Featured Research

from universities, journals, and other organizations

Two tests in combination can provide better asthma diagnosis

Date:
September 24, 2013
Source:
Uppsala Universitet
Summary:
It was previously thought that two main test methods signalled the same type of asthma. But a new study shows that the methods actually signal two different inflammatory processes. With the tests used in combination, the chances are probably greater for the patient to receive just the right treatment.

It was previously thought that the two test methods signalled the same type of asthma. But a new study, led by researchers at Uppsala University, Sweden, shows that the methods actually signal two different inflammatory processes. With the tests used in combination, the chances are probably greater for the patient to receive just the right treatment. The study is being published in the October issue of Journal of Allergy and Clinical Immunology.

Measurement of the concentration of exhaled nitric oxide (FeNO) is today a routine clinical method for determining the degree of steroid-sensitive inflammation in the airways in asthma. For many years a count of eosinophil granulocytes in the blood has also been used to support a diagnosis of asthma.

These two methods were previously thought to signal the same inflammation process in asthma. In the new study, researchers investigated the importance of these two clinically used inflammation markers with the help of information from a large American population-based database (National Health and Nutrition Examination Survey) where 12,408 individuals aged 6-80 were included.

The scientists were able to determine that the association between FeNO and blood eosinophils was very weak. Instead, they observed that simultaneously elevated levels of the two markers, in a synergistic way, but independently of each other, increased the likelihood of individuals reporting, for example, asthma symptoms or asthma attacks in the last year.

The results supported the researchers' hypothesis that the two markers represent two different inflammation processes.

- We therefore propose that both of these measurements be carried out in combination in order to better understand the inflammation in asthma patients. They thus constitute a better platform for selecting the proper treatment for these patients, says Kjell Alving, professor at the Department of Children's and Women's Health, Uppsala University.


Story Source:

The above story is based on materials provided by Uppsala Universitet. Note: Materials may be edited for content and length.


Journal Reference:

  1. Andrei Malinovschi, João A. Fonseca, Tiago Jacinto, Kjell Alving, Christer Janson. Exhaled nitric oxide levels and blood eosinophil counts independently associate with wheeze and asthma events in National Health and Nutrition Examination Survey subjects. Journal of Allergy and Clinical Immunology, 2013; DOI: 10.1016/j.jaci.2013.06.007

Cite This Page:

Uppsala Universitet. "Two tests in combination can provide better asthma diagnosis." ScienceDaily. ScienceDaily, 24 September 2013. <www.sciencedaily.com/releases/2013/09/130924091524.htm>.
Uppsala Universitet. (2013, September 24). Two tests in combination can provide better asthma diagnosis. ScienceDaily. Retrieved September 23, 2014 from www.sciencedaily.com/releases/2013/09/130924091524.htm
Uppsala Universitet. "Two tests in combination can provide better asthma diagnosis." ScienceDaily. www.sciencedaily.com/releases/2013/09/130924091524.htm (accessed September 23, 2014).

Share This



More Health & Medicine News

Tuesday, September 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Liberia Pleads for Help to Fight Ebola

Liberia Pleads for Help to Fight Ebola

AP (Sep. 22, 2014) — Liberia's finance minister is urging the international community to quickly follow through on pledges of cash to battle Ebola. Bodies are piling up in the capital Monrovia as the nation awaits more help. (Sept. 22) Video provided by AP
Powered by NewsLook.com
Ebola Doctor Says Border Controls Critical

Ebola Doctor Says Border Controls Critical

AP (Sep. 22, 2014) — A Florida doctor who helped fight the expanding Ebola outbreak in West Africa says the disease can be stopped, but only if nations quickly step up their response and make border control a priority. (Sept. 22) Video provided by AP
Powered by NewsLook.com
Global Ebola Aid Increasing But Critics Say It's Late

Global Ebola Aid Increasing But Critics Say It's Late

Newsy (Sep. 21, 2014) — More than 100 tons of medical supplies were sent to West Africa on Saturday, but aid workers say the global response is still sluggish. Video provided by Newsy
Powered by NewsLook.com
Sierra Leone in Lockdown to Control Ebola

Sierra Leone in Lockdown to Control Ebola

AP (Sep. 21, 2014) — Sierra Leone residents remained in lockdown on Saturday as part of a massive effort to confine millions of people to their homes in a bid to stem the biggest Ebola outbreak in history. (Sept. 20) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins