Featured Research

from universities, journals, and other organizations

Soldiers with certain gene variations more likely to develop chronic pain after amputation

Date:
October 14, 2013
Source:
American Society of Anesthesiologists (ASA)
Summary:
Researchers have identified hundreds of variants in a patient’s DNA sequence or genetic code that predict which military service members are more likely to develop persistent, chronic pain after amputation.

Researchers have identified hundreds of variants in a patient's DNA sequence or genetic code that predict which military service members are more likely to develop persistent, chronic pain after amputation, according to a study presented at the ANESTHESIOLOGY™ 2013 annual meeting.

Related Articles


From 2000 to 2011, there were 6,144 amputations among 5,694 injured service members, according to the Armed Forces Health Surveillance Center. More than one-third had major amputations, defined as the loss of a hand, foot or more.

"Traumatic amputations of limbs profoundly change the lives of affected military service members," said Andrew D. Shaw, M.D., associate professor of anesthesiology and critical care medicine, Duke University Medical Center, Durham, N.C. "Persistent pain after amputation is a serious problem with no effective treatments. By identifying these 'pain genes,' we may be able to discover the reasons why pain occurs and predict which patients are more likely to have it. In the future, we hope to discover the biology of persistent pain and develop ways to combat it."

In the study, blood was collected for DNA, RNA and plasma extraction from 49 service members who had amputations and persistent pain. These blood samples were then mapped using Exome Sequencing technology to identify any variations the military service members have in common.

Hundreds of new DNA sequence variations previously unknown were identified as pathways of biological importance as the possible source of chronic, persistent pain for service members, according to the study.

"This is one of the first studies where 'pain genes' have been identified in humans using next-generation sequencing," explained Dr. Shaw. "We have known about some of them in lab studies. Now that we have identified these gene variations, we need to study them and then create new medicines to prevent and relieve the chronic pain for these patients."


Story Source:

The above story is based on materials provided by American Society of Anesthesiologists (ASA). Note: Materials may be edited for content and length.


Cite This Page:

American Society of Anesthesiologists (ASA). "Soldiers with certain gene variations more likely to develop chronic pain after amputation." ScienceDaily. ScienceDaily, 14 October 2013. <www.sciencedaily.com/releases/2013/10/131014113734.htm>.
American Society of Anesthesiologists (ASA). (2013, October 14). Soldiers with certain gene variations more likely to develop chronic pain after amputation. ScienceDaily. Retrieved November 24, 2014 from www.sciencedaily.com/releases/2013/10/131014113734.htm
American Society of Anesthesiologists (ASA). "Soldiers with certain gene variations more likely to develop chronic pain after amputation." ScienceDaily. www.sciencedaily.com/releases/2013/10/131014113734.htm (accessed November 24, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, November 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola-Hit Sierra Leone's Late Cocoa Leaves Bitter Taste

Ebola-Hit Sierra Leone's Late Cocoa Leaves Bitter Taste

AFP (Nov. 23, 2014) The arable district of Kenema in Sierra Leone -- at the centre of the Ebola outbreak in May -- has been under quarantine for three months as the cocoa harvest comes in. Duration: 01:32 Video provided by AFP
Powered by NewsLook.com
Don't Fall For Flu Shot Myths

Don't Fall For Flu Shot Myths

Newsy (Nov. 23, 2014) Misconceptions abound when it comes to your annual flu shot. Medical experts say most people older than 6 months should get the shot. Video provided by Newsy
Powered by NewsLook.com
WFP: Ebola Risks Heightened Among Women Throughout Africa

WFP: Ebola Risks Heightened Among Women Throughout Africa

AFP (Nov. 21, 2014) Having children has always been a frightening prospect in Sierra Leone, the world's most dangerous place to give birth, but Ebola has presented an alarming new threat for expectant mothers. Duration: 00:37 Video provided by AFP
Powered by NewsLook.com
Could Your Genes Be The Reason You're Single?

Could Your Genes Be The Reason You're Single?

Newsy (Nov. 21, 2014) Researchers in Beijing discovered a gene called 5-HTA1, and carriers are reportedly 20 percent more likely to be single. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins