Featured Research

from universities, journals, and other organizations

The benefits of bacteria for gut health

Date:
October 18, 2013
Source:
EMBO - excellence in life sciences
Summary:
Scientists have shown that specific gut bacteria are beneficial for maintaining a healthy intestine in the fruit fly Drosophila and mice and also contribute to the overall health of these organisms. The researchers demonstrated that bacteria in the gut, particularly members of the genus Lactobacillus, promote the growth of host epithelial cells and that this is essential for maintaining homeostasis in the intestinal system.

Scientists from the Emory University School of Medicine in Atlanta, United States have shown that specific gut bacteria are beneficial for maintaining a healthy intestine in the fruit fly Drosophila and mice and also contribute to the overall health of these organisms. The researchers demonstrated that bacteria in the gut, particularly members of the genus Lactobacillus, promote the growth of host epithelial cells and that this is essential for maintaining homeostasis in the intestinal system.

Related Articles


The findings, which are published today in The EMBO Journal, could have implications for the treatment of inflammatory bowel disease as well as allergic, metabolic and infectious disorders.

"It is well-known that mammals live in a homeostatic symbiosis with their gut microbiota and that they influence a wide range of physiological processes. However, the molecular mechanisms of the symbiotic cross-talk in the gut are largely unrecognized," stated Andrew S. Neish, Professor at the Emory University School of Medicine, who led the research. "In our study, we have discovered that Lactobacilli can stimulate reactive oxygen species that have regulatory effects on intestinal stem cells, including the activation of proliferation of these cells."

Using two different animal models, the researchers showed that the highly conserved underlying mechanism of this symbiotic relationship is the production of reactive oxygen species (ROS), by a class of conserved enzymes called NADPH oxidases or Nox'es. When animal guts were colonized by Lactobacillus, ROS production caused cell growth in intestinal stem cells. In contrast, in germ-free animals ROS production was absent and resulted in suppressed growth of epithelial cells. Lead author Rheinallt M. Jones, commented: "Our data support the concept of commensal bacterial-induced generation of ROS as a transducer of bacterial signals into host cell signaling, thus establishing a mechanism for host/bacterial cross-talk."

In addition, the study suggests that specific redox-mediated functions may contribute to the identification of further microbes with probiotic potential. The researchers also suggest that the primordial ancestral response to bacteria may well be the generation of ROS for signaling and microbicidal activities.


Story Source:

The above story is based on materials provided by EMBO - excellence in life sciences. Note: Materials may be edited for content and length.


Journal Reference:

  1. Sabrina Büttner, Lukas Habernig, Filomena Broeskamp, Doris Ruli, F Nora Vögtle, Manolis Vlachos, Francesca Macchi, Victoria Küttner, Didac Carmona-Gutierrez, Tobias Eisenberg, Julia Ring, Maria Markaki, Asli Aras Taskin, Stefan Benke, Christoph Ruckenstuhl, Ralf Braun, Chris Van den Haute, Tine Bammens, Anke van der Perren, Kai-Uwe Fröhlich, Joris Winderickx, Guido Kroemer, Veerle Baekelandt, Nektarios Tavernarakis, Gabor G Kovacs, Jörn Dengjel, Chris Meisinger, Stephan J Sigrist, Frank Madeo. Endonuclease G mediates α-synuclein cytotoxicity during Parkinson’s disease. The EMBO Journal, 2013; DOI: 10.1038/emboj.2013.228

Cite This Page:

EMBO - excellence in life sciences. "The benefits of bacteria for gut health." ScienceDaily. ScienceDaily, 18 October 2013. <www.sciencedaily.com/releases/2013/10/131018132058.htm>.
EMBO - excellence in life sciences. (2013, October 18). The benefits of bacteria for gut health. ScienceDaily. Retrieved December 27, 2014 from www.sciencedaily.com/releases/2013/10/131018132058.htm
EMBO - excellence in life sciences. "The benefits of bacteria for gut health." ScienceDaily. www.sciencedaily.com/releases/2013/10/131018132058.htm (accessed December 27, 2014).

Share This


More From ScienceDaily



More Plants & Animals News

Saturday, December 27, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Nevada Farmer Uses Goats to 'recycle' Christmas Trees

Nevada Farmer Uses Goats to 'recycle' Christmas Trees

Reuters - US Online Video (Dec. 27, 2014) — A Nevada goat farmer partners up with a local fire department to 'recycle' discarded Christmas trees. Mana Rabiee reports. Video provided by Reuters
Powered by NewsLook.com
Breeding Christmas Trees Without Needle Mess

Breeding Christmas Trees Without Needle Mess

AP (Dec. 26, 2014) — The presents are unwrapped. Now it's time for another Yuletide tradition: cleaning up the needles that are falling off your Christmas tree. Scientist hope to make that process a ghost of Christmas past. (Dec. 26) Video provided by AP
Powered by NewsLook.com
Venemous White Cobra Gets New Home

Venemous White Cobra Gets New Home

Reuters - Light News Video Online (Dec. 24, 2014) — A venemous white cobra gets a new home at the San Diego Zoo, following a dramatic capture and months of quarantine. Sharon Reich reports Video provided by Reuters
Powered by NewsLook.com
Christmas Trees And Bugs Are Seemingly Symbiotic

Christmas Trees And Bugs Are Seemingly Symbiotic

Newsy (Dec. 24, 2014) — The National Christmas Tree Association says bugs in trees are a relatively small problem, but recommends giving your tree a good shake anyway. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins