Featured Research

from universities, journals, and other organizations

Lymphoid cells discovered in human spleen, essential for production of antibodies

Date:
February 23, 2014
Source:
IMIM (Hospital del Mar Medical Research Institute)
Summary:
Researchers have discovered the presence of a novel subtype of innate lymphoid cells in human spleen essential for the production of antibodies. This discovery clears the path to the identification of novel strategies to develop more efficient vaccines against encapsulated bacteria, considered highly virulent. This research involved in vitro studies with isolated cells from human spleen samples and in vivo studies performed with different mice models.

Researchers have discovered the presence of a novel subtype of innate lymphoid cells in human spleen essential for the production of antibodies. This discovery, published in the journal Nature Immunology, clears the path to the identification of novel strategies to develop more efficient vaccines against encapsulated bacteria, considered highly virulent.

This work was done by the B cell Biology research group at IMIM (Institut Hospital del Mar d'Investigacions Mediques) in Barcelona, directed by Dr. Andrea Cerutti, ICREA research professor and leader in the field of B lymphocyte biology. Amongst the collaborators of the group are researchers from Icahn School of Medicine of Mount Sinai in New York and Riken Research Center for Integrative Medicine in Japan.

Innate lymphoid cells were recently described by the scientific community and represent the first line of immunological defence on our body surfaces, which are constantly exposed to bacteria, such as the intestine or skin. "For the first time it has been described both their presence and function in human spleen. We have discovered how these cells regulate the innate immune response of a subset of splenic B lymphocytes that are responsible to fight against encapsulated bacteria, causative agents of meningitis or pneumonia," says Dr. Giuliana Magri, member of the research group of B Cell Biology at IMIM and first author in the paper. This new finding improves our understanding on how the immune system protects us against infections.

"The current available vaccines against encapsulated bacteria confer only a limited protection in immunodeficient patients, and are too expensive to be implemented in developing countries. At the same time, we lack information on the underlying mechanisms that regulate B lymphocytes, which has been a major hurdle in the development of novel vaccine strategies. This makes the current discovery key in the design of novel more efficient and well-oriented therapies," concludes Dr. Andrea Cerutti.

This research involved in vitro studies with isolated cells from human spleen samples and in vivo studies performed with different mice models. The work explored the function of the innate lymphoid cells in homeostasis, in short, in the absence of any illness, opening the door in the future to study the possible implication of innate lymphoid cells in diverse pathological processes both at the mucosal and systemic level, as well as deepening our understanding of autoimmune and immunodeficient diseases.


Story Source:

The above story is based on materials provided by IMIM (Hospital del Mar Medical Research Institute). Note: Materials may be edited for content and length.


Journal Reference:

  1. Giuliana Magri, Michio Miyajima, Sabrina Bascones, Arthur Mortha, Irene Puga, Linda Cassis, Carolina M Barra, Laura Comerma, Aleksey Chudnovskiy, Maurizio Gentile, David Llige, Montserrat Cols, Sergi Serrano, Juan Ignacio Arσstegui, Manel Juan, Jordi Yagόe, Miriam Merad, Sidonia Fagarasan, Andrea Cerutti. Innate lymphoid cells integrate stromal and immunological signals to enhance antibody production by splenic marginal zone B cells. Nature Immunology, 2014; DOI: 10.1038/ni.2830

Cite This Page:

IMIM (Hospital del Mar Medical Research Institute). "Lymphoid cells discovered in human spleen, essential for production of antibodies." ScienceDaily. ScienceDaily, 23 February 2014. <www.sciencedaily.com/releases/2014/02/140223131707.htm>.
IMIM (Hospital del Mar Medical Research Institute). (2014, February 23). Lymphoid cells discovered in human spleen, essential for production of antibodies. ScienceDaily. Retrieved September 23, 2014 from www.sciencedaily.com/releases/2014/02/140223131707.htm
IMIM (Hospital del Mar Medical Research Institute). "Lymphoid cells discovered in human spleen, essential for production of antibodies." ScienceDaily. www.sciencedaily.com/releases/2014/02/140223131707.htm (accessed September 23, 2014).

Share This



More Health & Medicine News

Tuesday, September 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Liberia Pleads for Help to Fight Ebola

Liberia Pleads for Help to Fight Ebola

AP (Sep. 22, 2014) — Liberia's finance minister is urging the international community to quickly follow through on pledges of cash to battle Ebola. Bodies are piling up in the capital Monrovia as the nation awaits more help. (Sept. 22) Video provided by AP
Powered by NewsLook.com
Ebola Doctor Says Border Controls Critical

Ebola Doctor Says Border Controls Critical

AP (Sep. 22, 2014) — A Florida doctor who helped fight the expanding Ebola outbreak in West Africa says the disease can be stopped, but only if nations quickly step up their response and make border control a priority. (Sept. 22) Video provided by AP
Powered by NewsLook.com
Global Ebola Aid Increasing But Critics Say It's Late

Global Ebola Aid Increasing But Critics Say It's Late

Newsy (Sep. 21, 2014) — More than 100 tons of medical supplies were sent to West Africa on Saturday, but aid workers say the global response is still sluggish. Video provided by Newsy
Powered by NewsLook.com
Sierra Leone in Lockdown to Control Ebola

Sierra Leone in Lockdown to Control Ebola

AP (Sep. 21, 2014) — Sierra Leone residents remained in lockdown on Saturday as part of a massive effort to confine millions of people to their homes in a bid to stem the biggest Ebola outbreak in history. (Sept. 20) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins