Featured Research

from universities, journals, and other organizations

Killing Kindlin-3 to cure breast cancer: 'Blood' protein implicated

Date:
May 1, 2014
Source:
Federation of American Societies for Experimental Biology
Summary:
A protein believed to be limited to the hematopoietic system, called Kindlin-3, has been identified as a major player in both the formation and spread of breast cancer to other organs. This discovery could open the door to an entirely new class of breast cancer drugs that targets this protein's newly found activity.

A protein believed to be limited to the hematopoietic system, called Kindlin-3, has been identified as a major player in both the formation and spread of breast cancer to other organs. This discovery, published in the May 2014 issue of The FASEB Journal, could open the door to an entirely new class of breast cancer drugs that targets this protein's newly found activity.

"Kill Kindlin-3 to cure cancer," said Elzbieta Pluskota, Ph.D., a researcher involved in the work from the Department of Molecular Cardiology at the Cleveland Clinic Lerner Research Institute in Cleveland, Ohio. "Let our moms, wives, sisters and daughters live long and healthy lives."

To make this discovery, Pluskota and colleagues searched gene expression databases to identify gene products that are elevated in breast cancer, and therefore, likely candidates to be involved in the disease progression. They found that Kindlin-3 expression levels are significantly elevated in breast cancer tumors when compared to the adjacent normal mammary tissue. In fact, Kindlin-3 was in the top 3 percent of gene products elevated in breast cancer cells. Then the scientists studied two groups of animal models. The first group (control group) was implanted with cancer cells that did not express Kindlin-3, while the second group (experimental group) received cancer cells that were engineered to express high levels of Kindlin-3. The experimental group developed bigger tumors that grew significantly faster, metastasized more, and were more angiogenic than the control group. Further biochemical analyses showed that Kindlin-3 enhanced the production and secretion of VEGF, a molecule that is required for the formation of new blood vessels. This study also identified a previously unknown function of Kindlin-3; the regulation of epithelial-mesenchymal transition, a process required for cancer cells to become mobile and invasive.

"Just when scientists thought they knew all there was to know about Kindlin-3, we now learn that this protein has mostly been flying under the radar in breast cancer research all along," said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal. "This discovery puts us on a path toward developing treatments, which slow, stop or reverse the progression of some of the most aggressive breast cancers."


Story Source:

The above story is based on materials provided by Federation of American Societies for Experimental Biology. Note: Materials may be edited for content and length.


Journal Reference:

  1. K. Sossey-Alaoui, E. Pluskota, G. Davuluri, K. Bialkowska, M. Das, D. Szpak, D. J. Lindner, E. Downs-Kelly, C. L. Thompson, E. F. Plow. Kindlin-3 enhances breast cancer progression and metastasis by activating Twist-mediated angiogenesis. The FASEB Journal, 2014; 28 (5): 2260 DOI: 10.1096/fj.13-244004

Cite This Page:

Federation of American Societies for Experimental Biology. "Killing Kindlin-3 to cure breast cancer: 'Blood' protein implicated." ScienceDaily. ScienceDaily, 1 May 2014. <www.sciencedaily.com/releases/2014/05/140501111728.htm>.
Federation of American Societies for Experimental Biology. (2014, May 1). Killing Kindlin-3 to cure breast cancer: 'Blood' protein implicated. ScienceDaily. Retrieved October 2, 2014 from www.sciencedaily.com/releases/2014/05/140501111728.htm
Federation of American Societies for Experimental Biology. "Killing Kindlin-3 to cure breast cancer: 'Blood' protein implicated." ScienceDaily. www.sciencedaily.com/releases/2014/05/140501111728.htm (accessed October 2, 2014).

Share This



More Health & Medicine News

Thursday, October 2, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Pregnancy Spacing Could Have Big Impact On Autism Risks

Pregnancy Spacing Could Have Big Impact On Autism Risks

Newsy (Oct. 1, 2014) A new study says children born less than one year and more than five years after a sibling can have an increased risk for autism. Video provided by Newsy
Powered by NewsLook.com
Robotic Hair Restoration

Robotic Hair Restoration

Ivanhoe (Oct. 1, 2014) A new robotic procedure is changing the way we transplant hair. The ARTAS robot leaves no linear scarring and provides more natural results. Video provided by Ivanhoe
Powered by NewsLook.com
Insertable Cardiac Monitor

Insertable Cardiac Monitor

Ivanhoe (Oct. 1, 2014) A heart monitor the size of a paperclip that can save your life. The “Reveal Linq” allows a doctor to monitor patients with A-Fib on a continuous basis for up to 3 years! Video provided by Ivanhoe
Powered by NewsLook.com
Attacking Superbugs

Attacking Superbugs

Ivanhoe (Oct. 1, 2014) Two weapons hospitals can use to attack superbugs. Scientists in Ireland created a new gel resistant to superbugs, and a robot that can disinfect a room in minutes. Video provided by Ivanhoe
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins