Featured Research

from universities, journals, and other organizations

Whooping cough bacterium evolving in Australia, research shows

Date:
April 15, 2014
Source:
University of New South Wales
Summary:
The bacterium that causes whooping cough, Bordetella pertussis, has changed in Australia -- most likely in response to the vaccine used to prevent the disease -- with a possible reduced effectiveness of the vaccine as a result. A team of researchers analyzed strains of Bordetella pertussis from across Australia and found that many strains no longer produce a key surface protein called pertactin.

The bacterium that causes whooping cough, Bordetella pertussis, has changed in Australia -- most likely in response to the vaccine used to prevent the disease -- with a possible reduced effectiveness of the vaccine as a result, a new study shows.
Credit: buffaloboy2513 / Fotolia

The bacterium that causes whooping cough, Bordetella pertussis, has changed in Australia -- most likely in response to the vaccine used to prevent the disease -- with a possible reduced effectiveness of the vaccine as a result, a new study shows.

A UNSW-led team of researchers analyzed strains of Bordetella pertussis from across Australia and found that many strains no longer produce a key surface protein called pertactin.

About 80 per cent of the 2012 whooping cough cases in Australia studied by the team were caused by pertactin-free strains. Pertactin is one of the three proteins, made from purified extracts of Bordetella pertussis bacteria, which are present in the vaccine currently used in Australia. The other two are pertussis toxin and filamentous haemagglutinin.

"It's like a game of hide and seek. It is harder for the antibodies made by the body's immune system in response to vaccination to 'search and destroy' the whooping cough bacteria which lack pertactin," says the senior author of the study, Associate Professor Ruiting Lan, of the UNSW School of Biotechnology and Biomolecular Sciences.

"This could mean that these pertactin-free strains have gained a selective advantage over bacterial strains with the pertactin protein."

The study is published in the journal Emerging Infectious Diseases.

Australia has only recently emerged from an epidemic of whooping cough that went on for an unusually long period -- with about 142,000 cases from 2008 to 2012. Although the number of cases identified was greatly increased by more and better testing, the epidemic was still a major one. Nine babies died of whooping cough during the five years.

The research, led by UNSW PhD student Connie Lam, involved the analysis of 320 bacteria samples from patients with whooping cough obtained during 2008-2012 from five states -- NSW, Victoria, Queensland, South Australia and Western Australia.

The proportion of pertactin-free bacteria rose from five per cent of cases tested in 2008 to 78 per cent in 2012. Pertactin-free strains of pertussis have also been detected overseas, including in countries such as France and the United States.

"The fact that they have arisen independently in different countries suggests this is in response to the vaccine," says Associate Professor Lan.

There is no evidence that the pertactin-free strains are more harmful than other strains, and it is not yet clear whether they reduce the effectiveness of the vaccine in the short or long term.

"More studies are needed to better understand the effects of vaccination on the evolution of the organism," says Associate Professor Lan.

The current acellular vaccine, purified down to three antigens, was introduced in 1997 to replace the previous whole-cell vaccine, after side effects such as fever and crying dissuaded many parents from starting or completing the three doses of vaccine required by six months of age.

"The acellular pertussis vaccine produces antibodies against pertussis toxin which is the main cause of severe disease symptoms produced by the whooping cough bacterium. Vaccination is still the only way to protect against whooping cough, especially for the youngest babies who are most at risk of severe illness," stressed Associate Professor Lan.

Babies need to be immunized at six to eight weeks of age, four months and six months, with a booster at four years.


Story Source:

The above story is based on materials provided by University of New South Wales. Note: Materials may be edited for content and length.


Journal Reference:

  1. Connie Lam, Sophie Octavia, Lawrence Ricafort, Vitali Sintchenko, Gwendolyn L. Gilbert, Nicholas Wood, Peter McIntyre, Helen Marshall, Nicole Guiso, Anthony D. Keil, Andrew Lawrence, Jenny Robson, Geoff Hogg, Ruiting Lan. Rapid Increase in Pertactin-deficientBordetella pertussisIsolates, Australia. Emerging Infectious Diseases, 2014; 20 (4) DOI: 10.3201/eid2004.131478

Cite This Page:

University of New South Wales. "Whooping cough bacterium evolving in Australia, research shows." ScienceDaily. ScienceDaily, 15 April 2014. <www.sciencedaily.com/releases/2014/04/140415094403.htm>.
University of New South Wales. (2014, April 15). Whooping cough bacterium evolving in Australia, research shows. ScienceDaily. Retrieved July 25, 2014 from www.sciencedaily.com/releases/2014/04/140415094403.htm
University of New South Wales. "Whooping cough bacterium evolving in Australia, research shows." ScienceDaily. www.sciencedaily.com/releases/2014/04/140415094403.htm (accessed July 25, 2014).

Share This




More Health & Medicine News

Friday, July 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

New Painkiller Designed To Discourage Abuse: Will It Work?

New Painkiller Designed To Discourage Abuse: Will It Work?

Newsy (July 24, 2014) The FDA approved Targiniq ER on Wednesday, a painkiller designed to keep users from abusing it. Like any new medication, however, it has doubters. Video provided by Newsy
Powered by NewsLook.com
Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Newsy (July 24, 2014) Sheik Umar Khan has treated many of the people infected in the Ebola outbreak, and now he's become one of them. Video provided by Newsy
Powered by NewsLook.com
Condemned Man's US Execution Takes Nearly Two Hours

Condemned Man's US Execution Takes Nearly Two Hours

AFP (July 24, 2014) America's death penalty debate raged Thursday after it took nearly two hours for Arizona to execute a prisoner who lost a Supreme Court battle challenging the experimental lethal drug cocktail. Duration: 00:55 Video provided by AFP
Powered by NewsLook.com
Can Watching TV Make You Feel Like A Failure?

Can Watching TV Make You Feel Like A Failure?

Newsy (July 24, 2014) A study by German researchers claims watching TV while you're stressed out can make you feel guilty and like a failure. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

    Health News

      Environment News

        Technology News



          Save/Print:
          Share:

          Free Subscriptions


          Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

          Get Social & Mobile


          Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

          Have Feedback?


          Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
          Mobile: iPhone Android Web
          Follow: Facebook Twitter Google+
          Subscribe: RSS Feeds Email Newsletters
          Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins