Scientists report that they have developed a novel compound that appears to protect mice against developing movement problems associated with Parkinson's disease (PD). The research, which could one day in the future translate into a therapy that could halt the progression of PD and thereby prevent the symptoms of the disease, appears in ACS' Journal of Medicinal Chemistry.
Onyou Hwang, Ki Duk Park and colleagues explain that PD, which affects an estimated 4 million to 10 million people worldwide, is a progressive movement disorder with no known cure. It often starts with slight tremors and gets worse over time. Muscles go stiff. Walking becomes difficult. Speech is slurred. No one knows for certain what causes the disease, but research has shown that it's linked with the loss of nerve cells in the brain that secrete dopamine, a chemical that is involved in movement and emotion. To find a potential new therapy for PD, the research team searched for a way to shield these brain cells.
They made 56 compounds and tested them to see which ones boosted the production of proteins that protect dopamine-releasing neurons from damage. Of those, one, which they call "12g," proved to be the most active. Interestingly, it protected mice from developing PD-like symptoms in one laboratory test. "Taken together, 12g was found to effectively prevent the motor deficits that are associated with PD," they say.
The authors acknowledge funding from the Korea Institute of Science and Technology, the Korea Health Technology R&D Project, the Ministry of Health and Welfare, the Korea Research Council of Fundamental Science and Technology and the National Research Foundation of Korea.
- Seo Yeon Woo, Ji Hyun Kim, Mi Kyeong Moon, Se-Hee Han, Seul Ki Yeon, Ji Won Choi, Bo Ko Jang, Hyo Jung Song, Yong Gu Kang, Jin Woo Kim, Jaeick Lee, Dong Jin Kim, Onyou Hwang, Ki Duk Park. Discovery of Vinyl Sulfones as a Novel Class of Neuroprotective Agents toward Parkinson’s Disease Therapy. Journal of Medicinal Chemistry, 2014; 140205130908003 DOI: 10.1021/jm401788m
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