Featured Research

from universities, journals, and other organizations

New route for development of anti-diarrhea drugs

Date:
December 10, 2013
Source:
Royal College of Surgeons in Ireland (RCSI)
Summary:
New gastroenterology research has uncovered a new route for the development of anti-diarrhea drugs. The new route directly targets cells and molecular processes that control water movement into the intestine and may help with the development of a new class of anti-diarrhea medication.

New gastroenterology research carried out by the RCSI (Royal College of Surgeons in Ireland) in conjunction with Trinity College Dublin and Johns Hopkins University in Baltimore, Maryland has uncovered a new route for the development of anti-diarrhea drugs. The new route directly targets cells and molecular processes that control water movement into the intestine and may help with the development of a new class of anti-diarrhea medication.

The research found that drugs which act on a protein called Farnesoid X Receptor (FXR) in the tissue of the intestine can stop water moving in to the gut. By switching off the water movement in to the gut, this can prevent diarrhea occurring.

Dr Stephen Keely, Associate Director of Molecular Medicine, RCSI and lead researcher, said 'diarrhea diseases are common and debilitating but safe and effective drugs for their treatment are still lacking. Our research has found that FXR is an important regulator of intestinal function and has excellent potential for the development of a new class of anti-diarrhea drugs."

In Ireland, diarrhea is the main reason for approximately 40,000 visits to gastroenterology clinics annually. Epidemics of acute infectious diarrhea are common, and many illnesses such as inflammatory bowel disease, digestive disorders and irritable bowel syndrome cause disruptions to the normal functioning of the intestine and lead to diarrhea. These conditions have a large financial burden to society both in terms of healthcare and lost hours of work.

The research found that drugs which target the FXR protein, target the cells lining the intestine, and because of this they may have broader efficacy and fewer side effects than many anti-diarrheas currently available on the market.

The research was published in Gut, an international journal in gastroenterology.


Story Source:

The above story is based on materials provided by Royal College of Surgeons in Ireland (RCSI). Note: Materials may be edited for content and length.


Journal Reference:

  1. M. S. Mroz, N. Keating, J. B. Ward, R. Sarker, S. Amu, G. Aviello, M. Donowitz, P. G. Fallon, S. J. Keely. Farnesoid X receptor agonists attenuate colonic epithelial secretory function and prevent experimental diarrhoea in vivo. Gut, 2013; DOI: 10.1136/gutjnl-2013-305088

Cite This Page:

Royal College of Surgeons in Ireland (RCSI). "New route for development of anti-diarrhea drugs." ScienceDaily. ScienceDaily, 10 December 2013. <www.sciencedaily.com/releases/2013/12/131210091240.htm>.
Royal College of Surgeons in Ireland (RCSI). (2013, December 10). New route for development of anti-diarrhea drugs. ScienceDaily. Retrieved April 23, 2014 from www.sciencedaily.com/releases/2013/12/131210091240.htm
Royal College of Surgeons in Ireland (RCSI). "New route for development of anti-diarrhea drugs." ScienceDaily. www.sciencedaily.com/releases/2013/12/131210091240.htm (accessed April 23, 2014).

Share This



More Health & Medicine News

Wednesday, April 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Big Pharma Braces for M&A Wave

Big Pharma Braces for M&A Wave

Reuters - Business Video Online (Apr. 22, 2014) Big pharma on the move as Novartis boss, Joe Jimenez, tells Reuters about plans to transform his company via an asset exchange with GSK, and Astra Zeneca shares surge on speculation that Pfizer is looking for a takeover. Joanna Partridge reports. Video provided by Reuters
Powered by NewsLook.com
Study Says Most Crime Not Linked To Mental Illness

Study Says Most Crime Not Linked To Mental Illness

Newsy (Apr. 22, 2014) A new study finds most crimes committed by people with mental illness are not caused by symptoms of their illness or disorder. Video provided by Newsy
Powered by NewsLook.com
Hagel Gets Preview of New High-Tech Projects

Hagel Gets Preview of New High-Tech Projects

AP (Apr. 22, 2014) Defense Secretary Chuck Hagel is given hands-on demonstrations Tuesday of some of the newest research from DARPA _ the military's Defense Advanced Research Projects Agency program. (April 22) Video provided by AP
Powered by NewsLook.com
How Smaller Plates And Cutlery Could Make You Feel Fuller

How Smaller Plates And Cutlery Could Make You Feel Fuller

Newsy (Apr. 22, 2014) NBC's "Today" conducted an experiment to see if changing the size of plates and utensils affects the amount individuals eat. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins