Featured Research

from universities, journals, and other organizations

Baculovirus-recognising human cell receptor identified for the first time

Date:
September 27, 2013
Source:
Suomen Akatemia (Academy of Finland)
Summary:
The receptor used by baculovirus to enter and interact with human cells has been identified for the first time.

The receptor used by baculovirus to enter and interact with human cells has been identified. This syndecan–1 receptor was identified for the first time in a recent collaborative study carried out by the University of Eastern Finland and the University of Jyväskylä in Finland. The findings increase our understanding of the strategies by which the virus causes infection in cells and further facilitates the development of baculovirus for applications of gene transfer. According to the researchers, the identification of the syndecan–1 receptor helps in understanding the ways baculovirus interacts with human cells and sheds further light on the mechanisms the virus uses in human cells.

The study also focused on the role of the syndecan–1 receptor in the cell penetration of baculovirus.

The study was published in the prestigious Journal of Virology.

Used in drugs and vaccines

Baculovirus is an insect-infecting virus, which is largely utilised in biotechnology applications. Baculoviruses are used, for example, in the manufacturing of Glyberan, the first gene therapy of the Western world, and in the manufacturing of the cancer vaccines Cervarix and Provenge, and the influenza vaccine Flublok. The technology is approved by the U.S. Food and Drug Administration, FDA, and the European Medicines Agency, EMA.

Baculovirus is not harmful to human cells, and this is why baculoviruses have become subjects of intensive research also with regard to gene therapy. In gene therapy, DNA to correct genetic errors is transported into cells using a variety of methods. Earlier studies have not been able to identify the receptor that recognises the virus, despite the fact that baculovirus has been studied intensively for decades.

The doctoral dissertation of Ms Paula Turkki, MA, on the topic in the field of cell and molecular biology will be publicly examined at the Department of Biological and Environmental Science of the University of Jyväskylä on 25 October 2013.


Story Source:

The above story is based on materials provided by Suomen Akatemia (Academy of Finland). Note: Materials may be edited for content and length.


Journal Reference:

  1. K.-E. Makkonen, P. Turkki, J. P. Laakkonen, S. Yla-Herttuala, V. Marjomaki, K. J. Airenne. 6-O- and N-Sulfated Syndecan-1 Promotes Baculovirus Binding and Entry into Mammalian Cells. Journal of Virology, 2013; 87 (20): 11148 DOI: 10.1128/JVI.01919-13

Cite This Page:

Suomen Akatemia (Academy of Finland). "Baculovirus-recognising human cell receptor identified for the first time." ScienceDaily. ScienceDaily, 27 September 2013. <www.sciencedaily.com/releases/2013/09/130927092354.htm>.
Suomen Akatemia (Academy of Finland). (2013, September 27). Baculovirus-recognising human cell receptor identified for the first time. ScienceDaily. Retrieved July 23, 2014 from www.sciencedaily.com/releases/2013/09/130927092354.htm
Suomen Akatemia (Academy of Finland). "Baculovirus-recognising human cell receptor identified for the first time." ScienceDaily. www.sciencedaily.com/releases/2013/09/130927092354.htm (accessed July 23, 2014).

Share This




More Health & Medicine News

Wednesday, July 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Courts Conflicted Over Healthcare Law

Courts Conflicted Over Healthcare Law

AP (July 22, 2014) — Two federal appeals courts issued conflicting rulings Tuesday on the legality of the federally-run healthcare exchange that operates in 36 states. (July 22) Video provided by AP
Powered by NewsLook.com
Why Do People Believe We Only Use 10 Percent Of Our Brains?

Why Do People Believe We Only Use 10 Percent Of Our Brains?

Newsy (July 22, 2014) — The new sci-fi thriller "Lucy" is making people question whether we really use all our brainpower. But, as scientists have insisted for years, we do. Video provided by Newsy
Powered by NewsLook.com
Scientists Find New Way To Make Human Platelets

Scientists Find New Way To Make Human Platelets

Newsy (July 22, 2014) — Boston scientists have discovered a new way to create fully functioning human platelets using a bioreactor and human stem cells. Video provided by Newsy
Powered by NewsLook.com
Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

TheStreet (July 21, 2014) — New research shows Gilead Science's drug Sovaldi helps in curing hepatitis C in those who suffer from HIV. In a medical study, the combination of Gilead's Hep C drug with anti-viral drug Ribavirin cured 76% of HIV-positive patients suffering from the most common hepatitis C strain. Hepatitis C and related complications have been a top cause of death in HIV-positive patients. Typical medication used to treat the disease, including interferon proteins, tended to react badly with HIV drugs. However, Sovaldi's %1,000-a-pill price tag could limit the number of patients able to access the treatment. TheStreet's Keris Lahiff reports from New York. Video provided by TheStreet
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins