Featured Research

from universities, journals, and other organizations

Protein plays key role in infection by oral pathogen

Date:
March 24, 2014
Source:
Forsyth Institute
Summary:
The protein, Transgultaminase 2 is a key component in the process of gum disease, researchers have discovered. Periodontal, or gum, disease is one of the most common infectious diseases. In its more severe forms, such as periodontitis, it causes loss of the bone that supports the teeth. Approximately 65 million adults in the United States are affected by some form of the disease. PG is the major causative agent of periodontitis, and it may also be involved in the development of systemic diseases such as atherosclerosis and rheumatoid arthritis.

Scientists at Forsyth, along with a colleague from Northwestern University, have discovered that the protein, Transgultaminase 2 (TG2), is a key component in the process of gum disease.
Credit: Image courtesy of Forsyth Institute

Scientists at Forsyth, along with a colleague from Northwestern University, have discovered that the protein, Transgultaminase 2 (TG2), is a key component in the process of gum disease. TG2 is widely distributed inside and outside of human cells. The scientists found that blocking some associations of TG2 prevents the bacteria Porphyromonas gingivalis (PG) from adhering to cells. This insight may one day help lead to novel therapies to prevent gum disease caused by PG.

Periodontal, or gum, disease is one of the most common infectious diseases. In its more severe forms, such as periodontitis, it causes loss of the bone that supports the teeth. Approximately 65 million adults in the United States are affected by some form of the disease. PG is the major causative agent of periodontitis, and it may also be involved in the development of systemic diseases such as atherosclerosis and rheumatoid arthritis.

The findings in this study indicate that TG2 is a key mediator in Porphyromonas gingivalis infection. In this research, the scientific team examined the critical role that TG2 plays in enabling Porphyromonas gingivalis to adhere to cells. Using confocal microscopes, clusters of TG2 were found where the bacterium was binding to cells. When the team silenced the expression of TG2, Porphyromonas gingivalis was diminished.

This study, which will be published in Proceedings of the National Academy of Sciences on March 24, 2014, was led by Dr. Heike Boisvert, Assistant Member of the Staff, Department of Microbiology at Forsyth. The work was done in collaboration with Dr. Laszlo Lorand from Northwestern University Feinberg Medical School and Dr. Margaret Duncan, Senior Member of Staff at The Forsyth Institute.

"Once established, Porphyromonas gingivalis is very hard to get rid of" said Boisvert. "The bacterium changes conditions in the surrounding environment to ensure perfect growth; unfortunately, those changes, if untreated, can result in a loss of supportive tissue for our teeth. Also, as has been recently reported, manipulations of host proteins by PG may be involved in the development of systemic diseases such as atherosclerosis and rheumatoid arthritis. The more we know about the relationship of PG with us, the host, the better we can work on how to prevent disease and disease progression. " In the next phase of research, Boisvert will be examining TG2-knockout mice to test their susceptibility to Porphyromonas gingivalis infection and periodontal disease.


Story Source:

The above story is based on materials provided by Forsyth Institute. Note: Materials may be edited for content and length.


Journal Reference:

  1. H. Boisvert, L. Lorand, M. J. Duncan. Transglutaminase 2 is essential for adherence of Porphyromonas gingivalis to host cells. Proceedings of the National Academy of Sciences, 2014; DOI: 10.1073/pnas.1402740111

Cite This Page:

Forsyth Institute. "Protein plays key role in infection by oral pathogen." ScienceDaily. ScienceDaily, 24 March 2014. <www.sciencedaily.com/releases/2014/03/140324154042.htm>.
Forsyth Institute. (2014, March 24). Protein plays key role in infection by oral pathogen. ScienceDaily. Retrieved August 19, 2014 from www.sciencedaily.com/releases/2014/03/140324154042.htm
Forsyth Institute. "Protein plays key role in infection by oral pathogen." ScienceDaily. www.sciencedaily.com/releases/2014/03/140324154042.htm (accessed August 19, 2014).

Share This




More Health & Medicine News

Tuesday, August 19, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola-Hit Sierra Leone's Freetown a City on Edge

Ebola-Hit Sierra Leone's Freetown a City on Edge

AFP (Aug. 19, 2014) Residents of Sierra Leone's capital voice their fears as the Ebola virus sweeps through west Africa. Duration: 00:56 Video provided by AFP
Powered by NewsLook.com
101-Year-Old Working Man Has All The Advice You Need

101-Year-Old Working Man Has All The Advice You Need

Newsy (Aug. 19, 2014) Herman Goldman has worked at the same lighting store for almost 75 years. Find out his secrets to a happy, productive life. Video provided by Newsy
Powered by NewsLook.com
Researcher Testing on-Field Concussion Scanners

Researcher Testing on-Field Concussion Scanners

AP (Aug. 19, 2014) Four Texas high school football programs are trying out an experimental system designed to diagnose concussions on the field. The technology is in response to growing concern over head trauma in America's most watched sport. (Aug. 19) Video provided by AP
Powered by NewsLook.com
American Ebola Patient Apparently Improving, Outbreak Is Not

American Ebola Patient Apparently Improving, Outbreak Is Not

Newsy (Aug. 19, 2014) Nancy Writebol, an American missionary who contracted Ebola, is apparently getting better, according to her husband. The outbreak, however, is not. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins