Featured Research

from universities, journals, and other organizations

Likely culprit behind liver problems linked to intravenous feeding

Date:
October 9, 2013
Source:
University of Colorado Denver
Summary:
Researchers know that feeding some patients intravenously can save their lives -- but also can cause liver damage. Now scientists have figured out the likely culprit, one of the ingredients in intravenous food, behind the liver problems.

Researchers know that feeding some patients intravenously can save their lives -- but also can cause liver damage. Now scientists at the University of Colorado and Children's Hospital Colorado have figured out the likely culprit, one of the ingredients in intravenous food, behind the liver problems.

The discovery, published Oct. 9 in Science Translational Medicine, could point the way to better treatments for patients who are medically vulnerable and, often, very young.

"We still have more to learn about the optimal mix of lipids for intravenous nutrition," said Ron Sokol, part of the research team. "Our hope is that this study will lead us to intravenous nutrition that results in less stress on the liver."

A life-saving option for some patients with intestinal problems or pancreatitis is to provide food intravenously. But this option, usually used for patients who can't tolerate or absorb food from their intestines, is associated with liver damage while helping in other ways.

The risk is especially high for premature infants and children with intestinal failure or short bowel syndrome, who often depend on intravenous feeding -- or Parenteral nutrition (PN) -- for years. The longer a patient is on PN and the more severe their intestinal problems, the greater the risk of what is called PN-associated liver disease (PNALD).

Clinical evidence had suggested that lipids derived from soy might be part of the problem. The researchers, also representing University of Cincinnati, Cincinnati Children's Hospital and Emory University, zeroed in on the soy factor.

They found that one derivative of soy -- called stigmasterol -- appeared to prevent the flow of bile from the liver in experimental mice. They also figured out the chemical mechanism behind that problem, and found that microbes in the gut appeared to contribute to PNALD as well.

"The results of this study may help promote a shift away from solutions containing stigmasterol for patients dependent on intravenous nutrition," Sokol said.


Story Source:

The above story is based on materials provided by University of Colorado Denver. Note: Materials may be edited for content and length.


Journal Reference:

  1. K. C. El Kasmi, A. L. Anderson, M. W. Devereaux, P. M. Vue, W. Zhang, K. D. R. Setchell, S. J. Karpen, R. J. Sokol. Phytosterols Promote Liver Injury and Kupffer Cell Activation in Parenteral Nutrition-Associated Liver Disease. Science Translational Medicine, 2013; 5 (206): 206ra137 DOI: 10.1126/scitranslmed.3006898

Cite This Page:

University of Colorado Denver. "Likely culprit behind liver problems linked to intravenous feeding." ScienceDaily. ScienceDaily, 9 October 2013. <www.sciencedaily.com/releases/2013/10/131009162728.htm>.
University of Colorado Denver. (2013, October 9). Likely culprit behind liver problems linked to intravenous feeding. ScienceDaily. Retrieved July 30, 2014 from www.sciencedaily.com/releases/2013/10/131009162728.htm
University of Colorado Denver. "Likely culprit behind liver problems linked to intravenous feeding." ScienceDaily. www.sciencedaily.com/releases/2013/10/131009162728.htm (accessed July 30, 2014).

Share This




More Health & Medicine News

Wednesday, July 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Generics Eat Into Pfizer's Sales

Generics Eat Into Pfizer's Sales

Reuters - Business Video Online (July 29, 2014) Pfizer, the world's largest drug maker, cut full-year revenue forecasts because generics could cut into sales of its anti-arthritis drug, Celebrex. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
Nigeria Ups Ebola Stakes on 1st Death

Nigeria Ups Ebola Stakes on 1st Death

Reuters - Business Video Online (July 29, 2014) Nigerian authorities have shut and quarantined a Lagos hospital where a Liberian man died of the Ebola virus, the first recorded case of the highly-infectious disease in Africa's most populous economy. David Pollard reports Video provided by Reuters
Powered by NewsLook.com
Running 5 Minutes A Day Might Add Years To Your Life

Running 5 Minutes A Day Might Add Years To Your Life

Newsy (July 29, 2014) According to a new study, just five minutes of running or jogging a day could add years to your life. Video provided by Newsy
Powered by NewsLook.com
Ebola Outbreak Poses Little Threat To U.S.: CDC

Ebola Outbreak Poses Little Threat To U.S.: CDC

Newsy (July 29, 2014) The Ebola outbreak in West Africa poses little threat to Americans, according to officials with the Centers for Disease Control and Prevention. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins