Featured Research

from universities, journals, and other organizations

Researchers have breakthrough on how persistent bacteria avoid antibiotics

Date:
December 29, 2013
Source:
Hebrew University of Jerusalem
Summary:
The mechanism by which some bacteria are able to survive antibacterial treatment has been revealed for the first time. Their work could pave the way for new ways to control such bacteria.

The mechanism by which some bacteria are able to survive antibacterial treatment has been revealed for the first time by Hebrew University of Jerusalem researchers. Their work could pave the way for new ways to control such bacteria.

Related Articles


In addition to the known phenomenon by which some bacteria achieve resistance to antibiotics through mutation, there are other types of bacteria, known as "persistent bacteria," which are not resistant to the antibiotics but simply continue to exist in a dormant or inactive state while exposed to antibacterial treatment. These bacteria later "awaken" when that treatment is over, resuming their detrimental tasks, presenting a dilemma as to how to deal with them. .

Until now, it had been known that there is a connection between these kind of bacteria and the naturally occurring toxin HipA in the bacteria, but scientists did not know the cellular target of this toxin and how its activity triggers dormancy of the bacteria.

Now, the Hebrew University researchers, led by Prof. Gadi Glaser of the Faculty of Medicine and Prof. Nathalie Balaban of the Racah Institute of Physics, have been able to demonstrate how this comes about. Their research showed that when antibiotics attack these bacteria, the HipA toxin disrupts the chemical "messaging" process necessary for nutrients to build proteins. This is interpreted by the bacteria as a "hunger signal" and sends them into an inactive state, (dormancy) in which they are able to survive until the antibacterial treatment is over and they can resume their harmful activity.

The research on persistent bacteria has been conducted in Prof. Balaban's lab for several years, focusing on the development of a biophysical understanding of the phenomenon. It will be combined with other work being done in Prof. Glaser's laboratory focusing on combating persistent bacteria, in the hope of leading to more effective treatment for bacterial infections.


Story Source:

The above story is based on materials provided by Hebrew University of Jerusalem. Note: Materials may be edited for content and length.


Cite This Page:

Hebrew University of Jerusalem. "Researchers have breakthrough on how persistent bacteria avoid antibiotics." ScienceDaily. ScienceDaily, 29 December 2013. <www.sciencedaily.com/releases/2013/12/131229112055.htm>.
Hebrew University of Jerusalem. (2013, December 29). Researchers have breakthrough on how persistent bacteria avoid antibiotics. ScienceDaily. Retrieved December 21, 2014 from www.sciencedaily.com/releases/2013/12/131229112055.htm
Hebrew University of Jerusalem. "Researchers have breakthrough on how persistent bacteria avoid antibiotics." ScienceDaily. www.sciencedaily.com/releases/2013/12/131229112055.htm (accessed December 21, 2014).

Share This


More From ScienceDaily



More Plants & Animals News

Sunday, December 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Researchers Test Colombian Village With High Alzheimer's Rates

Researchers Test Colombian Village With High Alzheimer's Rates

AFP (Dec. 19, 2014) In Yarumal, a village in N. Colombia, Alzheimer's has ravaged a disproportionately large number of families. A genetic "curse" that may pave the way for research on how to treat the disease that claims a new victim every four seconds. Duration: 02:42 Video provided by AFP
Powered by NewsLook.com
Monarch Butterflies Descend Upon Mexican Forest During Annual Migration

Monarch Butterflies Descend Upon Mexican Forest During Annual Migration

Reuters - Light News Video Online (Dec. 19, 2014) Millions of monarch butterflies begin to descend onto Mexico as part of their annual migration south. Rough Cut (no reporter narration) Video provided by Reuters
Powered by NewsLook.com
The Best Protein-Filled Foods to Energize You for the New Year

The Best Protein-Filled Foods to Energize You for the New Year

Buzz60 (Dec. 19, 2014) The new year is coming and nothing will energize you more for 2015 than protein-filled foods. Fitness and nutrition expert John Basedow (@JohnBasedow) gives his favorite high protein foods that will help you build muscle, lose fat and have endless energy. Video provided by Buzz60
Powered by NewsLook.com
Birds Might Be Better Meteorologists Than Us

Birds Might Be Better Meteorologists Than Us

Newsy (Dec. 19, 2014) A new study suggests a certain type of bird was able to sense a tornado outbreak that moved through the U.S. a day before it hit. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins