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Fundamental differences found between human cancers, genetically engineered mouse models

Date:
December 5, 2013
Source:
Landes Bioscience
Summary:
Researchers have taken a closer look at existing mouse models of cancer, specifically comparing them to human cancer samples. These genetically engineered mouse models (which usually either overexpress a cancer-causing gene--or "oncogene"--or carry a deletion for a "tumor suppressor" gene) have been extensively used to understand human cancer biology in studies of drug resistance, early detection, metastasis, and cancer prevention, as well as for the preclinical development of novel targeted therapeutics.

Researchers from the Fred Hutchinson Cancer Research Center in Seattle, WA have taken a closer look at existing mouse models of cancer, specifically comparing them to human cancer samples.

These genetically engineered mouse models (which usually either overexpress a cancer-causing gene -- or "oncogene" -- or carry a deletion for a "tumor suppressor" gene) have been extensively used to understand human cancer biology in studies of drug resistance, early detection, metastasis, and cancer prevention, as well as for the preclinical development of novel targeted therapeutics.

Cancer is a multistep process that involves a complex interplay between genetic and epigenetic alterations. Epigenetic modifications mediate changes in gene expression without altering the DNA sequence. One of those modifications, DNA methylation, was found to be significantly different between mouse models of medulloblastoma and primary medulloblastoma human samples.


Story Source:

The above story is based on materials provided by Landes Bioscience. Note: Materials may be edited for content and length.


Journal Reference:

  1. Scott J Diede, Zizhen Yao, C Chip Keyes, Ashlee E Tyler, Joyoti Dey, Christopher S Hackett, Katrina Elsaesser, Christopher J Kemp, Paul E Neiman, William A Weiss, James M Olson, Stephen J Tapscott. Fundamental differences in promoter CpG island DNA hypermethylation between human cancer and genetically engineered mouse models of cancer. Epigenetics, 2013; 8 (12) DOI: 10.4161/epi.26486

Cite This Page:

Landes Bioscience. "Fundamental differences found between human cancers, genetically engineered mouse models." ScienceDaily. ScienceDaily, 5 December 2013. <www.sciencedaily.com/releases/2013/12/131205142220.htm>.
Landes Bioscience. (2013, December 5). Fundamental differences found between human cancers, genetically engineered mouse models. ScienceDaily. Retrieved July 29, 2014 from www.sciencedaily.com/releases/2013/12/131205142220.htm
Landes Bioscience. "Fundamental differences found between human cancers, genetically engineered mouse models." ScienceDaily. www.sciencedaily.com/releases/2013/12/131205142220.htm (accessed July 29, 2014).

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