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Unexpected findings: 'Promising' drug failed to improve survival in glioblastoma

Date:
February 28, 2014
Source:
St. Joseph's Hospital and Medical Center
Summary:
A three-year research project on a deadly form of brain cancer has revealed that a 'promising' drug therapy failed to improve survival among patients with newly diagnosed glioblastoma. "Bevacizuman had been shown in earlier studies to be an effective drug in the treatment of patients with recurrent disease. But, on newly diagnosed patients, it did not, in fact, prolong survival," state the authors.

"The results of this study are counter to most expectations," said Dr. Brachman, Director of Radiation Oncology at Barrow and St. Joseph's. "Bevacizuman had been shown in earlier studies to be an effective drug in the treatment of patients with recurrent disease. But, on newly diagnosed patients, it did not, in fact, prolong survival."

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The randomized, double-blind placebo controlled trial of 621 adults was funded by the National Cancer Institute and the drug manufacturer Genentech from 2009 to2012. Glioblastoma is the most common primary malignant brain tumor in adults. Few patients survive beyond five years. "This is a deadly disease and there have been very few new therapy choices for patients in the last 20 years. That is why we were so hopeful about this trial," said Dr. Brachman.

Dr. Brachman says that the results of the trial will be disappointing to many patients desperate for a new therapy. "Because this was a unique trial and since it was a very large study done in a double blind, placebo controlled manner, it is quite definite."

Bevacizuman, which is currently an extremely expensive drug, has been shown to be effective in other diseases, including ovarian cancer. The study titled "A Randomized Trial of Bevacizumab for Newly Diagnosed Glioblastoma" was published online February 20 in the New England Journal of Medicine.


Story Source:

The above story is based on materials provided by St. Joseph's Hospital and Medical Center. Note: Materials may be edited for content and length.


Journal Reference:

  1. Mark R. Gilbert, James J. Dignam, Terri S. Armstrong, Jeffrey S. Wefel, Deborah T. Blumenthal, Michael A. Vogelbaum, Howard Colman, Arnab Chakravarti, Stephanie Pugh, Minhee Won, Robert Jeraj, Paul D. Brown, Kurt A. Jaeckle, David Schiff, Volker W. Stieber, David G. Brachman, Maria Werner-Wasik, Ivo W. Tremont-Lukats, Erik P. Sulman, Kenneth D. Aldape, Walter J. Curran, Minesh P. Mehta. A Randomized Trial of Bevacizumab for Newly Diagnosed Glioblastoma. New England Journal of Medicine, 2014; 370 (8): 699 DOI: 10.1056/NEJMoa1308573

Cite This Page:

St. Joseph's Hospital and Medical Center. "Unexpected findings: 'Promising' drug failed to improve survival in glioblastoma." ScienceDaily. ScienceDaily, 28 February 2014. <www.sciencedaily.com/releases/2014/02/140228121437.htm>.
St. Joseph's Hospital and Medical Center. (2014, February 28). Unexpected findings: 'Promising' drug failed to improve survival in glioblastoma. ScienceDaily. Retrieved February 27, 2015 from www.sciencedaily.com/releases/2014/02/140228121437.htm
St. Joseph's Hospital and Medical Center. "Unexpected findings: 'Promising' drug failed to improve survival in glioblastoma." ScienceDaily. www.sciencedaily.com/releases/2014/02/140228121437.htm (accessed February 27, 2015).

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