Featured Research

from universities, journals, and other organizations

Statin therapy before coronary artery bypass grafting may improve outcomes

Date:
October 1, 2013
Source:
Society of Thoracic Surgeons
Summary:
Patients receiving statin therapy before coronary artery bypass grafting (CABG) surgery appear to have a reduced risk of post-surgical mortality, stroke, and atrial fibrillation (irregular or rapid heart rate).

Patients receiving statin therapy before coronary artery bypass grafting (CABG) surgery appear to have a reduced risk of post-surgical mortality, stroke, and atrial fibrillation (irregular or rapid heart rate), according to an article in the October 2013 issue of The Annals of Thoracic Surgery. These same benefits from statins could not be demonstrated for patients undergoing aortic valve replacement (AVR).

"Heart surgery patients typically have a number of other disorders, so we need to optimize the patient's preoperative condition and help ensure the best possible result," said Elmar W. Kuhn, MD, from the University of Cologne in Germany.

Statins are commonly used to lower levels of low-density lipoprotein (LDL), also known as "bad" cholesterol, which helps reduce the risk of cardiovascular disease in those at high risk.

Previous research has shown that statin therapy is beneficial for bypass patients in some trials, but other studies failed to confirm this effect. Dr. Kuhn, Oliver J. Liakopoulos, MD, and colleagues analyzed current research to see if preoperative statin therapy improved results for isolated CABG and AVR operations.

The analysis included 36 studies, 32 of which assessed statin treatment before CABG surgery with a total of 36,053 patients, and four that analyzed statin effects in a total of 3,091 patients undergoing AVR surgery.

Overall, the mortality rate among patients taking statins before CABG surgery was lower than the mortality rate among patients not taking statins, and a 19% reduction in the risk of stroke was found among patients taking statins compared to the control group. No significant reduction was found in the risk of heart attack or atrial fibrillation.

For AVR, statin therapy before surgery produced no significant differences in any of these post-surgical outcomes.

"Our result underlines the importance of statin therapy before CABG procedures," said Dr. Liakopoulos. "We therefore hope that more patients are treated with statins prior to bypass surgery, but recognize that our work may not impact the current care for patients undergoing aortic valve replacement. In general, we believe these results can prompt greater efforts to improve preoperative management."

The American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines recommends statin treatment for all patients undergoing CABG surgery, regardless of their LDL levels before surgery.


Story Source:

The above story is based on materials provided by Society of Thoracic Surgeons. Note: Materials may be edited for content and length.


Journal Reference:

  1. Elmar W. Kuhn, Oliver J. Liakopoulos, Sebastian Stange, Antje-Christin Deppe, Ingo Slottosch, Maximilian Scherner, Yeong-Hoon Choi, Thorsten Wahlers. Meta-Analysis of Patients Taking Statins Before Revascularization and Aortic Valve Surgery. The Annals of Thoracic Surgery, 2013; 96 (4): 1508 DOI: 10.1016/j.athoracsur.2013.04.096

Cite This Page:

Society of Thoracic Surgeons. "Statin therapy before coronary artery bypass grafting may improve outcomes." ScienceDaily. ScienceDaily, 1 October 2013. <www.sciencedaily.com/releases/2013/10/131001090006.htm>.
Society of Thoracic Surgeons. (2013, October 1). Statin therapy before coronary artery bypass grafting may improve outcomes. ScienceDaily. Retrieved October 22, 2014 from www.sciencedaily.com/releases/2013/10/131001090006.htm
Society of Thoracic Surgeons. "Statin therapy before coronary artery bypass grafting may improve outcomes." ScienceDaily. www.sciencedaily.com/releases/2013/10/131001090006.htm (accessed October 22, 2014).

Share This



More Health & Medicine News

Wednesday, October 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Working Mother (Oct. 22, 2014) Is your child ready? Video provided by Working Mother
Powered by NewsLook.com
U.S. Issues Ebola Travel Restrictions, Are Visa Bans Next?

U.S. Issues Ebola Travel Restrictions, Are Visa Bans Next?

Newsy (Oct. 22, 2014) Now that the U.S. is restricting travel from West Africa, some are dropping questions about a travel ban and instead asking about visa bans. Video provided by Newsy
Powered by NewsLook.com
CDC Revamps Ebola Guidelines After Criticism

CDC Revamps Ebola Guidelines After Criticism

Newsy (Oct. 21, 2014) The Centers for Disease Control and Prevention have issued new protocols for healthcare workers interacting with Ebola patients. Video provided by Newsy
Powered by NewsLook.com
WHO: Ebola Vaccine Trials to Start a in January

WHO: Ebola Vaccine Trials to Start a in January

AP (Oct. 21, 2014) Tens of thousands of doses of experimental Ebola vaccines could be available for "real-world" testing in West Africa as soon as January as long as they are deemed safe in soon to start trials, the World Health Organization said Tuesday. (Oct. 21) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins