Featured Research

from universities, journals, and other organizations

As one food allergy resolves, another may develop: Same food may trigger both allergies

Date:
March 2, 2014
Source:
Children's Hospital of Philadelphia
Summary:
Some children who outgrow one type of food allergy may then develop another type of allergy, more severe and more persistent, to the same food. The more severe allergy is eosinophilic esophagitis (EoE), which has been increasing in recent years.

Some children who outgrow one type of food allergy may then develop another type of allergy, more severe and more persistent, to the same food. A new study by pediatric allergy experts suggests that health care providers and caregivers carefully monitor children with food allergies to recognize early signs of eosinophilic esophagitis (EoE), a severe and often painful type of allergy that has been increasing in recent years.

"These two types of allergy have some elements in common, but patients with EoE usually don't go on to develop tolerance to the foods that trigger EoE," said pediatric allergist Jonathan M. Spergel, M.D., Ph.D., of The Children's Hospital of Philadelphia (CHOP). Spergel directs CHOP's Center for Pediatric Eosinophilic Disorders, one of the nation's premier programs for these conditions.

Spergel is the senior author of the research, presented today by Solrun Melkorka Maggadottir, M.D., also of CHOP, at the annual meeting of the American Academy of Allergy, Asthma & Immunology (AAAAI) today in San Diego.

Only recently recognized as a distinct condition, EoE involves swelling and inflammation of the esophagus, along with excessive levels of immune cells called eosinophils. Often painful, EoE may cause weight loss, vomiting, heartburn and swallowing difficulties. It can affect any age group, but is often first discovered in children experiencing feeding difficulties and failure to thrive.

The study team compared EoE with IgE-mediated food allergy -- the more familiar type of food allergy that occurs when antibodies mount an exaggerated immune response against proteins in particular foods. Nuts, eggs or milk, for example, may trigger hives, other skin reactions, vomiting or other symptoms.

The researchers performed a retrospective analysis of all children seen at CHOP for EoE between 2000 and 2012, a total of 1,375 patients. Of that number, 425 could be shown to have a definite food causing their condition -- most commonly milk, egg, soy and wheat. Within that subgroup, 17 patients had developed EoE to a food after having outgrown IgE-mediated allergy to that specific food.

"The pattern we found in those 17 patients suggests that the two types of food allergy have distinct pathophysiologies -- they operate by different mechanisms and cause different functional changes," said Spergel. "However, this pattern also raises the possibility that prior IgE-mediated food allergy may predispose a patient to developing EoE to the same food."

Spergel added that approximately 10 percent of patients who undergo desensitization therapy for IgE-mediated foods allergies subsequently develop EoE to the same food -- a fact that health care providers should consider in managing care for patients with food allergies. In desensitization therapy, a clinician exposes a patient to miniscule amount of an allergy-producing food, then gradually increases the amount, aiming for the patient to become tolerant to that food.

Funds from the Joint Center for Gastroenterology and Nutrition of CHOP-HUP and the CHOP Food Allergy Family Research Fund supported this study. Spergel is on both the CHOP staff and the faculty of the Perelman School of Medicine at the University of Pennsylvania. His co-authors are all from either or both institutions.


Story Source:

The above story is based on materials provided by Children's Hospital of Philadelphia. Note: Materials may be edited for content and length.


Cite This Page:

Children's Hospital of Philadelphia. "As one food allergy resolves, another may develop: Same food may trigger both allergies." ScienceDaily. ScienceDaily, 2 March 2014. <www.sciencedaily.com/releases/2014/03/140302143511.htm>.
Children's Hospital of Philadelphia. (2014, March 2). As one food allergy resolves, another may develop: Same food may trigger both allergies. ScienceDaily. Retrieved August 30, 2014 from www.sciencedaily.com/releases/2014/03/140302143511.htm
Children's Hospital of Philadelphia. "As one food allergy resolves, another may develop: Same food may trigger both allergies." ScienceDaily. www.sciencedaily.com/releases/2014/03/140302143511.htm (accessed August 30, 2014).

Share This




More Health & Medicine News

Saturday, August 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

3 Things To Know About The Ebola Outbreak's Progression

3 Things To Know About The Ebola Outbreak's Progression

Newsy (Aug. 29, 2014) Here are three things you need to know about the deadly Ebola outbreak's progression this week. Video provided by Newsy
Powered by NewsLook.com
Killer Amoeba Found in Louisiana Water System

Killer Amoeba Found in Louisiana Water System

AP (Aug. 28, 2014) State health officials say testing has confirmed the presence of a killer amoeba in a water system serving three St. John the Baptist Parish towns. (Aug. 28) Video provided by AP
Powered by NewsLook.com
Who Could Be Burnt by WHO's E-Cigs Move?

Who Could Be Burnt by WHO's E-Cigs Move?

Reuters - Business Video Online (Aug. 28, 2014) The World Health Organisation has called for the regulation of electronic cigarettes as both tobacco and medical products. Ciara Lee looks at the impact of the move on the tobacco industry. Video provided by Reuters
Powered by NewsLook.com
CDC Director On Ebola Outbreak: 'It's Worse Than I Feared'

CDC Director On Ebola Outbreak: 'It's Worse Than I Feared'

Newsy (Aug. 28, 2014) CDC director Tom Frieden says the Ebola outbreak is even worse than he feared. But he also said there's still hope to contain it. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins