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Intranasal application of oxytocin appears to enhance placebo response

Date:
October 22, 2013
Source:
American Medical Association (AMA)
Summary:
A study has been conducted to test whether oxytocin enhances the placebo response in an experimental placebo analgesia model.

The hormone oxytocin may mediate processes such as empathy, trust, and social learning. These are key elements of the patient-physician relationship, which is an important mediator of placebo responses, according to background information in a Research Letter appearing in the October 23/30 issue of JAMA. Simon Kessner, of the University Medical Center Hamburg-Eppendorf, Hamburg, Germany, and colleagues conducted a study to test whether oxytocin enhances the placebo response in an experimental placebo analgesia model.

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Between January and September 2012, the researchers randomly assigned 80 healthy male volunteers to 40 IU of intranasal oxytocin or saline. The researchers and participants were blinded to study drug identity. After 45 minutes, placebo analgesia was assessed using the following standard technique. Two identical inert ointments were applied to 2 sites on each participant's forearm. The ointments were described as an anesthetic that reduces pain (placebo) and an inert control cream (control). In the 15 minutes following application that the participant expected the anesthetic to take effect, the researchers calibrated the intensity at which a 20-second painful heat stimulus was perceived by each individual to rate as a 60 on a scale ranging from 0 (no pain) to 100 (unbearable pain). During the subsequent test phase, a series of 10 of those calibrated stimuli was applied to each of the 2 sites in randomized order. The primary outcome was the placebo analgesic response, defined as the reduction of perceived pain intensity on the placebo site compared with the control site in the oxytocin and saline groups.

Despite identical stimulation on both sites, the difference in pain ratings at the placebo and pain sites were greater in the oxytocin group than in the saline group due to lower pain ratings at the placebo site.

"To our knowledge, our study provides the first experimental evidence that placebo responses can be pharmacologically enhanced by the application of intranasal oxytocin," the authors write. "Further studies are needed to replicate our findings in larger clinical populations, identify the underlying mechanisms, and explore moderating variables such as sex or aspects of patient-physician communication."


Story Source:

The above story is based on materials provided by American Medical Association (AMA). Note: Materials may be edited for content and length.


Journal Reference:

  1. Simon Kessner; Christian Sprenger, MD; Nathalie Wrobel, MSc; Katja Wiech, PhD; Ulrike Bingel, MD. Effect of Oxytocin on Placebo Analgesia: A Randomized Study. JAMA, October 2013

Cite This Page:

American Medical Association (AMA). "Intranasal application of oxytocin appears to enhance placebo response." ScienceDaily. ScienceDaily, 22 October 2013. <www.sciencedaily.com/releases/2013/10/131022170630.htm>.
American Medical Association (AMA). (2013, October 22). Intranasal application of oxytocin appears to enhance placebo response. ScienceDaily. Retrieved March 4, 2015 from www.sciencedaily.com/releases/2013/10/131022170630.htm
American Medical Association (AMA). "Intranasal application of oxytocin appears to enhance placebo response." ScienceDaily. www.sciencedaily.com/releases/2013/10/131022170630.htm (accessed March 4, 2015).

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