Featured Research

from universities, journals, and other organizations

Number one source for new teeth

Date:
July 29, 2013
Source:
BioMed Central Limited
Summary:
Stem cells derived from urine can be used to generate tooth-like structures, reports a new study. It’s thought the technique might one day help researchers grow new, tailor-made teeth for dental patients. That stem cells can be generated from urine is not new; previous studies have shown that cells discarded in human urine can be coaxed to become induced pluripotent stem cells (iPSCs), which themselves can generate many different cell types, including neurons and heart muscle cells. But researchers had yet to generate solid organs or tissues from iPSCs – until now.

Stem cells derived from urine can be used to generate tooth-like structures, reports a study published this week in the open access Cell Regeneration Journal. It's thought the technique might one day help researchers grow new, tailor-made teeth for dental patients.

That stem cells can be generated from urine is not new; previous studies have shown that cells discarded in human urine can be coaxed to become induced pluripotent stem cells (iPSCs), which themselves can generate many different cell types, including neurons and heart muscle cells. But researchers had yet to generate solid organs or tissues from iPSCs -- until now.

Duanqing Pei and colleagues have developed a novel chimeric tissue culture system to coax human urine-derived iPSCs into tiny structures that resemble teeth. The system mimics normal tooth development, which results from an interaction between two different cell types; epithelial cells, which give rise to enamel, and mesenchymal cells, which give rise to the other three main components of teeth (dentin, cementum and pulp).

First, the team used chemicals to coax the cultured iPSCs into flat sheets of epithelial cells. They then mixed these cells with mouse embryonic mesenchymal cells, and transplanted them into mice. Three weeks later, tooth-like structures had grown.

The primitive teeth-like organs are structurally and physically similar to human teeth. They are of roughly the same elasticity, and contain pulp, dentin and enamel-forming cells. But the method has its limitations -- it involves mouse cells, has a success rate of around 30% and the structures were about one-third of the hardness of human teeth.

To resolve these issues, human mesenchymal stem cells could be substituted for mouse ones and the tissue culture conditions tweaked. The revised method could, in theory, be used to create a bioengineered tooth bud that could be cultured in vitro then transplanted into the jawbone of a needy patient to form a fully functional tooth.

iPSCs are of interest over embryonic stem cells because their derivation avoids the controversial use of embryos. iPSCs have previously been derived from cultured skin and blood cells, but urine represents an more readily accessible source. Cells generated by this method would not be rejected by the host recipient, as they would be derived from the host's own cellular material. iPSCs remain a great source of hope for regenerative medicine.


Story Source:

The above story is based on materials provided by BioMed Central Limited. Note: Materials may be edited for content and length.


Journal Reference:

  1. Jinglei Cai, Yanmei Zhang, Pengfei Liu, Shubin Chen, Xuan Wu, Yuhua Sun, Ang Li, Ke Huang, Rongping Luo, Lihui Wang, Ying Liu, Ting Zhou, Shicheng Wei, Guangjin Pan, Duanqing Pei. Generation of tooth-like structures from integration-free human urine induced pluripotent stem cells. Cell Regeneration, 2013; 2 (1): 6 DOI: 10.1186/2045-9769-2-6

Cite This Page:

BioMed Central Limited. "Number one source for new teeth." ScienceDaily. ScienceDaily, 29 July 2013. <www.sciencedaily.com/releases/2013/07/130729231429.htm>.
BioMed Central Limited. (2013, July 29). Number one source for new teeth. ScienceDaily. Retrieved September 16, 2014 from www.sciencedaily.com/releases/2013/07/130729231429.htm
BioMed Central Limited. "Number one source for new teeth." ScienceDaily. www.sciencedaily.com/releases/2013/07/130729231429.htm (accessed September 16, 2014).

Share This



More Health & Medicine News

Tuesday, September 16, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

EU Ministers and Experts Meet to Discuss Ebola Reponse

EU Ministers and Experts Meet to Discuss Ebola Reponse

AFP (Sep. 15, 2014) The European Commission met on Monday to coordinate aid that the EU can offer to African countries affected by the Ebola outbreak. Duration: 00:58 Video provided by AFP
Powered by NewsLook.com
Despite The Risks, Antibiotics Still Overprescribed For Kids

Despite The Risks, Antibiotics Still Overprescribed For Kids

Newsy (Sep. 15, 2014) A new study finds children are prescribed antibiotics twice as often as is necessary. Video provided by Newsy
Powered by NewsLook.com
FDA Eyes Skin Shocks Used at Mass. School

FDA Eyes Skin Shocks Used at Mass. School

AP (Sep. 15, 2014) The FDA is considering whether to ban devices used by the Judge Rotenberg Educational Center in Canton, Massachusetts, the only place in the country known to use electrical skin shocks as aversive conditioning for aggressive patients. (Sept. 15) Video provided by AP
Powered by NewsLook.com
Respiratory Virus Spreads To Northeast, Now In 21 States

Respiratory Virus Spreads To Northeast, Now In 21 States

Newsy (Sep. 14, 2014) The respiratory virus Enterovirus D68, which targets children, has spread from the Midwest to 21 states. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins