Featured Research

from universities, journals, and other organizations

Novel compound keeps Parkinson's symptoms at bay in mice

Date:
February 12, 2014
Source:
American Chemical Society
Summary:
Scientists report that they have developed a novel compound that appears to protect mice against developing movement problems associated with Parkinson's disease (PD). The research could one day in the future translate into a therapy that could halt the progression of PD.

Protecting specific brain neurons from damage could be one way to treat or prevent Parkinson’s.
Credit: National Institutes of Health

Scientists report that they have developed a novel compound that appears to protect mice against developing movement problems associated with Parkinson's disease (PD). The research, which could one day in the future translate into a therapy that could halt the progression of PD and thereby prevent the symptoms of the disease, appears in ACS' Journal of Medicinal Chemistry.

Related Articles


Onyou Hwang, Ki Duk Park and colleagues explain that PD, which affects an estimated 4 million to 10 million people worldwide, is a progressive movement disorder with no known cure. It often starts with slight tremors and gets worse over time. Muscles go stiff. Walking becomes difficult. Speech is slurred. No one knows for certain what causes the disease, but research has shown that it's linked with the loss of nerve cells in the brain that secrete dopamine, a chemical that is involved in movement and emotion. To find a potential new therapy for PD, the research team searched for a way to shield these brain cells.

They made 56 compounds and tested them to see which ones boosted the production of proteins that protect dopamine-releasing neurons from damage. Of those, one, which they call "12g," proved to be the most active. Interestingly, it protected mice from developing PD-like symptoms in one laboratory test. "Taken together, 12g was found to effectively prevent the motor deficits that are associated with PD," they say.

The authors acknowledge funding from the Korea Institute of Science and Technology, the Korea Health Technology R&D Project, the Ministry of Health and Welfare, the Korea Research Council of Fundamental Science and Technology and the National Research Foundation of Korea.


Story Source:

The above story is based on materials provided by American Chemical Society. Note: Materials may be edited for content and length.


Journal Reference:

  1. Seo Yeon Woo, Ji Hyun Kim, Mi Kyeong Moon, Se-Hee Han, Seul Ki Yeon, Ji Won Choi, Bo Ko Jang, Hyo Jung Song, Yong Gu Kang, Jin Woo Kim, Jaeick Lee, Dong Jin Kim, Onyou Hwang, Ki Duk Park. Discovery of Vinyl Sulfones as a Novel Class of Neuroprotective Agents toward Parkinson’s Disease Therapy. Journal of Medicinal Chemistry, 2014; 140205130908003 DOI: 10.1021/jm401788m

Cite This Page:

American Chemical Society. "Novel compound keeps Parkinson's symptoms at bay in mice." ScienceDaily. ScienceDaily, 12 February 2014. <www.sciencedaily.com/releases/2014/02/140212112837.htm>.
American Chemical Society. (2014, February 12). Novel compound keeps Parkinson's symptoms at bay in mice. ScienceDaily. Retrieved March 30, 2015 from www.sciencedaily.com/releases/2014/02/140212112837.htm
American Chemical Society. "Novel compound keeps Parkinson's symptoms at bay in mice." ScienceDaily. www.sciencedaily.com/releases/2014/02/140212112837.htm (accessed March 30, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, March 30, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Soda, Salt and Sugar: The Next Generation of Taxes

Soda, Salt and Sugar: The Next Generation of Taxes

Washington Post (Mar. 30, 2015) — Denisa Livingston, a health advocate for the Dinι Community Advocacy Alliance, and the Post&apos;s Abby Phillip discuss efforts around the country to make unhealthy food choices hurt your wallet as much as your waistline. Video provided by Washington Post
Powered by NewsLook.com
UnitedHealth Buys Catamaran

UnitedHealth Buys Catamaran

Reuters - Business Video Online (Mar. 30, 2015) — The $12.8 billion merger will combine the U.S.&apos; third and fourth largest pharmacy benefit managers. Analysts say smaller PBMs could also merge. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
S. Leone in New Anti-Ebola Lockdown

S. Leone in New Anti-Ebola Lockdown

AFP (Mar. 28, 2015) — Sierra Leone imposed a three-day nationwide lockdown Friday for the second time in six months in a bid to prevent a resurgence of the deadly Ebola virus. Duration: 01:17 Video provided by AFP
Powered by NewsLook.com
These Popular Antibiotics Can Cause Permanent Nerve Damage

These Popular Antibiotics Can Cause Permanent Nerve Damage

Newsy (Mar. 27, 2015) — A popular class of antibiotic can leave patients in severe pain and even result in permanent nerve damage. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins