Featured Research

from universities, journals, and other organizations

Unexpected findings: 'Promising' drug failed to improve survival in glioblastoma

Date:
February 28, 2014
Source:
St. Joseph's Hospital and Medical Center
Summary:
A three-year research project on a deadly form of brain cancer has revealed that a 'promising' drug therapy failed to improve survival among patients with newly diagnosed glioblastoma. "Bevacizuman had been shown in earlier studies to be an effective drug in the treatment of patients with recurrent disease. But, on newly diagnosed patients, it did not, in fact, prolong survival," state the authors.

"The results of this study are counter to most expectations," said Dr. Brachman, Director of Radiation Oncology at Barrow and St. Joseph's. "Bevacizuman had been shown in earlier studies to be an effective drug in the treatment of patients with recurrent disease. But, on newly diagnosed patients, it did not, in fact, prolong survival."

The randomized, double-blind placebo controlled trial of 621 adults was funded by the National Cancer Institute and the drug manufacturer Genentech from 2009 to2012. Glioblastoma is the most common primary malignant brain tumor in adults. Few patients survive beyond five years. "This is a deadly disease and there have been very few new therapy choices for patients in the last 20 years. That is why we were so hopeful about this trial," said Dr. Brachman.

Dr. Brachman says that the results of the trial will be disappointing to many patients desperate for a new therapy. "Because this was a unique trial and since it was a very large study done in a double blind, placebo controlled manner, it is quite definite."

Bevacizuman, which is currently an extremely expensive drug, has been shown to be effective in other diseases, including ovarian cancer. The study titled "A Randomized Trial of Bevacizumab for Newly Diagnosed Glioblastoma" was published online February 20 in the New England Journal of Medicine.


Story Source:

The above story is based on materials provided by St. Joseph's Hospital and Medical Center. Note: Materials may be edited for content and length.


Journal Reference:

  1. Mark R. Gilbert, James J. Dignam, Terri S. Armstrong, Jeffrey S. Wefel, Deborah T. Blumenthal, Michael A. Vogelbaum, Howard Colman, Arnab Chakravarti, Stephanie Pugh, Minhee Won, Robert Jeraj, Paul D. Brown, Kurt A. Jaeckle, David Schiff, Volker W. Stieber, David G. Brachman, Maria Werner-Wasik, Ivo W. Tremont-Lukats, Erik P. Sulman, Kenneth D. Aldape, Walter J. Curran, Minesh P. Mehta. A Randomized Trial of Bevacizumab for Newly Diagnosed Glioblastoma. New England Journal of Medicine, 2014; 370 (8): 699 DOI: 10.1056/NEJMoa1308573

Cite This Page:

St. Joseph's Hospital and Medical Center. "Unexpected findings: 'Promising' drug failed to improve survival in glioblastoma." ScienceDaily. ScienceDaily, 28 February 2014. <www.sciencedaily.com/releases/2014/02/140228121437.htm>.
St. Joseph's Hospital and Medical Center. (2014, February 28). Unexpected findings: 'Promising' drug failed to improve survival in glioblastoma. ScienceDaily. Retrieved September 22, 2014 from www.sciencedaily.com/releases/2014/02/140228121437.htm
St. Joseph's Hospital and Medical Center. "Unexpected findings: 'Promising' drug failed to improve survival in glioblastoma." ScienceDaily. www.sciencedaily.com/releases/2014/02/140228121437.htm (accessed September 22, 2014).

Share This



More Health & Medicine News

Monday, September 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Sierra Leone in Lockdown to Control Ebola

Sierra Leone in Lockdown to Control Ebola

AP (Sep. 21, 2014) Sierra Leone residents remained in lockdown on Saturday as part of a massive effort to confine millions of people to their homes in a bid to stem the biggest Ebola outbreak in history. (Sept. 20) Video provided by AP
Powered by NewsLook.com
Sierra Leone's Nationwide Ebola Curfew Underway

Sierra Leone's Nationwide Ebola Curfew Underway

Newsy (Sep. 20, 2014) Sierra Leone is locked down as aid workers and volunteers look for new cases of Ebola. Video provided by Newsy
Powered by NewsLook.com
Changes Found In Brain After One Dose Of Antidepressants

Changes Found In Brain After One Dose Of Antidepressants

Newsy (Sep. 19, 2014) A study suggest antidepressants can kick in much sooner than previously thought. Video provided by Newsy
Powered by NewsLook.com
Could Grief Affect The Immune Systems Of Senior Citizens?

Could Grief Affect The Immune Systems Of Senior Citizens?

Newsy (Sep. 19, 2014) The study found elderly people are much more likely to become susceptible to infection than younger adults going though a similar situation. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins