Featured Research

from universities, journals, and other organizations

Biological effects of popular artificial sweetener Sucralose

Date:
March 10, 2014
Source:
Taylor & Francis
Summary:
The artificial sweetener sucralose is a biologically active compound, according to an extensive review. Some of the biological effects of sucralose described include: reduction in the number and balance of beneficial bacteria in the gastrointestinal tract, histopathological findings in gastrointestinal tract including lymphocytic infiltrates into epithelium, epithelial scarring, mild depletion of goblet cells and glandular disorganization in the colon, and mutagenic alterations using several types of biological assays. The authors conclude that a careful reassessment of safety is needed regarding the use of sucralose by the general population, particularly special populations such as children, elderly, nursing mothers, persons with diabetes, cancer patients, and persons taking multiple medications.

The artificial sweetener sucralose is a biologically active compound according to an extensive review published by Taylor & Francis in the recent issue of Journal of Toxicology and Environmental Health, Part B: Critical Reviews.

"Sucralose, A Synthetic Organochlorine Sweetener: Overview Of Biological Issues" authored by Susan S. Schiffman, PhD, an internationally known sweetener researcher and Kristina I. Rother, MD, MHSc, of the National Institutes of Health (NIH), summarizes the biological properties of sucralose based on hundreds of archival, peer-reviewed scientific journal publications. Some of the biological effects of sucralose described by Schiffman and Rother include:

  • alterations in insulin, blood glucose, and glucagon-like peptide 1 (GLP-1) levels,
  • metabolism of sucralose in the gastrointestinal tract to metabolites whose identity and safety profile are unknown,
  • induction of cyctochrome P450 and P-glycoprotein in the gastrointestinal tract to levels that may limit the bioavailability of therapeutic drugs,
  • reduction in the number and balance of beneficial bacteria in the gastrointestinal tract,
  • histopathological findings in gastrointestinal tract including lymphocytic infiltrates into epithelium, epithelial scarring, mild depletion of goblet cells and glandular disorganization in the colon,
  • decomposition and generation of chloropropanols (a potentially toxic class of compounds) during baking, and
  • mutagenic alterations using several types of biological assays

Schiffman and Rother present scientific evidence from numerous laboratories that most of these biological effects occur at sucralose dosages approved for use in the food supply by global health authorities. Overall, the scientific data presented in the review indicate that sucralose possesses many characteristics in common with other organochlorine compounds such as organochlorine drugs, pesticides, and industrial chemicals. The authors conclude that a careful reassessment of safety is needed regarding the use of sucralose by the general population, particularly special populations such as children, elderly, nursing mothers, persons with diabetes, cancer patients, and persons taking multiple medications.


Story Source:

The above story is based on materials provided by Taylor & Francis. Note: Materials may be edited for content and length.


Journal Reference:

  1. Susan S. Schiffman, Kristina I. Rother. Sucralose, A Synthetic Organochlorine Sweetener: Overview Of Biological Issues. Journal of Toxicology and Environmental Health, Part B, 2013; 16 (7): 399 DOI: 10.1080/10937404.2013.842523

Cite This Page:

Taylor & Francis. "Biological effects of popular artificial sweetener Sucralose." ScienceDaily. ScienceDaily, 10 March 2014. <www.sciencedaily.com/releases/2014/03/140310111315.htm>.
Taylor & Francis. (2014, March 10). Biological effects of popular artificial sweetener Sucralose. ScienceDaily. Retrieved August 22, 2014 from www.sciencedaily.com/releases/2014/03/140310111315.htm
Taylor & Francis. "Biological effects of popular artificial sweetener Sucralose." ScienceDaily. www.sciencedaily.com/releases/2014/03/140310111315.htm (accessed August 22, 2014).

Share This




More Health & Medicine News

Friday, August 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Drug Used To Treat 'Ebola's Cousin' Shows Promise

Drug Used To Treat 'Ebola's Cousin' Shows Promise

Newsy (Aug. 21, 2014) An experimental drug used to treat Marburg virus in rhesus monkeys could give new insight into a similar treatment for Ebola. Video provided by Newsy
Powered by NewsLook.com
Two US Ebola Patients Leave Hospital Free of the Disease

Two US Ebola Patients Leave Hospital Free of the Disease

AFP (Aug. 21, 2014) Two American missionaries who were sickened with Ebola while working in Liberia and were treated with an experimental drug are doing better and have left the hospital, doctors say on August 21, 2014. Duration: 01:05 Video provided by AFP
Powered by NewsLook.com
Cadavers, a Teen, and a Medical School Dream

Cadavers, a Teen, and a Medical School Dream

AP (Aug. 21, 2014) Contains graphic content. He's only 17. But Johntrell Bowles has wanted to be a doctor from a young age, despite the odds against him. He was recently the youngest participant in a cadaver program at the Indiana University NW medical school. (Aug. 21) Video provided by AP
Powered by NewsLook.com
American Ebola Patients Released: What Cured Them?

American Ebola Patients Released: What Cured Them?

Newsy (Aug. 21, 2014) It's unclear whether the American Ebola patients' recoveries can be attributed to an experimental drug or early detection and good medical care. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins