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Potential New Therapeutic Target for Controlling High Blood Sugar

Date:
March 19, 2014
Source:
UT Southwestern Medical Center
Summary:
A new potential therapeutic target for controlling high blood sugar has been discovered by scientists, a finding that could help the estimated 25 million Americans with type 2 diabetes. Researchers showed that lipid molecules called phosphatidic acids enhance glucose production in the liver. These findings suggest that inhibiting or reducing production of phosphatidic acids may do the opposite.

Dr. Anil Agarwal and Dr. Shireesha Sankella (right) discuss the findings of their recently published study that identified a new potential therapeutic target for controlling high blood sugar.
Credit: Image courtesy of UT Southwestern Medical Center

A UT Southwestern Medical Center study has identified a new potential therapeutic target for controlling high blood sugar, a finding that could help the estimated 25 million Americans with type 2 diabetes.

Researchers showed that lipid molecules called phosphatidic acids enhance glucose production in the liver. These findings suggest that inhibiting or reducing production of phosphatidic acids may do the opposite.

"This study establishes a role for phosphatidic acids in enhancing glucose production by the liver and identifies enzymes involved in the synthesis of phosphatidic acids as potential drug targets," said Dr. Anil Agarwal, Professor of Internal Medicine and senior author of the study in The Journal of Biological Chemistry.

These observations were made while studying a mouse model of lipodystrophy, a rare metabolic disease in which the body is devoid of fat. Lipodystrophy patients often develop diabetes and accumulate fat in the liver because of an imbalance in the body's ability to properly regulate lipids and glucose. The causal gene, AGPAT2, which is involved in the synthesis of phosphatidic acid and triglycerides, was removed in the mice, resulting in rodents with generalized lipodystrophy. The research team then examined what impact this genetic manipulation had on phosphatidic acids and glucose production.

"We expected the levels of phosphatidic acids to go down. However, in examining the livers of these lipodystrophic mice, we unexpectedly found high levels of this lipid class," Dr. Agarwal said, which led to the identification of new targets involved in the production of phosphatidic acids.

The buildup of these lipid molecules was due to an increase in the levels of two enzymes in the liver, diacylglycerol kinase and phospholipase D. Researchers also discovered a marked increase in glucose production in the livers of the lipodystrophic mice.

The lack of normal insulin signaling in these lipodystrophic mice led to unrestricted production of phosphatidic acid, Dr. Agarwal explained, contributing to development of hyperglycemia, or high blood sugar.

Besides revealing a new potential therapy to test for treatment of diabetes, the study's findings may have implications in understanding how cancer develops. Increased phosphatidic acid levels may play an important role in a metabolic pathway that supplies energy to cancer cells.

Lead author Dr. Shireesha Sankella, a postdoctoral researcher in the Division of Nutrition and Metabolic Diseases, now plans to test the inhibitors of diaclyglycerol kinase and phospholipase D in cultured cells and in animals to understand the molecular mechanisms for increased glucose production by phosphatidic acids in liver and cancer cells.


Story Source:

The above story is based on materials provided by UT Southwestern Medical Center. Note: Materials may be edited for content and length.


Journal Reference:

  1. S. Sankella, A. Garg, J. D. Horton, A. K. Agarwal. Hepatic Gluconeogenesis Is Enhanced by Phosphatidic Acid Which Remains Uninhibited by Insulin in Lipodystrophic Agpat2-/- Mice. Journal of Biological Chemistry, 2014; 289 (8): 4762 DOI: 10.1074/jbc.M113.530998

Cite This Page:

UT Southwestern Medical Center. "Potential New Therapeutic Target for Controlling High Blood Sugar." ScienceDaily. ScienceDaily, 19 March 2014. <www.sciencedaily.com/releases/2014/03/140319124528.htm>.
UT Southwestern Medical Center. (2014, March 19). Potential New Therapeutic Target for Controlling High Blood Sugar. ScienceDaily. Retrieved October 20, 2014 from www.sciencedaily.com/releases/2014/03/140319124528.htm
UT Southwestern Medical Center. "Potential New Therapeutic Target for Controlling High Blood Sugar." ScienceDaily. www.sciencedaily.com/releases/2014/03/140319124528.htm (accessed October 20, 2014).

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