Featured Research

from universities, journals, and other organizations

Baculovirus-recognising human cell receptor identified for the first time

Date:
September 27, 2013
Source:
Suomen Akatemia (Academy of Finland)
Summary:
The receptor used by baculovirus to enter and interact with human cells has been identified for the first time.

The receptor used by baculovirus to enter and interact with human cells has been identified. This syndecan–1 receptor was identified for the first time in a recent collaborative study carried out by the University of Eastern Finland and the University of Jyväskylä in Finland. The findings increase our understanding of the strategies by which the virus causes infection in cells and further facilitates the development of baculovirus for applications of gene transfer. According to the researchers, the identification of the syndecan–1 receptor helps in understanding the ways baculovirus interacts with human cells and sheds further light on the mechanisms the virus uses in human cells.

The study also focused on the role of the syndecan–1 receptor in the cell penetration of baculovirus.

The study was published in the prestigious Journal of Virology.

Used in drugs and vaccines

Baculovirus is an insect-infecting virus, which is largely utilised in biotechnology applications. Baculoviruses are used, for example, in the manufacturing of Glyberan, the first gene therapy of the Western world, and in the manufacturing of the cancer vaccines Cervarix and Provenge, and the influenza vaccine Flublok. The technology is approved by the U.S. Food and Drug Administration, FDA, and the European Medicines Agency, EMA.

Baculovirus is not harmful to human cells, and this is why baculoviruses have become subjects of intensive research also with regard to gene therapy. In gene therapy, DNA to correct genetic errors is transported into cells using a variety of methods. Earlier studies have not been able to identify the receptor that recognises the virus, despite the fact that baculovirus has been studied intensively for decades.

The doctoral dissertation of Ms Paula Turkki, MA, on the topic in the field of cell and molecular biology will be publicly examined at the Department of Biological and Environmental Science of the University of Jyväskylä on 25 October 2013.


Story Source:

The above story is based on materials provided by Suomen Akatemia (Academy of Finland). Note: Materials may be edited for content and length.


Journal Reference:

  1. K.-E. Makkonen, P. Turkki, J. P. Laakkonen, S. Yla-Herttuala, V. Marjomaki, K. J. Airenne. 6-O- and N-Sulfated Syndecan-1 Promotes Baculovirus Binding and Entry into Mammalian Cells. Journal of Virology, 2013; 87 (20): 11148 DOI: 10.1128/JVI.01919-13

Cite This Page:

Suomen Akatemia (Academy of Finland). "Baculovirus-recognising human cell receptor identified for the first time." ScienceDaily. ScienceDaily, 27 September 2013. <www.sciencedaily.com/releases/2013/09/130927092354.htm>.
Suomen Akatemia (Academy of Finland). (2013, September 27). Baculovirus-recognising human cell receptor identified for the first time. ScienceDaily. Retrieved September 17, 2014 from www.sciencedaily.com/releases/2013/09/130927092354.htm
Suomen Akatemia (Academy of Finland). "Baculovirus-recognising human cell receptor identified for the first time." ScienceDaily. www.sciencedaily.com/releases/2013/09/130927092354.htm (accessed September 17, 2014).

Share This



More Health & Medicine News

Wednesday, September 17, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

President To Send 3,000 Military Personnel To Fight Ebola

President To Send 3,000 Military Personnel To Fight Ebola

Newsy (Sep. 16, 2014) — President Obama is expected to send 3,000 troops to West Africa as part of the effort to contain Ebola's spread. Video provided by Newsy
Powered by NewsLook.com
Man Floats for 31 Hours in Gulf Waters

Man Floats for 31 Hours in Gulf Waters

AP (Sep. 16, 2014) — A Texas man is lucky to be alive after he and three others floated for more than a day in the Gulf of Mexico when their boat sank during a fishing trip. (Sept. 16) Video provided by AP
Powered by NewsLook.com
Ivorians Abandon Monkey Pets in Fear Over Ebola Virus

Ivorians Abandon Monkey Pets in Fear Over Ebola Virus

AFP (Sep. 16, 2014) — Since the arrival of Ebola in Ivory Coast, Ivorians have been abandoning their pets, particularly monkeys, in the fear that they may transmit the virus. Duration: 00:47 Video provided by AFP
Powered by NewsLook.com
Study Links Male-Pattern Baldness To Prostate Cancer

Study Links Male-Pattern Baldness To Prostate Cancer

Newsy (Sep. 16, 2014) — New findings suggest men with a certain type of baldness at age 45 are 39 percent more likely to develop aggressive prostate cancer. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

      Technology News



      Save/Print:
      Share:  

      Free Subscriptions


      Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

      Get Social & Mobile


      Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

      Have Feedback?


      Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
      Mobile iPhone Android Web
      Follow Facebook Twitter Google+
      Subscribe RSS Feeds Email Newsletters
      Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins