Featured Research

from universities, journals, and other organizations

Mutations of immune system found in breast cancers

Date:
November 18, 2013
Source:
University of Illinois at Chicago
Summary:
Mutations in the genes that defend the body against cancer-related viruses and other infections may play a larger role in breast cancer than previously thought, according to a study.

Mutations in the genes that defend the body against cancer-related viruses and other infections may play a larger role in breast cancer than previously thought, according to a study at the University of Illinois at Chicago.

Related Articles


Bernard Friedenson, associate professor of biochemistry and molecular genetics at UIC, looked at the DNA sequences of breast cancers from 21 different women and found mutations in genes involved in immunity in every one of them. The mutations were different in each of the breast cancers he analyzed, but all the mutations would have affected some aspect of pathogen recognition and defense, especially against viruses, Friedenson said.

His results are published in the November issue of Functional & Integrative Genomics.

The finding suggests that mutations affecting the immune system play an important role in the development of breast cancer, contrary to the prevailing notion that mutations in the genes that regulate cell division are primarily responsible. Viruses such as human papilloma virus, which can cause cervical cancer, and Epstein-Barr virus, which can cause certain lymphomas, have also been implicated in breast cancer.

"Almost every human being is infected with one or more of these viruses, but most people never develop symptoms, much less breast cancer," Friedenson said.

Friedenson thinks that cancer-related viruses that are normally harmless can become dangerous if genes involved in immunity are mutated, either through heredity or environmental causes. He identified gene mutations in breast cancer cells that affect their ability to recognize viruses, including some mutations that would be expected to significantly increase the cells' vulnerability to viruses implicated in breast cancer.

"If we know which genes are damaged in a breast cancer patient's immune system, prevention or even therapy can be tailored by giving vaccines or perhaps antiviral drugs to reduce the chances of recurrence," said Friedenson. "Sequencing the genomes of individual breast cancers now costs about $2,000, and the cost continues to fall. This information could help physicians prescribe more targeted and effective treatments."


Story Source:

The above story is based on materials provided by University of Illinois at Chicago. Note: Materials may be edited for content and length.


Journal Reference:

  1. Bernard Friedenson. Mutations in components of antiviral or microbial defense as a basis for breast cancer. Functional & Integrative Genomics, 2013; 13 (4): 411 DOI: 10.1007/s10142-013-0336-1

Cite This Page:

University of Illinois at Chicago. "Mutations of immune system found in breast cancers." ScienceDaily. ScienceDaily, 18 November 2013. <www.sciencedaily.com/releases/2013/11/131118132433.htm>.
University of Illinois at Chicago. (2013, November 18). Mutations of immune system found in breast cancers. ScienceDaily. Retrieved December 21, 2014 from www.sciencedaily.com/releases/2013/11/131118132433.htm
University of Illinois at Chicago. "Mutations of immune system found in breast cancers." ScienceDaily. www.sciencedaily.com/releases/2013/11/131118132433.htm (accessed December 21, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, December 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Best Tips to Curb Holiday Carbs

The Best Tips to Curb Holiday Carbs

Buzz60 (Dec. 19, 2014) It's hard to resist those delicious but fattening carbs we all crave during the winter months, but there are some ways to stay satisfied without consuming the extra calories. Vanessa Freeman (@VanessaFreeTV) has the details. Video provided by Buzz60
Powered by NewsLook.com
Sierra Leone Bikers Spread the Message to Fight Ebola

Sierra Leone Bikers Spread the Message to Fight Ebola

AFP (Dec. 19, 2014) More than 100 motorcyclists hit the road to spread awareness messages about Ebola. Nearly 7,000 people have now died from the virus, almost all of them in west Africa, according to the World Health Organization. Video provided by AFP
Powered by NewsLook.com
Researchers Test Colombian Village With High Alzheimer's Rates

Researchers Test Colombian Village With High Alzheimer's Rates

AFP (Dec. 19, 2014) In Yarumal, a village in N. Colombia, Alzheimer's has ravaged a disproportionately large number of families. A genetic "curse" that may pave the way for research on how to treat the disease that claims a new victim every four seconds. Duration: 02:42 Video provided by AFP
Powered by NewsLook.com
The Best Protein-Filled Foods to Energize You for the New Year

The Best Protein-Filled Foods to Energize You for the New Year

Buzz60 (Dec. 19, 2014) The new year is coming and nothing will energize you more for 2015 than protein-filled foods. Fitness and nutrition expert John Basedow (@JohnBasedow) gives his favorite high protein foods that will help you build muscle, lose fat and have endless energy. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins