Featured Research

from universities, journals, and other organizations

Potential drug target to nip cancer in the bud

Date:
November 8, 2013
Source:
Agency for Science, Technology and Research (A*STAR), Singapore
Summary:
Scientists have discovered an enzyme, Wip1 phosphatase, as a potential target to weed out the progression of cancer. Although studies in the past have revealed that this enzyme plays a critical role in regulating the budding of tumors, scientists have for the first time unearthed a mechanism for its mode of action.

Scientists at A*STAR have discovered an enzyme, Wip1 phosphatase, as a potential target to weed out the progression of cancer. Although studies in the past have revealed that this enzyme plays a critical role in regulating the budding of tumors, scientists have for the first time unearthed a mechanism for its mode of action.

The research was conducted by Dr Dmitry Bulavin and his team at A*STAR's Institute of Molecular and Cell Biology (IMCB), with their findings published in the 14 October 2013 issue of the scientific journal, Cancer Cell.

The team discovered that Wip1 phosphatase is a key factor that causes point mutations to sprout in human cancers. These types of mutations stem from errors that are made during DNA replication in the body, causing one base-pair in the DNA sequence to be altered.

These mutations can cause cancers to take root, or to become resilient to treatment. By using drugs to inhibit the action of Wip1 phosphatase, cancer growth can be stunted and tumours can be cured without developing resistance. This is a ground-breaking finding that sheds light on how mutations in cancer can potentially be wiped out with drugs, allowing cancers to be treated and eliminated effectively, preventing relapses of tumour growth.

Dr Dmitry Bulavin said, "Our work on Wip1 phosphatase for over a decade has now revealed several key features of this molecule. Our current findings strongly support the use of an anti-Wip1 drug for cancer treatment in order to reduce a high frequency of mutations in the genome, which is one of the main drivers of tumour relapses."

Prof Hong Wan Jin, Executive Director of IMCB, said, "Dmitry has been the pioneering driver in the mechanistic study of Wip1 phosphatase, and this discovery is monumental in providing novel understanding on the role of Wip1 in cancer at the genomic and systems levels. I am confident that his team at IMCB can further their work in cancer research to offer new approaches for potential drugs against this target."


Story Source:

The above story is based on materials provided by Agency for Science, Technology and Research (A*STAR), Singapore. Note: Materials may be edited for content and length.


Journal Reference:

  1. Doria Filipponi, Julius Muller, Alexander Emelyanov, DmitryV. Bulavin. Wip1 Controls Global Heterochromatin Silencing via ATM/BRCA1-Dependent DNA Methylation. Cancer Cell, 2013; 24 (4): 528 DOI: 10.1016/j.ccr.2013.08.022

Cite This Page:

Agency for Science, Technology and Research (A*STAR), Singapore. "Potential drug target to nip cancer in the bud." ScienceDaily. ScienceDaily, 8 November 2013. <www.sciencedaily.com/releases/2013/11/131108102745.htm>.
Agency for Science, Technology and Research (A*STAR), Singapore. (2013, November 8). Potential drug target to nip cancer in the bud. ScienceDaily. Retrieved August 22, 2014 from www.sciencedaily.com/releases/2013/11/131108102745.htm
Agency for Science, Technology and Research (A*STAR), Singapore. "Potential drug target to nip cancer in the bud." ScienceDaily. www.sciencedaily.com/releases/2013/11/131108102745.htm (accessed August 22, 2014).

Share This




More Health & Medicine News

Friday, August 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Drug Used To Treat 'Ebola's Cousin' Shows Promise

Drug Used To Treat 'Ebola's Cousin' Shows Promise

Newsy (Aug. 21, 2014) An experimental drug used to treat Marburg virus in rhesus monkeys could give new insight into a similar treatment for Ebola. Video provided by Newsy
Powered by NewsLook.com
Cadavers, a Teen, and a Medical School Dream

Cadavers, a Teen, and a Medical School Dream

AP (Aug. 21, 2014) Contains graphic content. He's only 17. But Johntrell Bowles has wanted to be a doctor from a young age, despite the odds against him. He was recently the youngest participant in a cadaver program at the Indiana University NW medical school. (Aug. 21) Video provided by AP
Powered by NewsLook.com
American Ebola Patients Released: What Cured Them?

American Ebola Patients Released: What Cured Them?

Newsy (Aug. 21, 2014) It's unclear whether the American Ebola patients' recoveries can be attributed to an experimental drug or early detection and good medical care. Video provided by Newsy
Powered by NewsLook.com
Lost Brain Cells To Blame For Sleep Problems Among Seniors

Lost Brain Cells To Blame For Sleep Problems Among Seniors

Newsy (Aug. 21, 2014) According to a new study, elderly people might have trouble sleeping because of the loss of a certain group of neurons in the brain. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins