Featured Research

from universities, journals, and other organizations

Infected Tasmanian devils reveal how cancer cells evolve in response to humans

Date:
February 18, 2014
Source:
Wiley
Summary:
Tasmanian Devil Facial Tumor Disease (DFTD) has ravaged the world's largest carnivorous marsupial since it emerged in 1996, resulting in a population decline of over 90%. Conservation work to defeat the disease has including removing infected individuals from the population and new research explains how this gives us a unique opportunity to understand how human selection alters the evolution of cancerous cells. DFTD is an asexually reproducing clonal cell line, which during the last 16 years has been exposed to negative effects as infected devils, approximately 33% of the population, have been removed from one site, the Forestier Peninsula, in Tasmania between 2006 and 2010.

Tasmanian Devil Facial Tumor Disease (DFTD) has ravaged the world's largest carnivorous marsupial since it emerged in 1996, resulting in a population decline of over 90%. Conservation work to defeat the disease has including removing infected individuals from the population and new research in Evolutionary Applications explains how this gives us a unique opportunity to understand how human selection alters the evolution of cancerous cells.

DFTD is an asexually reproducing clonal cell line, which during the last 16 years has been exposed to negative effects as infected devils, approximately 33% of the population, have been removed from one site, the Forestier Peninsula, in Tasmania between 2006 and 2010.

However, this parasitical disease has been able survive and counteract the effect of deleterious mutation, genomic instability as well as being able to infect more than 100,000 devils.

"In this study, we focus on the evolutionary response of DFTD to a disease suppression trial," said Beata Ujvari, from the, The University of Sydney. "Tumors collected from devils subjected to the removal programme showed accelerated temporal evolution of tetraploidy compared with tumors from other populations where no increase of tetraploid tumors were observed."

The disease eradication trial provides a unique opportunity to discover the long-term effects of human selection on DFTD evolution and to explore this, the team collected tumour tissue samples between 2006 and 2011 at 11 sites within the DFTD affected areas of Tasmania.

"Our study clearly demonstrates that DFTD tumors are able to rapidly respond to increased selection and adapt to a selective regime," said Ujvari. "The results suggest that ploidization may offer yet another pathway to which DFTD is able to adapt to the ever-changing evolutionary landscape sculptured by the devils' immune system. Our study is the first to show that anthropogenic selection may enhance cancer evolution in the wild, and it therefore cautions about what measures we employ to try to halt the spread of this devastating disease."


Story Source:

The above story is based on materials provided by Wiley. Note: Materials may be edited for content and length.


Journal Reference:

  1. Beata Ujvari, Anne-Maree Pearse, Kate Swift, Pamela Hodson, Bobby Hua, Stephen Pyecroft, Robyn Taylor, Rodrigo Hamede, Menna Jones, Katherine Belov, Thomas Madsen. Anthropogenic selection enhances cancer evolution in Tasmanian devil tumours. Evolutionary Applications, 2014; 7 (2): 260 DOI: 10.1111/eva.12117

Cite This Page:

Wiley. "Infected Tasmanian devils reveal how cancer cells evolve in response to humans." ScienceDaily. ScienceDaily, 18 February 2014. <www.sciencedaily.com/releases/2014/02/140218100709.htm>.
Wiley. (2014, February 18). Infected Tasmanian devils reveal how cancer cells evolve in response to humans. ScienceDaily. Retrieved September 17, 2014 from www.sciencedaily.com/releases/2014/02/140218100709.htm
Wiley. "Infected Tasmanian devils reveal how cancer cells evolve in response to humans." ScienceDaily. www.sciencedaily.com/releases/2014/02/140218100709.htm (accessed September 17, 2014).

Share This



More Plants & Animals News

Wednesday, September 17, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Some Tobacco Farmers Thrive Amid Challenges

Some Tobacco Farmers Thrive Amid Challenges

AP (Sep. 16, 2014) The South's tobacco country is surviving, and even thriving in some cases, as demand overseas keeps growers in the fields of one of America's oldest cash crops. (Sept. 16) Video provided by AP
Powered by NewsLook.com
Scientists Given Rare Glimpse of 350-Kilo Colossal Squid

Scientists Given Rare Glimpse of 350-Kilo Colossal Squid

AFP (Sep. 16, 2014) Scientists say a female colossal squid weighing an estimated 350 kilograms (770 lbs) and thought to be only the second intact specimen ever found was carrying eggs when discovered in the Antarctic. Duration: 00:47 Video provided by AFP
Powered by NewsLook.com
Raw: Scientists Examine Colossal Squid

Raw: Scientists Examine Colossal Squid

AP (Sep. 16, 2014) Squid experts in New Zealand thawed and examined an unusual catch on Tuesday: a colossal squid. It was captured in Antarctica's remote Ross Sea in December last year and has been frozen for eight months. (Sept. 16) Video provided by AP
Powered by NewsLook.com
Ivorians Abandon Monkey Pets in Fear Over Ebola Virus

Ivorians Abandon Monkey Pets in Fear Over Ebola Virus

AFP (Sep. 16, 2014) Since the arrival of Ebola in Ivory Coast, Ivorians have been abandoning their pets, particularly monkeys, in the fear that they may transmit the virus. Duration: 00:47 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

    Technology News



    Save/Print:
    Share:

    Free Subscriptions


    Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

    Get Social & Mobile


    Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

    Have Feedback?


    Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
    Mobile: iPhone Android Web
    Follow: Facebook Twitter Google+
    Subscribe: RSS Feeds Email Newsletters
    Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins