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Probiotics do not prevent relapse in Crohn's disease patients

Date:
August 14, 2013
Source:
American Gastroenterological Association
Summary:
Despite previous data showing beneficial effects, the probiotic Saccharomuces boulardii does not prevent clinical relapse in patients with Crohn's disease.

Despite previous data showing beneficial effects, the probiotic Saccharomuces boulardii (S. boulardii) does not prevent clinical relapse in patients with Crohn's disease, according to a new study in Clinical Gastroenterology and Hepatology, the official clinical practice journal of the American Gastroenterological Association.

As more people seek natural or non-drug ways to maintain their health, products containing probiotics have flooded the marketplace. While safe and tolerable, this study discovered that the probiotic S. boulardii does not appear to have any significant beneficial effects for patients with Crohn's disease who are already in remission.

In this randomized, double-blind, placebo-controlled trial, the probiotic yeast S. boulardii was tested as a preventive therapy in patients with moderately severe Crohn's disease who were currently in remission following steroid or salicylate therapies. At the end of the one-year follow-up period, 50 percent of patients had relapsed -- 47.5 percent in the S. boulardii group and, similarly, 53.2 percent in the placebo group. Further, the time-to-relapse was not statistically different between patients treated with S. boulardii or placebo.

While this probiotic showed no positive effects for Crohn's disease patients, further studies are needed to determine the potential therapeutic efficacy of probiotics in other forms of IBD, such as ulcerative colitis, and pouchitis.

Probiotics are living microscopic organisms, or microorganisms, that scientific research has shown to benefit an individual's health. S. boulardii, a probiotic made from a strain of yeast and sold in local drug stores or supermarkets in the form of capsules, has been demonstrated to be effective in the treatment of traveler's diarrhea, diarrhea occurring in subjects infected with the human immunodeficiency virus and the prevention of diarrhea associated with antibiotics.


Story Source:

The above story is based on materials provided by American Gastroenterological Association. Note: Materials may be edited for content and length.


Journal Reference:

  1. Arnaud Bourreille, Guillaume Cadiot, Gιrard Le Dreau, David Laharie, Laurent Beaugerie, Jean–Louis Dupas, Philippe Marteau, Patrick Rampal, Dominique Moyse, Ashraf Saleh, Marie–Emmanuelle Le Guern, Jean–Paul Galmiche. Saccharomyces boulardii Does Not Prevent Relapse of Crohn's Disease. Clinical Gastroenterology and Hepatology, 2013; 11 (8): 982 DOI: 10.1016/j.cgh.2013.02.021

Cite This Page:

American Gastroenterological Association. "Probiotics do not prevent relapse in Crohn's disease patients." ScienceDaily. ScienceDaily, 14 August 2013. <www.sciencedaily.com/releases/2013/08/130814124738.htm>.
American Gastroenterological Association. (2013, August 14). Probiotics do not prevent relapse in Crohn's disease patients. ScienceDaily. Retrieved August 28, 2014 from www.sciencedaily.com/releases/2013/08/130814124738.htm
American Gastroenterological Association. "Probiotics do not prevent relapse in Crohn's disease patients." ScienceDaily. www.sciencedaily.com/releases/2013/08/130814124738.htm (accessed August 28, 2014).

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