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Uncovering factors at the heart of muscle weakness

Date:
September 25, 2013
Source:
Organization of Frontier Science and Innovation, Kanazawa University
Summary:
Researchers show how orange, apple and grapefruit juices affect the absorption of certain prescription drugs into the body.

Prof. Tamai's latest research examines how orange, apple and grapefruit juices affect the absorption of prescription drugs into the body.
Credit: Elenathewise / Fotolia

Prof. Tamai of Kanazawa University has been examining how orange, apple and grapefruit juices affect the absorption of certain prescription drugs into the body.

Ikumi Tamai, has dedicated his career to investigating the molecules and genes responsible for cardiomyopathy, muscle weakness, and Reye's syndrome. His key discoveries relate to human organic anion transporting polypeptides (OATPs), their associated genes and their roles in the body.

Muscle weakening diseases are known to be triggered by a deficiency of carnitine in the body -- a compound that helps to transport fatty acids for the generation of metabolic energy after the breakdown of lipids. Little was known about the mechanisms inherent in carnitine deficiency until Tamai's work in the late 1990s led to the discovery of carnitine transporter OCTN2.

OCTN2 is expressed strongly in the kidneys, skeletal muscle, and the heart. If OCTN2 expression is disrupted, the defective transport of carnitine across plasma membranes increases the chances of muscle weakness.

In 1999, Tamai uncovered the gene responsible for encoding OCTN2 -- SLC22A5 -- and showed that patients with mutations in SLC22A5 exhibit carnitine transportation deficiencies. This discovery helped "contribute to a better understanding of the molecular mechanism of systemic carnitine deficiency and normal lipid metabolism... allow[ing] genetic screening and gene therapy [for] families with disease history."

Following on from these successes, Tamai went on to categorize all OATPs present in the human body, including three novel polypeptides. In his most recent research, Tamai is investigating OATPs and their influence on drug absorption in the body. His newest papers examine the intake of fruit juices and their effects on the absorption of prescription drugs into the body. In particular, Tamai is focusing how sugars such as naringin and hesperidin in orange, apple and grapefruit juices affect how drugs are absorbed.


Story Source:

The above story is based on materials provided by Organization of Frontier Science and Innovation, Kanazawa University. Note: Materials may be edited for content and length.


Journal References:

  1. Yoshiyuki Shirasaka, Megumi Shichiri, Takanori Mori, Takeo Nakanishi, Ikumi Tamai. Major active components in grapefruit, orange, and apple juices responsible for OATP2B1-mediated drug interactions. Journal of Pharmaceutical Sciences, 2013; 102 (1): 280 DOI: 10.1002/jps.23357
  2. Y. Shirasaka, M. Shichiri, Y. Murata, T. Mori, T. Nakanishi, I. Tamai. Long-Lasting Inhibitory Effect of Apple and Orange Juices, but Not Grapefruit Juice, on OATP2B1-Mediated Drug Absorption. Drug Metabolism and Disposition, 2012; 41 (3): 615 DOI: 10.1124/dmd.112.049635

Cite This Page:

Organization of Frontier Science and Innovation, Kanazawa University. "Uncovering factors at the heart of muscle weakness." ScienceDaily. ScienceDaily, 25 September 2013. <www.sciencedaily.com/releases/2013/09/130925112228.htm>.
Organization of Frontier Science and Innovation, Kanazawa University. (2013, September 25). Uncovering factors at the heart of muscle weakness. ScienceDaily. Retrieved August 27, 2014 from www.sciencedaily.com/releases/2013/09/130925112228.htm
Organization of Frontier Science and Innovation, Kanazawa University. "Uncovering factors at the heart of muscle weakness." ScienceDaily. www.sciencedaily.com/releases/2013/09/130925112228.htm (accessed August 27, 2014).

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