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Regenerating muscle in Duchenne muscular dystrophy: Age matters

Date:
April 14, 2014
Source:
Sanford-Burnham Medical Research Institute
Summary:
Novel cellular and molecular elements of muscle repair have been revealed by researchers. A new study explains how drugs can induce regeneration, while preventing fibrosis and fat deposition, in dystrophic muscle at early stages of Duchenne muscular dystrophy, an incurable muscle-wasting disease.

HDAC inhibitors (HDACi) promote muscle regeneration in a mouse model of Duchenne Muscular Dystrophy at early stages of disease by targeting fibro-adipogenic progenitors (FAPs). Staining of FAPs from muscles of HDACi-treated young mdx mice reveals presence of differentiated muscle cells (green) at the expense of fat cells (red). Nuclei are stained in blue.
Credit: Lorenzo Puri, M.D.

A team of scientists led by Pier Lorenzo Puri, M.D., associate professor at Sanford-Burnham Medical Research Institute (Sanford-Burnham), in collaboration with Fondazione Santa Lucia in Rome, Italy, have published details of how a class of drugs called "HDACis" drive muscle-cell regeneration in the early stages of dystrophic muscles, but fail to work in late stages. The findings are key to furthering clinical development of HDACis for Duchenne muscular dystrophy (DMD), an incurable muscle-wasting disease.

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A symphony to rebuild muscle

The research, to be published April 15 in Genes and Development, used mouse models of DMD to show how fibro-adipogenic progenitor cells (FAPs) act like orchestra conductors in the music of muscle regeneration. FAPs sit in the space between muscle fibers and coordinate a complex symphony -- receiving the notes that muscle has been damaged and directing muscle stem cells -- satellite cells -- to rebuild muscle.

"HDACis create an environment conducive for FAPs to direct muscle regeneration -- but only during the early stages of DMD progression in mice," said Puri. "At some point, DMD progresses to a pathological point of no return and become permanently resistant to muscle-regeneration cures and to HDACis. HDACis open the blueprints for muscle regeneration

HDACis stands for histone deacetylase inhibitors. They are epigenetic drugs that work by facilitating the accessibility to the genes that code for muscle proteins by the cell machinery that transcribes the genetic code into proteins. In essence, HDACis open the blueprints for protein manufacturing and instruct FAPs to support muscle regeneration.

In normal wear and tear, FAPs direct stem cells within the muscle to regenerate and repair damaged muscle. In DMD, the persistent breakdown of muscle cells creates an environment in such disarray that FAP's ability to direct muscle regeneration is compromised -- like trying to conduct a symphony with punk rock music in the background.

Collaborating to find a treatment for DMD

Puri, along with his Italian colleagues at Fondazione Santa Lucia, Italfarmaco, and Parent Project Muscular Dystrophy, an advocacy association, are currently developing HDACis for the treatment of DMD -- a clinical trial with DMD boys is currently ongoing.

"Our study is important because it provides the rational for the clinical development of HDACis to treat DMD," said Puri. "And, now that we understand the mechanics and sensitivities of the muscle-regeneration system, we have the rationale and can use new tools to select patients most likely to benefit from HDACIs based on their FAP profile, predict outcomes, and see how long patients should remain on the therapy."

"Duchenne muscular dystrophy patients and their families rely on important research such as that performed by Dr. Puri," said Debra Miller, Founder of Cure Duchenne, a patient advocacy group. "Our efforts at Cure Duchenne are to support leading scientists in the world to bring life-saving drugs to help this generation of Duchenne boys, and our vision is to cure Duchenne muscular dystrophy. Every added piece of knowledge about the disease brings us closer to realizing our goals."


Story Source:

The above story is based on materials provided by Sanford-Burnham Medical Research Institute. Note: Materials may be edited for content and length.


Journal Reference:

  1. V. Saccone, S. Consalvi, L. Giordani, C. Mozzetta, I. Barozzi, M. Sandona, T. Ryan, A. Rojas-Munoz, L. Madaro, P. Fasanaro, G. Borsellino, M. De Bardi, G. Frige, A. Termanini, X. Sun, J. Rossant, B. G. Bruneau, M. Mercola, S. Minucci, P. L. Puri. HDAC-regulated myomiRs control BAF60 variant exchange and direct the functional phenotype of fibro-adipogenic progenitors in dystrophic muscles. Genes & Development, 2014; DOI: 10.1101/gad.234468.113

Cite This Page:

Sanford-Burnham Medical Research Institute. "Regenerating muscle in Duchenne muscular dystrophy: Age matters." ScienceDaily. ScienceDaily, 14 April 2014. <www.sciencedaily.com/releases/2014/04/140414091747.htm>.
Sanford-Burnham Medical Research Institute. (2014, April 14). Regenerating muscle in Duchenne muscular dystrophy: Age matters. ScienceDaily. Retrieved October 30, 2014 from www.sciencedaily.com/releases/2014/04/140414091747.htm
Sanford-Burnham Medical Research Institute. "Regenerating muscle in Duchenne muscular dystrophy: Age matters." ScienceDaily. www.sciencedaily.com/releases/2014/04/140414091747.htm (accessed October 30, 2014).

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