Featured Research

from universities, journals, and other organizations

Diabetes blood glucose targets risk free, research shows

Date:
January 15, 2014
Source:
University of Exeter
Summary:
Diabetes research has underlined the importance of people with diabetes achieving their blood sugar goals, to reduce the risk of complications. The team analyzed people with a specific genetic change, which means they have elevated blood glucose levels from birth. These higher levels mimic guidelines issued to people with both type 1 and type 2 diabetes.

Diabetes research led by the University of Exeter Medical School has underlined the importance of people with diabetes achieving their blood sugar goals, to reduce the risk of complications.

The team analyzed people with a specific genetic change (Glucokinase Maturity Onset Diabetes of the Young, or MODY), which means they have elevated blood glucose levels from birth. These higher levels mimic guidelines issued to people with both type 1 and type 2 diabetes.

International guidelines have proposed that patients with diabetes should keep their HbA1c (a measure of long term glucose control) below 7.5% but there has been a void of evidence on the long-term health impacts of maintaining these blood glucose levels, which are higher than in people without diabetes. But the research team found the study participants' who had higher levels of blood glucose for nearly 50 years had the same risk of diabetes complications as their normal relatives. The research, published in the Journal of the American Medical Association, was based at the National Institute for Health Research (NIHR) Exeter Clinical Research Facility at the Royal Devon and Exeter NHS Foundation Trust, and was funded by Diabetes UK and the NIHR Personal Award Programme.

Professor Andrew Hattersley, of the University of Exeter Medical School, who led the study, said: "This research is relevant to the 200 million worldwide who have diabetes, and who can now be assured that maintaining the recommended blood glucose levels will not lead to complications in the longer term. It is reassuring to know that having a slightly raised blood sugar even for 50 years is safe."

The study team examined the eyes, kidneys, heart and feet of 99 participants with Glucokinase MODY, to establish whether they had complications commonly linked to diabetes, and previously associated with high blood sugar levels. They found no significant difference in the levels of complication when compared to a control group who did not have the genetic change.

Among the participants was Sue Parkes, 66, who has had a raised glucose level all her life due to a change in the glucokinase gene. Full tests of her eyes, kidneys, heart and feet showed no ill effects of this. "It was a relief to know that having a high sugar for 66 years has not given me any of the health problems that can occur in diabetes."

Dr Alasdair Rankin, Diabetes UK Director of Research, said: "We are pleased to have funded this study, which provides reassurance for people with Glucokinase MODY that the moderately raised blood glucose levels they experience from birth appear not to cause an increase in the many potentially devastating long term complications of diabetes. People with other types of diabetes tend to have higher and more variable blood glucose levels than people with MODY and for many achieving the recommended blood glucose levels is extremely difficult. This study provides encouragement for people with Type 2 diabetes that achieving current blood glucose targets will reduce complications, but it's also vital to keep to your recommended targets for blood pressure and cholesterol."


Story Source:

The above story is based on materials provided by University of Exeter. Note: Materials may be edited for content and length.


Journal Reference:

  1. Anna M. Steele, Beverley M. Shields, Kirsty J. Wensley, Kevin Colclough, Sian Ellard, Andrew T. Hattersley. Prevalence of Vascular Complications Among Patients With Glucokinase Mutations and Prolonged, Mild Hyperglycemia. JAMA, 2014; 311 (3): 279 DOI: 10.1001/jama.2013.283980

Cite This Page:

University of Exeter. "Diabetes blood glucose targets risk free, research shows." ScienceDaily. ScienceDaily, 15 January 2014. <www.sciencedaily.com/releases/2014/01/140115113247.htm>.
University of Exeter. (2014, January 15). Diabetes blood glucose targets risk free, research shows. ScienceDaily. Retrieved April 24, 2014 from www.sciencedaily.com/releases/2014/01/140115113247.htm
University of Exeter. "Diabetes blood glucose targets risk free, research shows." ScienceDaily. www.sciencedaily.com/releases/2014/01/140115113247.htm (accessed April 24, 2014).

Share This



More Health & Medicine News

Thursday, April 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Big Pharma Braces for M&A Wave

Big Pharma Braces for M&A Wave

Reuters - Business Video Online (Apr. 22, 2014) Big pharma on the move as Novartis boss, Joe Jimenez, tells Reuters about plans to transform his company via an asset exchange with GSK, and Astra Zeneca shares surge on speculation that Pfizer is looking for a takeover. Joanna Partridge reports. Video provided by Reuters
Powered by NewsLook.com
Study Says Most Crime Not Linked To Mental Illness

Study Says Most Crime Not Linked To Mental Illness

Newsy (Apr. 22, 2014) A new study finds most crimes committed by people with mental illness are not caused by symptoms of their illness or disorder. Video provided by Newsy
Powered by NewsLook.com
Hagel Gets Preview of New High-Tech Projects

Hagel Gets Preview of New High-Tech Projects

AP (Apr. 22, 2014) Defense Secretary Chuck Hagel is given hands-on demonstrations Tuesday of some of the newest research from DARPA _ the military's Defense Advanced Research Projects Agency program. (April 22) Video provided by AP
Powered by NewsLook.com
How Smaller Plates And Cutlery Could Make You Feel Fuller

How Smaller Plates And Cutlery Could Make You Feel Fuller

Newsy (Apr. 22, 2014) NBC's "Today" conducted an experiment to see if changing the size of plates and utensils affects the amount individuals eat. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins