Featured Research

from universities, journals, and other organizations

Computational models to decipher biological problems and boost biotech productivity

Date:
November 4, 2013
Source:
Centre for Genomic Regulation
Summary:
Researchers have designed mathematical models that will allow us to understand basic concepts of metabolic and genetic regulatory systems as well as to optimize the production of drugs and other biotechnological products.

Researchers from the Centre for Genomic Regulation (CRG) and Consejo Superior de Investigaciones Cientνficas (CSIC) have designed mathematical models that will allow us to understand basic concepts of metabolic and genetic regulatory systems as well as to optimize the production of drugs and other biotechnological products. The work, published in the scientific journal PLoS Computational Biology, is part of the EU project BioPreDyn, which aims to develop computational models to analyze multi-scale biological networks.

Systems biology is a relatively new field that attempts to understand complex biological problems. For instance, both temporal and spatial inputs are important in regulating genes, and minute differences in these inputs can be amplified to cause drastic changes in the output a regulatory network can produce. Predicting these systems through computational models based on data is a powerful tool useful for basic research as well as for commercial biotechnology (such as producing nutraceuticals and biopharmaceuticals). Based on such approaches,, the EC-funded project BioPreDyn aims to develop models to predict cellular systems.

In the paper published today in PLOS Computational Biology, groups led by the BioPreDyn project coordinator Johannes Jaeger (at the CRG) and Julio R. Banga (at IIM-CSIC) demonstrate a model that can closely predict post-transcriptional gene regulation. In this case, they studied the development of body segments in the fruit fly. The researchers developed algorithms to use in a "systems biology modeling cycle," in which they repeatedly fit a model to gene expression data obtained from laboratory experiments until a good fit was obtained between the predicted and the measured outcomes. "What is important in our study is that we proved that there was a unique and consistent solution to the fitting problem, something that has never before been achieved for a realistic complex model of gene regulation," stated Dr. Jaeger. "This is a big step towards applying the systems biology cycle routinely, in all kinds of biological contexts. Fly development is basic research, but our methods can also be applied for optimizing biotechnological processes, such as the production of food additives or drugs using microorganisms," added Dr. Jaeger.

The collaborative project BioPreDyn aims to develop and then incorporate a vast range of algorithmic tools, such as the one developed in the Jaeger and Banga labs, into an overarching software suite. Working towards this end, BioPreDyn has eleven partners from eight countries, including three industrial partners (Evolva, InSilico Biotechnology, and the CoSMo Company). The software suite will permit end-users (irrespective of their computational skills) to easily access and use the algorithms for their own specific purposes, such as for improving metabolic conditions in organisms used to produce nutraceutical ingredients.


Story Source:

The above story is based on materials provided by Centre for Genomic Regulation. Note: Materials may be edited for content and length.


Journal Reference:

  1. Kolja Becker, Eva Balsa-Canto, Damjan Cicin-Sain, Astrid Hoermann, Hilde Janssens, Julio R. Banga, Johannes Jaeger. Reverse-Engineering Post-Transcriptional Regulation of Gap Genes in Drosophila melanogaster. PLoS Computational Biology, 2013; 9 (10): e1003281 DOI: 10.1371/journal.pcbi.1003281

Cite This Page:

Centre for Genomic Regulation. "Computational models to decipher biological problems and boost biotech productivity." ScienceDaily. ScienceDaily, 4 November 2013. <www.sciencedaily.com/releases/2013/11/131104092732.htm>.
Centre for Genomic Regulation. (2013, November 4). Computational models to decipher biological problems and boost biotech productivity. ScienceDaily. Retrieved July 23, 2014 from www.sciencedaily.com/releases/2013/11/131104092732.htm
Centre for Genomic Regulation. "Computational models to decipher biological problems and boost biotech productivity." ScienceDaily. www.sciencedaily.com/releases/2013/11/131104092732.htm (accessed July 23, 2014).

Share This




More Computers & Math News

Wednesday, July 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Robot Parking Valet Creates Stress-Free Travel

Robot Parking Valet Creates Stress-Free Travel

AP (July 23, 2014) — 'Ray' the robotic parking valet at Dusseldorf Airport in Germany lets travelers to avoid the hassle of finding a parking spot before heading to the check-in desk. (July 23) Video provided by AP
Powered by NewsLook.com
Six Indicted in StubHub Hacking Scheme

Six Indicted in StubHub Hacking Scheme

AP (July 23, 2014) — Six people were indicted Wednesday in an international ring that took over more than 1,000 StubHub users' accounts and fraudulently bought tickets that were then resold. (July 23) Video provided by AP
Powered by NewsLook.com
The Reviews Are In For The Amazon Fire Phone

The Reviews Are In For The Amazon Fire Phone

Newsy (July 23, 2014) — Amazon's first smartphone, the Fire Phone, is set to ship this week, and so far the reviews have been pretty mixed. Video provided by Newsy
Powered by NewsLook.com
Bigger Apple Phone, Bigger Orders

Bigger Apple Phone, Bigger Orders

Reuters - Business Video Online (July 22, 2014) — Apple is asking suppliers to make 70 to 80 million units of its new larger screen iPhone, a lot more initially than its current model. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins