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Mutation found in jaw tumor: World's First

Date:
April 24, 2014
Source:
University of Eastern Finland
Summary:
A gene mutation in ameloblastoma, which is a tumor of the jaw has been discovered by a team of researchers in a world-first finding. Ameloblastoma is an odontogenic tumor with a high tendency to recur after treatment. It is most often found in the posterior of the lower jaw, and are treated by surgery, often resulting in tissue deficiencies in the jaws as well as loss of several teeth. A suitable drug therapy could reduce the need for surgery and the recurrence of ameloblastoma, but finding such a treatment requires a better understanding of the pathogenesis of the tumor.

A Finnish team of researchers was the first in the world to discover a gene mutation in ameloblastoma, which is a tumor of the jaw.

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Ameloblastoma is an odontogenic tumor with a high tendency to recur after treatment. Ameloblastoma is most often found in the posterior of the lower jaw. Ameloblastomas are treated by surgery, often resulting in tissue deficiencies in the jaws as well as loss of several teeth. A suitable drug therapy could reduce the need for surgery and the recurrence of ameloblastoma, but finding such a treatment requires a better understanding of the pathogenesis of the tumor.

Researchers have been searching for the mutation that causes ameloblastoma for decades, and this mutation has now been found in a patient living in the eastern part of Finland. The core of the team making the discovery comprises researchers of the University of Turku and the University of Eastern Finland. According to the leaders of the team, Professor of Medical Biochemistry Klaus Elenius of the University of Turku, and Professor of Oral Diagnostic Sciences Kristiina Heikinheimo of the University of Eastern Finland, the finding is a scientific breakthrough. The significance of the finding is further emphasised by the fact that it has direct implications for treatment, because a targeted drug for the mutation in question already exists.

The findings were published in Journal of Pathology in March.


Story Source:

The above story is based on materials provided by University of Eastern Finland. Note: Materials may be edited for content and length.


Journal Reference:

  1. Kari J Kurppa, Javier Catσn, Peter R Morgan, Ari Ristimδki, Blandine Ruhin, Jari Kellokoski, Klaus Elenius, Kristiina Heikinheimo. High frequency of BRAFV600E mutations in ameloblastoma. The Journal of Pathology, 2014; 232 (5): 492 DOI: 10.1002/path.4317

Cite This Page:

University of Eastern Finland. "Mutation found in jaw tumor: World's First." ScienceDaily. ScienceDaily, 24 April 2014. <www.sciencedaily.com/releases/2014/04/140424102301.htm>.
University of Eastern Finland. (2014, April 24). Mutation found in jaw tumor: World's First. ScienceDaily. Retrieved November 26, 2014 from www.sciencedaily.com/releases/2014/04/140424102301.htm
University of Eastern Finland. "Mutation found in jaw tumor: World's First." ScienceDaily. www.sciencedaily.com/releases/2014/04/140424102301.htm (accessed November 26, 2014).

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