Featured Research

from universities, journals, and other organizations

HIV and schistosomiasis coinfection in African children: More research needed

Date:
April 17, 2014
Source:
Liverpool School of Tropical Medicine
Summary:
More research is needed on HIV and schistosomiasis coinfection in children in sub-Saharan Africa, experts say. They looked at previous research into the joint burden of HIV/AIDS and schistosomiasis of children, and found that while disease-specific control interventions are continuing, potential synergies in the control efforts for the two diseases have not been investigated. The team focused on children with schistosomiasis and assessed the risk of increased HIV transmission and progression and impaired response to drugs when given alongside HIV interventions.

Researchers from LSTM have called for more research to be carried out into HIV and schistosomiasis coinfection in children in sub-Saharan Africa. In a paper in The Lancet Infectious Diseases LSTM's Professor Russell Stothard, working with colleagues in the department of Parasitology and researchers from Cape Western Reserve University, in Cleveland Ohio, University of Cambridge and the Royal Veterinary College looked at previous research into the joint burden of HIV/AIDS and schistosomiasis of children, and found that while disease-specific control interventions are continuing, potential synergies in the control efforts for the two diseases have not been investigated.

The team focused on children with schistosomiasis and assessed the risk of increased HIV transmission and progression and impaired response to drugs when given alongside HIV interventions. The team concluded from their research that there needs to be more work carried out into understanding the interactions of the diseases within children to look at the potential for combined responses.

Schistosomiasis is a chronic inflammatory disease caused by a water-borne parasitic blood fluke, infecting 220 million people in sub-Saharan Africa, with even more people at risk, mainly children. While infection can happen in very early childhood depending on an infant's environmental exposure to parasite-infested water, until recently early exposures have been overlooked with treatment, mass drug administration of praziquantel, given to children of school age.

HIV, like schistosomiasis, is one of the most widespread infections in the world and there is a substantial geographical overlap between the two. Interventions against the disease have focussed on universal access to highly active antiretroviral therapy (HAART), but many children in sub-Saharan Africa for care late in their HIV progression and there are nearly 1000 new cases of paediatric HIV infection every day.

First Author and Project Paediatrician, Dr Amaya Bustinduy, said: "While multidisease approaches are being promoted by WHO, such as those for HIV and Malaria, platforms for research and control of HIV and schistosomiasis do not exist. Both disease pose difficulties in terms of their diagnosis in early childhood, and all studies of coinfection so far have been limited to adults. It is thought that in adults schistosomiasis infection may precede that of HIV, but clearly as HIV infection in infants and young children is nearly always vertically transmitted (from mother to child) HIV infection precedes that of schistosomiasis."

The paper goes on to explore the effect that HIV has on the efficacy of the drugs taken to treat the parasitic infection, explores the lack of data available for the dosage of praziquatal in children and its interaction with HAART as well as the potential effect of HIV on the expanding childhood vaccination program across sub-Saharan Africa. "We hope that this review will underline the real need for further work into the effects of coinfection" added Professor Russell Stothard, Corresponding Author of the paper, "Failure to develop and implement a realistic research agenda for infected children will result in the neglect of the youngest children who might be at particular risk for increased HIV transmission, HIV progression, and impaired response to drugs."


Story Source:

The above story is based on materials provided by Liverpool School of Tropical Medicine. Note: Materials may be edited for content and length.


Journal Reference:

  1. Amaya Bustinduy, Charles King, Janet Scott, Sarah Appleton, José Carlos Sousa-Figueiredo, Martha Betson, J Russell Stothard. HIV and schistosomiasis co-infection in African children. The Lancet Infectious Diseases, 2014; DOI: 10.1016/S1473-3099(14)70001-5

Cite This Page:

Liverpool School of Tropical Medicine. "HIV and schistosomiasis coinfection in African children: More research needed." ScienceDaily. ScienceDaily, 17 April 2014. <www.sciencedaily.com/releases/2014/04/140417090732.htm>.
Liverpool School of Tropical Medicine. (2014, April 17). HIV and schistosomiasis coinfection in African children: More research needed. ScienceDaily. Retrieved August 29, 2014 from www.sciencedaily.com/releases/2014/04/140417090732.htm
Liverpool School of Tropical Medicine. "HIV and schistosomiasis coinfection in African children: More research needed." ScienceDaily. www.sciencedaily.com/releases/2014/04/140417090732.htm (accessed August 29, 2014).

Share This




More Health & Medicine News

Friday, August 29, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

3 Things To Know About The Ebola Outbreak's Progression

3 Things To Know About The Ebola Outbreak's Progression

Newsy (Aug. 29, 2014) — Here are three things you need to know about the deadly Ebola outbreak's progression this week. Video provided by Newsy
Powered by NewsLook.com
Killer Amoeba Found in Louisiana Water System

Killer Amoeba Found in Louisiana Water System

AP (Aug. 28, 2014) — State health officials say testing has confirmed the presence of a killer amoeba in a water system serving three St. John the Baptist Parish towns. (Aug. 28) Video provided by AP
Powered by NewsLook.com
Who Could Be Burnt by WHO's E-Cigs Move?

Who Could Be Burnt by WHO's E-Cigs Move?

Reuters - Business Video Online (Aug. 28, 2014) — The World Health Organisation has called for the regulation of electronic cigarettes as both tobacco and medical products. Ciara Lee looks at the impact of the move on the tobacco industry. Video provided by Reuters
Powered by NewsLook.com
CDC Director On Ebola Outbreak: 'It's Worse Than I Feared'

CDC Director On Ebola Outbreak: 'It's Worse Than I Feared'

Newsy (Aug. 28, 2014) — CDC director Tom Frieden says the Ebola outbreak is even worse than he feared. But he also said there's still hope to contain it. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins