

According to Dr. Chada, only a subset of cancer cells in the primary tumor is potentially metastatic and these cells are found at the edge of the tumor in a region known as the invasive front. Dr. Chada's laboratory showed that normal cells do not express HMGA2, and the expression of this gene product converts normal cells into metastatic cells. Furthermore, the majority of cells which express HMGA2 in human breast cancer tissue were found to be at the invasive front. In additional studies, the researchers showed mice that could not express the HMGA2 gene were found to have a substantially reduced incidence of breast cancer.

Dr. Chada's laboratory conducted the research along with the laboratory of Jeanine D' Armiento, MD, PhD, assistant professor of medicine at Columbia University Funding for the study was provided by grants from the Columbia University LAM Center and the National Heart, Lung and Blood Institute of the National Institutes of Health.


Story Source:

The above story is based on materials provided by Rutgers Robert Wood Johnson Medical School. Note: Materials may be edited for content and length.


Journal Reference:

  1. A. Morishita, M. R. Zaidi, A. Mitoro, D. Sankarasharma, M. Szabolcs, Y. Okada, J. D'Armiento, K. Chada. HMGA2 Is a Driver of Tumor Metastasis. Cancer Research, 2013; 73 (14): 4289 DOI: 10.1158/0008-5472.CAN-12-3848

Cite This Page:

Rutgers Robert Wood Johnson Medical School. "Gene that may stop the spread of breast cancer identified." ScienceDaily. ScienceDaily, 23 July 2013. <www.sciencedaily.com/releases/2013/07/130723134252.htm>.
Rutgers Robert Wood Johnson Medical School. (2013, July 23). Gene that may stop the spread of breast cancer identified. ScienceDaily. Retrieved March 29, 2015 from www.sciencedaily.com/releases/2013/07/130723134252.htm
Rutgers Robert Wood Johnson Medical School. "Gene that may stop the spread of breast cancer identified." ScienceDaily. www.sciencedaily.com/releases/2013/07/130723134252.htm (accessed March 29, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, March 29, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

S. Leone in New Anti-Ebola Lockdown

S. Leone in New Anti-Ebola Lockdown

AFP (Mar. 28, 2015) — Sierra Leone imposed a three-day nationwide lockdown Friday for the second time in six months in a bid to prevent a resurgence of the deadly Ebola virus. Duration: 01:17 Video provided by AFP
Powered by NewsLook.com
These Popular Antibiotics Can Cause Permanent Nerve Damage

These Popular Antibiotics Can Cause Permanent Nerve Damage

Newsy (Mar. 27, 2015) — A popular class of antibiotic can leave patients in severe pain and even result in permanent nerve damage. Video provided by Newsy
Powered by NewsLook.com
WH Plan to Fight Antibiotic-Resistant Germs

WH Plan to Fight Antibiotic-Resistant Germs

AP (Mar. 27, 2015) — The White House on Friday announced a five-year plan to fight the threat posed by antibiotic-resistant bacteria amid fears that once-treatable germs could become deadly. (March 27) Video provided by AP
Powered by NewsLook.com
House Ready to Pass Medicare Doc Bill

House Ready to Pass Medicare Doc Bill

AP (Mar. 26, 2015) — In rare bipartisan harmony, congressional leaders pushed a $214 billion bill permanently blocking physician Medicare cuts toward House passage Thursday, moving lawmakers closer to resolving a problem that has plagued them for years. (March 26) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins