Featured Research

from universities, journals, and other organizations

New blood test could help millions with gastrointestinal disorders

Date:
October 16, 2013
Source:
Cedars-Sinai Medical Center
Summary:
For the first time, a simple blood test may be the best way to determine if a patient is suffering from Irritable Bowel Syndrome (IBS), or another serious condition such as Inflammatory Bowel Disease (IBD,).

For the first time, a simple blood test may be the best way to determine if a patient is suffering from Irritable Bowel Syndrome (IBS), or another serious condition such as Inflammatory Bowel Disease (IBD,) according to Cedars-Sinai physician researcher Mark Pimentel, MD, lead author of a multicenter clinical trial.

Related Articles


Researchers conclusively identified a test for antibodies that form against a particular protein, vinculin, found in the guts of patients, many of whom suffered acute gastroenteritis at some point.

"This is a major breakthrough. It is the first test with a high specificity for IBS, likely based on a pathological mechanism of the disease," said Pimentel, the director of the Cedars-Sinai GI Motility Program and the GI Motility Laboratory. Pimentel is co-author of the study and results were presented for the first time this week at the American College of Gastroenterology's 78th Annual Scientific Meeting in San Diego, Calif.

In the study, 221 patients were evaluated; some had a diagnosis of IBS, some were diagnosed with IBD and some were healthy, with no symptoms. Anti-vinculin antibodies were significantly elevated in IBS patients as compared to those with IBD or those who were healthy.

"Until this study, there had been no accurate biomarkers identified specifically for IBS. The new blood test has the potential to distinguish IBS from IBD and reduce the need for unnecessary testing, expense and years of suffering," says Pimentel.

Irritable Bowel Syndrome is the most common gastrointestinal disorder in the U.S., afflicting 30 million people. Food poisoning has been identified as a significant risk factor for developing the disorder which is characterized by a cluster of symptoms including diarrhea, bloating and abdominal pain. But millions of patients are never diagnosed correctly. A simple blood test at the first sign of symptoms means patients who have IBS could get effective treatment sooner.

More than a decade ago, Pimentel went up against the conventional medical understanding of IBS when his research suggested the overgrowth of bacteria in the gut was a contributing cause of the condition. Today, antibiotics play a key therapeutic role in bringing relief to millions of patients. A definitive blood test for IBS would represent a significant new development.


Story Source:

The above story is based on materials provided by Cedars-Sinai Medical Center. Note: Materials may be edited for content and length.


Cite This Page:

Cedars-Sinai Medical Center. "New blood test could help millions with gastrointestinal disorders." ScienceDaily. ScienceDaily, 16 October 2013. <www.sciencedaily.com/releases/2013/10/131016095939.htm>.
Cedars-Sinai Medical Center. (2013, October 16). New blood test could help millions with gastrointestinal disorders. ScienceDaily. Retrieved January 31, 2015 from www.sciencedaily.com/releases/2013/10/131016095939.htm
Cedars-Sinai Medical Center. "New blood test could help millions with gastrointestinal disorders." ScienceDaily. www.sciencedaily.com/releases/2013/10/131016095939.htm (accessed January 31, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, January 31, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

CDC: Get Vaccinated for Measles

CDC: Get Vaccinated for Measles

Reuters - US Online Video (Jan. 30, 2015) The CDC is urging people to get vaccinated for measles amid an outbreak that began at Disneyland and has now infected more than 90 people. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Obama To Outline New Plan For Personalized Medicine

Obama To Outline New Plan For Personalized Medicine

Newsy (Jan. 30, 2015) President Obama is expected to speak with drugmakers Friday about his Precision Medicine Initiative first introduced last week. Video provided by Newsy
Powered by NewsLook.com
NFL Concussions Down; Still on Parents' Minds

NFL Concussions Down; Still on Parents' Minds

AP (Jan. 30, 2015) The NFL announced this week that the number of game concussions dropped by a quarter over last season. Still, the dangers of the sport still weigh on players, and parents&apos; minds. (Jan. 30) Video provided by AP
Powered by NewsLook.com
U.S. Wants to Analyze DNA from 1 Million People

U.S. Wants to Analyze DNA from 1 Million People

Reuters - US Online Video (Jan. 30, 2015) The U.S. has proposed analyzing genetic information from more than 1 million American volunteers to learn how genetic variants affect health and disease. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins