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Therapy using stem cells, bone marrow cells, appears safe for patients with ischemic cardiomyopathy

Date:
November 18, 2013
Source:
The JAMA Network Journals
Summary:
Researchers conducted a study to examine the safety of transendocardial stem cell injection with autologous mesenchymal stem cells and bone marrow mononuclear cells in patients with ischemic cardiomyopathy.
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FULL STORY

Alan W. Heldman, M.D., of the University of Miami Miller School of Medicine, and colleagues conducted a study to examine the safety of transendocardial stem cell injection (TESI) with autologous mesenchymal stem cells and bone marrow mononuclear cells in patients with ischemic cardiomyopathy.

An effective proregenerative treatment for ischemic cardiomyopathy would address a major unmet need for many patients. An unresolved issue is whether mesenchymal stem cells have similar safety and possibly greater efficacy than bone marrow mononuclear cells, according to background information in the article.

The included 65 patients with ischemic cardiomyopathy and compared injection of mesenchymal stem cells (n=19) with placebo (n = 11) and bone marrow mononuclear cells (n = 19) with placebo (n = 10), with 1 year of follow-up. The primary measured outcome was treatment-emergent 30-day serious adverse event rate defined as a composite of death, heart attack, stroke, hospitalization for worsening heart failure, perforation (rupture), tamponade (compression of the heart due to collection of blood or fluid), or sustained ventricular arrhythmias.

No patient had treatment emergent-serious adverse event at day 30. Exploratory analyses of 1-year incidence of serious adverse events was 31.6 percent for mesenchymal stem cells, 31.6 percent for bone marrow cells, and 38.1 percent for placebo. Over 1 year, the Minnesota Living with Heart Failure score (a measure of quality of life) improved with mesenchymal stem cells and with bone marrow cells but not with placebo. The 6-minute walk distance increased with mesenchymal stem cells only.

"These results provide the basis for larger studies to provide definitive assessment of safety and to assess efficacy of this new therapeutic approach," the authors write.


Story Source:

The above post is reprinted from materials provided by The JAMA Network Journals. Note: Materials may be edited for content and length.


Journal Reference:

  1. Alan W. Heldman, Darcy L. DiFede, Joel E. Fishman, Juan P. Zambrano, Barry H. Trachtenberg, Vasileios Karantalis, Muzammil Mushtaq, Adam R. Williams, Viky Y. Suncion, Ian K. McNiece, Eduard Ghersin, Victor Soto, Gustavo Lopera, Roberto Miki, Howard Willens, Robert Hendel, Raul Mitrani, Pradip Pattany, Gary Feigenbaum, Behzad Oskouei, John Byrnes, Maureen H. Lowery, Julio Sierra, Mariesty V. Pujol, Cindy Delgado, Phillip J. Gonzalez, Jose E. Rodriguez, Luiza Lima Bagno, Didier Rouy, Peter Altman, Cheryl Wong Po Foo, Jose da Silva, Erica Anderson, Richard Schwarz, Adam Mendizabal, Joshua M. Hare. Transendocardial Mesenchymal Stem Cells and Mononuclear Bone Marrow Cells for Ischemic Cardiomyopathy. JAMA, 2013; DOI: 10.1001/jama.2013.282909

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The JAMA Network Journals. "Therapy using stem cells, bone marrow cells, appears safe for patients with ischemic cardiomyopathy." ScienceDaily. ScienceDaily, 18 November 2013. <www.sciencedaily.com/releases/2013/11/131118102626.htm>.
The JAMA Network Journals. (2013, November 18). Therapy using stem cells, bone marrow cells, appears safe for patients with ischemic cardiomyopathy. ScienceDaily. Retrieved July 30, 2015 from www.sciencedaily.com/releases/2013/11/131118102626.htm
The JAMA Network Journals. "Therapy using stem cells, bone marrow cells, appears safe for patients with ischemic cardiomyopathy." ScienceDaily. www.sciencedaily.com/releases/2013/11/131118102626.htm (accessed July 30, 2015).

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