Featured Research

from universities, journals, and other organizations

Immune system discovery could lead to vaccine to prevent mono, some cancers

Date:
October 12, 2013
Source:
Child & Family Research Institute
Summary:
Development of a vaccine against Epstein-Barr virus (EBV) has taken a step forward with the Canadian discovery of how EBV infection evades detection by the immune system.

Development of a vaccine against Epstein-Barr virus (EBV) has taken a step forward with the Canadian discovery of how EBV infection evades detection by the immune system.

EBV causes infectious mononucleosis and cancers such as Hodgkin's lymphoma and nasopharyngeal carcinoma, which is the most common cancer in China, as well as opportunistic cancers in people with weakened immune systems. A member of the herpes virus family that remains in the body for life, the virus infects epithelial cells in the throat and immune cells called B cells.

The researchers discovered that the virus triggers molecular events that turn off key proteins, making infected cells invisible to the natural killer T (NKT) immune cells that seek and destroy EBV-infected cells.

"If you can force these invisible proteins to be expressed, then you can render infected cells visible to NKT cells, and defeat the virus. This could be key to making a vaccine that would provide immunity from ever being infected with EBV," says Dr. Rusung Tan, the study's principal investigator. Dr. Tan is a scientist and director of the Immunity in Health & Disease research group at the Child & Family Research Institute at BC Children's Hospital, and a professor in the Department of Pathology at the University of British Columbia.

The findings were published this week in the print edition of the scientific journal Blood.

For this study, the researchers looked at cells from infected tonsils that had been removed from patients at BC Children's Hospital by Dr. Frederick Kozak. The researchers infected the tonsillar B cells with EBV, and then combined some of these cells with NKT cells. They found that more NKT cells led to fewer EBV-infected cells, while an absence of NKT cells was associated with an increase in EBV-infected cells.


Story Source:

The above story is based on materials provided by Child & Family Research Institute. Note: Materials may be edited for content and length.


Journal Reference:

  1. B. K. Chung, K. Tsai, L. L. Allan, D. J. Zheng, J. C. Nie, C. M. Biggs, M. R. Hasan, F. K. Kozak, P. van den Elzen, J. J. Priatel, R. Tan. Innate immune control of EBV-infected B cells by invariant natural killer T cells. Blood, 2013; 122 (15): 2600 DOI: 10.1182/blood-2013-01-480665

Cite This Page:

Child & Family Research Institute. "Immune system discovery could lead to vaccine to prevent mono, some cancers." ScienceDaily. ScienceDaily, 12 October 2013. <www.sciencedaily.com/releases/2013/10/131012093040.htm>.
Child & Family Research Institute. (2013, October 12). Immune system discovery could lead to vaccine to prevent mono, some cancers. ScienceDaily. Retrieved April 19, 2014 from www.sciencedaily.com/releases/2013/10/131012093040.htm
Child & Family Research Institute. "Immune system discovery could lead to vaccine to prevent mono, some cancers." ScienceDaily. www.sciencedaily.com/releases/2013/10/131012093040.htm (accessed April 19, 2014).

Share This



More Health & Medicine News

Saturday, April 19, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Nine-Month-Old Baby Can't Open His Mouth

Nine-Month-Old Baby Can't Open His Mouth

Newsy (Apr. 19, 2014) Nine-month-old Wyatt Scott was born with a rare disorder called congenital trismus, which prevents him from opening his mouth. Video provided by Newsy
Powered by NewsLook.com
'Holy Grail' Of Weight Loss? New Find Could Be It

'Holy Grail' Of Weight Loss? New Find Could Be It

Newsy (Apr. 18, 2014) In a potential breakthrough for future obesity treatments, scientists have used MRI scans to pinpoint brown fat in a living adult for the first time. Video provided by Newsy
Powered by NewsLook.com
Little Progress Made In Fighting Food Poisoning, CDC Says

Little Progress Made In Fighting Food Poisoning, CDC Says

Newsy (Apr. 18, 2014) A new report shows rates of two foodborne infections increased in the U.S. in recent years, while salmonella actually dropped 9 percent. Video provided by Newsy
Powered by NewsLook.com
Scientists Create Stem Cells From Adult Skin Cells

Scientists Create Stem Cells From Adult Skin Cells

Newsy (Apr. 17, 2014) The breakthrough could mean a cure for some serious diseases and even the possibility of human cloning, but it's all still a way off. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins