Scientists have found a genomic deletion that affects fertility and milk yield in dairy cattle at the same time. The discovery can help explain a dilemma in dairy cattle breeding: the negative correlation between fertility and milk production.
For the past many years milk yield in Scandinavian dairy cattle has gone in one clear direction: up. This has been due to targeted breeding programs and modern breeding methods. Despite putting large weight in the breeding goal in Nordic countries, almost no improvement is achieved for fertility. It now seems that this unfavorable correlation between milk yield and fertility is partially affected by a deletion of a simple gene sequence. The presence and effects of this mutation have recently been discovered by scientists from Aarhus University, University of Liθge, MTT Agrifood Research Finland, in collaboration with the Danish Agricultural Advisory Service and the Nordic Cattle Genetic Evaluation.
Scientists, farmers and advisors have generally assumed that the reduction in fertility is primarily due to the negative energy balance of high-producing cows at the peak of their lactation but now the scientists have also found a genetic explanation.
"We have discovered a deletion encompassing four genes as the causative variant and shown that the deletion is a recessive embryonically lethal mutation," explains Goutam Sahana. "This means that the calves die while they are still embryos and are aborted or reported as insemination failure. The fact that the mutation is recessive means that both parents must carry it and pass the genes on to their calf for the calf to be affected. The bulls carrying the deletion can be routinely identified in on-going genomic selection program and by avoiding carrier-by-carrier matings a quantum jump in fertility could be achieved in Nordic red breeds," adds Goutam Sahana.
Can't have your cake and eat it too
To make matters worse, this particular mutation has become rather common in Nordic Red cattle, however, the deletion is totally absent in Nordic Holstein and Danish Jersey populations. Based on the frequency of the mutation in the population, it is estimated that 2.89, 1.32 and 0.42% of embryos are dying in Finnish Ayshire, Swedish Red and Danish Red cattle respectively due to this mutation.
The reason that the deleted gene sequence causing embryo mortality has become relatively widespread is that it has such as strong positive effect on milk yield. By selecting for high milk yields, breeders have inadvertently also selected for embryo mortality -- a situation of so-called hitchhiking.
"Our study demonstrates that embryonic lethal mutations account for a non-negligible fraction of the decline in fertility of domestic cattle and that associated positive effects on milk yield may account for part of the negative genetic correlation. This is at least the seventh example in livestock of an allele that is deleterious in the homozygous state being maintained at high frequency in the populations because of the selective advantage it confers to heterozygotes."
- Naveen Kumar Kadri, Goutam Sahana, Carole Charlier, Terhi Iso-Touru, Bernt Guldbrandtsen, Latifa Karim, Ulrik Sander Nielsen, Frank Panitz, Gert Pedersen Aamand, Nina Schulman, Michel Georges, Johanna Vilkki, Mogens Sandψ Lund, Tom Druet. A 660-Kb Deletion with Antagonistic Effects on Fertility and Milk Production Segregates at High Frequency in Nordic Red Cattle: Additional Evidence for the Common Occurrence of Balancing Selection in Livestock. PLoS Genetics, 2014; 10 (1): e1004049 DOI: 10.1371/journal.pgen.1004049
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