Featured Research

from universities, journals, and other organizations

Gene plays major role in suppressing cancer

Date:
November 18, 2013
Source:
University of Adelaide
Summary:
Researchers have found that a specific gene plays an important role in suppressing lymphoma, a type of blood cell cancer.

Adelaide researchers have found that a specific gene plays an important role in suppressing lymphoma, a type of blood cell cancer.

Related Articles


The caspase-2 gene is related to a family of proteins that are essential for the self-destruction of cells in the body, a process known as apoptosis.

Caspase-2 was first discovered almost 20 years ago by Professor Sharad Kumar, Co-Director of the Centre for Cancer Biology within SA Pathology, Affiliate Professor in the University of Adelaide's schools of Medicine and Molecular and Biomedical Science, and Adjunct Professor at the University of South Australia's School of Pharmacy and Medical Sciences.

For the past two decades, Professor Kumar's laboratory has been investigating the processes by which cells commit suicide and the molecular machinery that determine whether a cell lives or dies. Cell death is essential to maintain the correct number of cells in the body and to delete cells that have been damaged and become potentially harmful.

"Cell death and survival are controlled by a large number of genes, and aberrations in these genes are often linked to diseases. For example, an inability for cells to evade apoptosis is a well-known hallmark of cancer," Professor Kumar says.

In new findings published today in the Proceedings of the National Academy of Sciences, Professor Kumar and his team, including University of Adelaide PhD student Joseph Puccini, have found in laboratory studies that caspase-2 could prevent tumour formation.

"It does this by ensuring that cells predisposed to cancer maintain a healthy number of chromosomes," Professor Kumar says. "By some unknown mechanism, caspase-2 appears to prevent cells from losing and gaining copies of the chromosomes, which is a trait frequently observed in tumour cells.

"This research not only provides new information on the development of cancer, it also defines how caspase-2 can potentially work as a tumour suppressor gene. This is an exciting finding and one that we're already investigating further," he says.


Story Source:

The above story is based on materials provided by University of Adelaide. Note: Materials may be edited for content and length.


Journal Reference:

  1. J. Puccini, S. Shalini, A. K. Voss, M. Gatei, C. H. Wilson, D. K. Hiwase, M. F. Lavin, L. Dorstyn, S. Kumar. Loss of caspase-2 augments lymphomagenesis and enhances genomic instability in Atm-deficient mice. Proceedings of the National Academy of Sciences, 2013; DOI: 10.1073/pnas.1311947110

Cite This Page:

University of Adelaide. "Gene plays major role in suppressing cancer." ScienceDaily. ScienceDaily, 18 November 2013. <www.sciencedaily.com/releases/2013/11/131118152945.htm>.
University of Adelaide. (2013, November 18). Gene plays major role in suppressing cancer. ScienceDaily. Retrieved March 30, 2015 from www.sciencedaily.com/releases/2013/11/131118152945.htm
University of Adelaide. "Gene plays major role in suppressing cancer." ScienceDaily. www.sciencedaily.com/releases/2013/11/131118152945.htm (accessed March 30, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, March 30, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

S. Leone in New Anti-Ebola Lockdown

S. Leone in New Anti-Ebola Lockdown

AFP (Mar. 28, 2015) Sierra Leone imposed a three-day nationwide lockdown Friday for the second time in six months in a bid to prevent a resurgence of the deadly Ebola virus. Duration: 01:17 Video provided by AFP
Powered by NewsLook.com
These Popular Antibiotics Can Cause Permanent Nerve Damage

These Popular Antibiotics Can Cause Permanent Nerve Damage

Newsy (Mar. 27, 2015) A popular class of antibiotic can leave patients in severe pain and even result in permanent nerve damage. Video provided by Newsy
Powered by NewsLook.com
WH Plan to Fight Antibiotic-Resistant Germs

WH Plan to Fight Antibiotic-Resistant Germs

AP (Mar. 27, 2015) The White House on Friday announced a five-year plan to fight the threat posed by antibiotic-resistant bacteria amid fears that once-treatable germs could become deadly. (March 27) Video provided by AP
Powered by NewsLook.com
House Ready to Pass Medicare Doc Bill

House Ready to Pass Medicare Doc Bill

AP (Mar. 26, 2015) In rare bipartisan harmony, congressional leaders pushed a $214 billion bill permanently blocking physician Medicare cuts toward House passage Thursday, moving lawmakers closer to resolving a problem that has plagued them for years. (March 26) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins