Featured Research

from universities, journals, and other organizations

Could metabolism play a role in epilepsy?

Date:
February 19, 2014
Source:
Journal of Visualized Experiments (JOVE)
Summary:
Researchers are exploring a possible link between metabolic defects and seizures. They determined that diet could influence susceptibility to seizures, and they have identified a common diabetes drug that could be useful in treating disorders such as epilepsy. This connection was made in the lab by measuring fruit fly movement with inexpensive web-cams. While there is no known trigger behind seizures in people with epilepsy, the researchers are using their drug-screening technique to investigate potential metabolic causes—using genetically modified, seizure-prone flies.

Researchers from the Franciscan University of Steubenville, Ohio are exploring a possible link between metabolic defects and seizures. They determined that diet could influence susceptibility to seizures, and they have identified a common diabetes drug that could be useful in treating disorders such as epilepsy.

Dr. Daniel Kuebler, the principal investigator behind the experiment, and his lab made the connection by measuring fruit fly movement with inexpensive web-cams. They have published a peer-reviewed, video demonstration of their method in JoVE, The Journal of Visualized Experiments, to assist others in reproducing and further applying the method.

"This technique has allowed us to identify a number of metabolism-altering drugs that affect seizure susceptibility," said Dr. Kuebler, "It has opened up a new line of research looking at the effect dietary modifications have on seizure susceptibility." As published in the article, his lab team determined that metformin, a drug commonly used to treat type II diabetes, reduces the intensity of seizures.

The drug-screening model system is especially ideal for labs on a tight budget, said Dr. Kuebler. According to the article, "Video tracking systems have been used widely to analyze Drosophila melanogaster movement and detect various abnormalities in locomotive behavior. [But] while these systems can provide a wealth of behavioral information, the cost and complexity of these systems can be prohibitive for many labs." Unlike similar experiments, which study the behavior of these flies in aggregate, Dr. Kuebler and his team's approach studies fly behavior one at a time. This is beneficial in that it can determine subtle differences in behavior and seizure alterations, he said.

While there is no known trigger behind seizures in people with epilepsy, Dr. Kuebler and his lab are using their drug-screening technique to investigate potential metabolic causes -- using genetically modified, seizure-prone flies (a family of Drosophila flies called Bang-sensitive paralytic mutants). "It is well known that certain diets, such as the ketogenic diet, have effects on seizures, but there is little agreement on the mechanism behind this diet," said Dr. Kuebler, "This technique allows us to better address this question."

Dr. Kuebler chose to publish his method in a video format because of its capacity to communicate scientific procedures better than text. The video is available at: http://www.jove.com/about/press-releases/83/could-metabolism-play-a-role-in-epilepsy">http://www.jove.com/about/press-releases/83/could-metabolism-play-a-role-in-epilepsy

"The ability to show the seizure behavior visually, [showing] exactly how the recording is done, made the journal a much more attractive option than print only journals," said Dr. Kuebler, "This low cost system is simple enough to set up in an undergraduate teaching lab and can allow for students to do some inquiry based learning labs on a budget."


Story Source:

The above story is based on materials provided by Journal of Visualized Experiments (JOVE). Note: Materials may be edited for content and length.


Cite This Page:

Journal of Visualized Experiments (JOVE). "Could metabolism play a role in epilepsy?." ScienceDaily. ScienceDaily, 19 February 2014. <www.sciencedaily.com/releases/2014/02/140219095321.htm>.
Journal of Visualized Experiments (JOVE). (2014, February 19). Could metabolism play a role in epilepsy?. ScienceDaily. Retrieved September 18, 2014 from www.sciencedaily.com/releases/2014/02/140219095321.htm
Journal of Visualized Experiments (JOVE). "Could metabolism play a role in epilepsy?." ScienceDaily. www.sciencedaily.com/releases/2014/02/140219095321.htm (accessed September 18, 2014).

Share This



More Health & Medicine News

Thursday, September 18, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Cost of Ebola

The Cost of Ebola

Reuters - Business Video Online (Sep. 18, 2014) As Sierra Leone prepares for a three-day "lockdown" in its latest bid to stem the spread of Ebola, Ciara Lee looks at the financial implications of fighting the largest ever outbreak of the disease. Video provided by Reuters
Powered by NewsLook.com
What HealthKit Bug Means For Your iOS Fitness Apps

What HealthKit Bug Means For Your iOS Fitness Apps

Newsy (Sep. 18, 2014) Apple has delayed the launch of the HealthKit app platform, citing a bug. Video provided by Newsy
Powered by NewsLook.com
Residents Vaccinated as Haiti Fights Cholera Epidemic

Residents Vaccinated as Haiti Fights Cholera Epidemic

AFP (Sep. 18, 2014) Haitians receive the second dose of the vaccine against cholera as part of the UN's vaccination campaign. Duration: 00:34 Video provided by AFP
Powered by NewsLook.com
Raw: Elephant Undergoes Surgery in Tbilisi Zoo

Raw: Elephant Undergoes Surgery in Tbilisi Zoo

AP (Sep. 18, 2014) Grand the elephant has successfully undergone surgery to remove a portion of infected tusk at Tbilisi Zoo in Georgia. British veterinary surgeons used an electric drill to extract the infected piece. (Sept. 18) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins