Featured Research

from universities, journals, and other organizations

Newly discovered weakness in cancer cells make them more susceptible to chemotherapy

Date:
August 29, 2013
Source:
Federation of American Societies for Experimental Biology
Summary:
A new weakness discovered in cancer cells may cause increased susceptibility to chemotherapy and other treatments. Researchers have identified the HDAC5 protein as essential for maintenance of telomeres within cancer cells that promote their longevity. Cells with longer telomeres are more resistant to therapies, while cells with shorter telomeres are more susceptible. By targeting this mechanism used to maintain telomeres, existing therapies could become more effective at eradicating cancer.

A new weakness has been discovered in cancer cells that may make them more susceptible to chemotherapy and other treatments. In a research report appearing in the September 2013 issue of The FASEB Journal, scientists identify the HDAC5 protein as being essential for the maintenance of structures, called telomeres, within cancer cells that promote cancer cells longevity. Cancer cells with longer telomeres tend to be more resistant to therapies, while cancer cells with shorter telomeres tend to be more susceptible. By targeting the mechanism used by cancer cells to maintain telomeres, HDAC5, existing therapies could become far more effective at eradicating cancer than they are today.

"Our study can contribute to the development of new combined anti-cancer therapies," said Denis Mottet, Ph.D., a researcher involved in the work from the University of Liege Sart-Tilman, Groupe Interdisciplinaire de Génoprotéomique Appliquée (GIGA)-Cancer, Metastasis Research Laboratory, in Liege, Belgium. "By maintaining a reduced telomere length via HDAC5 inhibition, cancer cells are more sensitive to chemotherapeutic drugs."

To make this discovery, Mottet and colleagues analyzed several cancer cell lines with different backgrounds regarding their telomere biology (different telomere lengths and different molecular mechanisms to maintain telomere length) and found that HDAC5 co-localized with telomeres only in cancer cells with very long telomere lengths. Researchers then depleted this HDAC5 protein in cancer cells with varied telomere lengths and observed a phenotype (shortening of telomeres) exclusively in cancer cells that originally had longer telomeres. Cells with shorter telomeres did not seem to be affected by the absence of the HDAC5 protein. They also found that some cancer cells with very long telomeres were resistant to death induced by common chemotherapy drugs, but the reduction of HDAC5 protein levels in these cells and the subsequent telomere shortening sensitized the cells to these agents, leading to massive cell death. Telomere shortening also is directly linked to cell aging, the development of premature aging syndromes, and advanced aging diseases, this research could eventually have widespread clinical impact.

"The 'cure for cancer' may not come from a single discovery, but will surely arrive step-by-step. This study defines one of those steps." said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal. "What these scientists have done is to accelerate the aging of cancer cells, so as to weaken them enough to be killed by anti-cancer drugs. This type of discovery was unfathomable when Nixon first declared war on the disease in 1971."


Story Source:

The above story is based on materials provided by Federation of American Societies for Experimental Biology. Note: Materials may be edited for content and length.


Journal Reference:

  1. C. L. Novo, C. Polese, N. Matheus, A. Decottignies, A. Londono-Vallejo, V. Castronovo, D. Mottet. A new role for histone deacetylase 5 in the maintenance of long telomeres. The FASEB Journal, 2013; 27 (9): 3632 DOI: 10.1096/fj.12-224204

Cite This Page:

Federation of American Societies for Experimental Biology. "Newly discovered weakness in cancer cells make them more susceptible to chemotherapy." ScienceDaily. ScienceDaily, 29 August 2013. <www.sciencedaily.com/releases/2013/08/130829110415.htm>.
Federation of American Societies for Experimental Biology. (2013, August 29). Newly discovered weakness in cancer cells make them more susceptible to chemotherapy. ScienceDaily. Retrieved August 28, 2014 from www.sciencedaily.com/releases/2013/08/130829110415.htm
Federation of American Societies for Experimental Biology. "Newly discovered weakness in cancer cells make them more susceptible to chemotherapy." ScienceDaily. www.sciencedaily.com/releases/2013/08/130829110415.htm (accessed August 28, 2014).

Share This




More Health & Medicine News

Thursday, August 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Mini Pacemaker Has No Wires

Mini Pacemaker Has No Wires

Ivanhoe (Aug. 27, 2014) — Cardiac experts are testing a new experimental device designed to eliminate major surgery and still keep the heart on track. Video provided by Ivanhoe
Powered by NewsLook.com
After Cancer: Rebuilding Breasts With Fat

After Cancer: Rebuilding Breasts With Fat

Ivanhoe (Aug. 27, 2014) — More than 269 million women are diagnosed with breast cancer each year. Many of them will need surgery and radiation, but there’s a new simple way to reconstruct tissue using a patient’s own fat. Video provided by Ivanhoe
Powered by NewsLook.com
Blood Clots in Kids

Blood Clots in Kids

Ivanhoe (Aug. 27, 2014) — Every year, up to 200,000 Americans die from a blood clot that travels to their lungs. You’ve heard about clots in adults, but new research shows kids can get them too. Video provided by Ivanhoe
Powered by NewsLook.com
Radio Waves Knock out Knee Pain

Radio Waves Knock out Knee Pain

Ivanhoe (Aug. 27, 2014) — Doctors have used radio frequency ablation or RFA to reduce neck and back pain for years. But now, that same technique is providing longer-term relief for patients with severe knee pain. Video provided by Ivanhoe
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins